2024-03-29T13:54:34Z
https://journalrheumatology.or.id/index.php/index/oai
oai:ojs.data.journalrheumatology.or.id:article/5
2020-05-07T02:47:35Z
ijr:ORI
Validity and reliability fatigue severity scale in patients with Systemic Lupus Erythematosus (SLE) in Indonesia
Rifa’i, A
Kalim, Handono
Handono, Kusworini
Wahono, Cesarius Singgih
Background: Fatigue is one symptom of Systemic Lupus Erythematosus (SLE), which has an important effect on the quality of life. Fatigue Severity Scale (FSS)is one parameter fatigue symptom in SLE. The purpose of this study was to determine the validity and reliabilitybetween FSS with duration of ilness and disease activity of SLE patients in Indonesia.Methods: FSS performed on 40 patients with SLE. FSS original English version has been converted-translated into Indonesian version by a team of RheumatologyImmunology Medical Faculty of Brawijaya University. Reliability determined by Cronbach’s Alpha values (>0.6). Validity was determined by the value of Corrected Item-Total Correlation which each item was a valid question if below value of Cronbach’s Alpha.Results: The reliability value was determined by Cronbach’s Alpha values (>0.6) in which the SLE patients in this study had a Cronbach’s Alpha value of 0.946. Value of Corrected Item-Total Correlation overall under Cronbach’s Alpha value (range = 0.684-0.859) which indicates that each item was a valid question. There were correlation between the FSS Indonesian version with disease duration (p = 0.000) as well as the value of r = 0.581, with SLEDAI (p = 0.000) with a value of r = 0.833. Conclusion: FSS in Indonesian version has a good reliability and validity and can be used by clinicians andother researchers to assess the condition of fatigue in SLE patients in Indonesia.Keywords: validity, reliability, fatigue, fatigue severity scale, systemic lupus erythematosus
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/5
10.37275/ijr.v8i1.5
Indonesian Journal of Rheumatology; Vol. 8 No. 1 (2016): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v8i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/5/3
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/6
2020-05-07T02:47:35Z
ijr:ORI
Correlation between osteoarthritis grading in femoropatella joint and patella malalignment with pain and disability using WOMAC score
Kiswati, S
Suntoko, Bantar
Sukmaningtyas, H
Background: Osteoarthritis (OA) in femoropatella often causes pain and disabilities in the lower extremities. In 2011 found a significance association between knee pain with osteophytes in femoropatella joints compared with osteophytes in femorotibia joints. Niu J et al. found knee joint with lateral patellar malalignment and lateral patellar tilt had increased prevalence of femoropatella OA, similar study in Caucasian and African Americans patients found an association between patellar malalignment with severe knee pain and diseaseprogressivity. In this study, researchers correlate grading OA genu with pain and disability using WOMAC scores and malalignment correlate with pain and disability with WOMAC scores without assessing the progression of the disease. In this study, using cross-sectional at one time whereas previous studies using multi-center cohort were evaluated 3 to 5 years later to assess the progression of the disease. Objective of this study is to establish a correlation between OA grading in femoropatella joint and patellar malalignmentwith pain and disability using WOMAC Score.Method: Observational analytic study with crosssectional and consecutive sampling was performed in this study. In the WOMAC correlation with KellgrenLawrence grading on the WOMAC OA genu and grading narrowing between joints using the Rank Spearmanwhile the different test WOMAC with malalignment using T test Results: WOMAC OA genu of the grading (AP/LAT/Skyline) r = 0.488; p = 0.003, WOMAC OA genu of the grading (AP/LAT) r = 0.452 ; p = 0.006, WOMAC OA genu of the grading (AP/Skyline) r = 0.362 ; p = 0.033, WOMAC towards narrowing between joints gradingfemoropatella r = 0.370 ; p = 0.026, no differences between patellar malalignment with WOMAC score, with malalignment (p = 0.711) without malalignment(p = 0.751).Conclusion: In AP/LAT/Skyline, AP/LAT, AP/Skyline position and grading narrowing femoropatella joint space was found a significant positive correlation between OA knee’s grading and WOMAC score. No differences in T test between patella malalignment with pain and disability using WOMAC score.Keywords: femoropatella osteoarthritis, patellar malalignment, WOMAC score.
