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Abstract

A B S T R A C T
Background. Systemic lupus erythematosus (SLE) is a chronic autoimmune
disease which has a variety of clinical phenotypes with a complex clinical course.
The clinical phenotypes are highly variable which can be characterized by acute
attacks, active periods, controllable or remission. Mean platelet volume (MPV) is a
straightforward accessible indicator of platelet activity and is associated with
systemic inflammation. The routine usage of MPV as markers for disease activity
in SLE remains problematic. Early detection of disease progression is pivotal in the
management of SLE for obtaining better outcomes. Objective. The study aimed to
confirm that the measurement of the disease severity in patients with SLE using
Mex-SLEDAI has a negative correlation with the decrease of MPV value. Methods.
This cross-sectional analytic descriptive study was conducted using secondary data
from the medical records of patients with SLE older than 18 years of age who were
not taking antiplatelets in the Internal Medicine policlinic of Dr. Sardjito General
Hospital in 2018. Patients with a previous history of cardiovascular and
cerebrovascular events, malignancies, receiving a treatment for infections,
including sepsis, chronic infections (i.e. tuberculosis, cytomegalovirus, herpes
simplex, herpes zoster), HIV, hepatitis B or hepatitis C, and incomplete data of
medical record were excluded. The correlation between SLEDAI Mex and MPV
values was evaluated using the Spearman's correlation test. Results. Sixty-seven
subjects (65 women, 2 men) aged 34 ± 11 years were recruited in the study. The
median duration of diagnosis was 38,2 ± 45,7 months. Arthritis, skin rash and
photosensitivity were identified in 81,1%, 53,7%, and 46,3% of patients,
respectively. The Mex-SLEDAI score ranged from 0 to 16. The average of MPV value
is 9.73 ± 1.21 fL. A significant correlation between MPV and SLEDAI Mex was
observed (p = 0.03 (p <0.05), r = -0.255). Conclusion. The more severe SLE disease
activity (based on the Mex-SLEDAI scoring), the more negative correlation with the
MPV value.

Article Details

How to Cite
Paramaiswari, A., Susilo, D. H., & Wachid Achadiono, D. N. (2021). Correlation Between Mex-Sledai and Mean Platelet Volume In Systemic Lupus Erythematosus Patients. Indonesian Journal of Rheumatology, 12(2), 293-301. https://doi.org/10.37275/ijr.v12i2.158