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Abstract

Background: Hemophilia can cause musculoskeletal complications and decreased bone density is one of those complications. The profile of hemophilic patients with decreased bone density in Indonesia is still unknown.

Objective: To estimate the proportion of decreased bone density hemophilia and to learn the characteristics of hemophilic patients with decreased bone density.

Methods: This is a cross-sectional study done in June - November 2012. Subjects were adult hemophilic patients from 19-50 years old in Hematology- Oncology outpatient clinic Cipto Mangunkusumo Hospital. Estimated variables were bone density mass, age, body
mass index, physical activity, arthropathy, substitution therapy, HIV, and HCV infection.

Result: 63 subjects were included in the study with median age of 26 years old. The proportion of decreased bone density in hemophilia was 6.3%. Subjects with decreased bone density were younger (19 years old vs 26 years old), have lower BMI (18,6 + 2,8 kg/m2 vs 21,5 + 3,8 kg/m2), used more substitution therapy (4047 IU/month vs 2000 IU/month), and have better clinical arthropathy score. HCV infection happened on 25% subjects with decreased bone density while HIV was on 1.6% of subjects.

Conclusion: Decreased bone density was found in 6.3% of subjects with hemophilia. They were younger, have lower BMI, better joint score, lower infection caused by transfusion, and more bleeding compared with subjects with normal bone density.

Article Details

How to Cite
Anggoro, S., Setyohadi, B., Sukrisman, L., & Setiati, S. (2018). The characteristics of hemophilic patients with decreased bone density in Cipto Mangunkusumo Hospital Jakarta. Indonesian Journal of Rheumatology, 4(1). https://doi.org/10.37275/ijr.v4i1.88

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