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/6
10.37275/ijr.v8i1.6
Indonesian Journal of Rheumatology; Vol. 8 No. 1 (2016): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v8i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/6/4
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/7
2020-05-07T02:47:35Z
ijr:ORI
Comorbidities in patients with gout in rheumatology clinic Dr. Hasan Sadikin general hospital in 2012 - 2013
Limanjaya, W R
Wachjudi, Rachmat Gunadi
Tansah, H
Background: Gout is a metabolic disease manifested mainly as an intense monoarticular inflammatory reaction which is strongly associated with hyperuricemia. Latest evidence showed that uric acid exerted effects on the development of other diseases. Many studies in developed countries had estimated the frequency of comorbidities associated with gout suchas hypertension, obesity, diabetes mellitus, Chronic Kidney Disease (CKD), and Myocardial Infarct (MCI). However, no data regarding these frequencies have been found in Indonesia up to now to the best of the author’s knowledge. This study aimed to establish thefrequency of these comorbidities in patients with gout in Rheumatology Clinic Dr. Hasan Sadikin General Hospital, Bandung, Indonesia.Methods: All medical records of patients with gout in Rheumatology Clinic Dr. Hasan Sadikin General Hospital from January 2012 to December 2013 were collected. The data on blood pressure; Body Mass Index (BMI); random blood glucose, fasting blood glucose or 2 hourspost prandial blood glucose; history of myocardial infarction; and creatinine were taken and analyzed to determine the presence of comorbidities Results: Among all patients with gout in Rheumatology Clinic Dr. Hasan Sadikin General Hospital, 53.08% had chronic kidney disease, 42.73 % had hypertension, 25.39% had diabetes mellitus, 15.70% had myocardial infarction and 12.22% had obesity.Conclusions: Comorbidities commonly found in patients with gout in order of frequency were chronic kidney disease, hypertension, diabetes mellitus, myocardial infarct, and obesity.Keywords: gout, comorbidities, frequency.
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/7
10.37275/ijr.v8i1.7
Indonesian Journal of Rheumatology; Vol. 8 No. 1 (2016): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v8i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/7/5
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/8
2020-05-07T02:47:35Z
ijr:ORI
Validity test of anti-c1q serum as diagnostic marker for lupus nephritis
Enrica, M
Tjandrawati, A
Rachmayati, S
Hamijoyo, Laniyati
Background: Lupus nephritis is defined as renal involvement in systemic lupus erythematosus (SLE) patients and the most important cause of morbidity and mortality. The diagnostic criteria that used to diagnose lupus nephritis are 1997 American Collegeof Rheumatology is 24 hours urine protein ≥500 mg and/or cellular cast, but significant renal damage can occur without proteinuria or cellular cast. Anti-C1q is an autoantibody that is produced by a chronic alteration of C1q collagen domain. Anti-C1q is a new specific marker for renal marker.Objective: To determine the validity of anti-C1q serum by using 1997 American College of Rheumatology criteria as a gold standard. Methods: This is a cross sectional study, conducted in October to December 2014 at Hasan Sadikin Hospital Bandung. The subjects had systemic lupus erythematosus with and without renal involvement, based on 1997 American College of Rheumatology criteria for SLE.Results: There were 65 subjects included in this study, 64 subjects were female and 1 subject was male. The age average was 32 (SD 11.7) years old. As many as 66.2% subjects had been diagnosed with lupus erythematosus systemic at least 3 years. Twenty four hours urine protein was measured using spectrophotometry, urine sediment was examinedfor cellular cast, and anti-C1q serum was measured using micro enzyme linked immunosorbent assay. Based on American College of Rheumatology criteria, 34 subjects were classified as lupus nephritis group while 31 subjects were classified as non-lupus nephritis group. The area under the curve of anti-C1q was 0.610. The cut-off value used in this study was 10.43 U/ml. The sensitivity, specificity, positive predictive value,negative predictive value and accuracy of anti-C1q assay were 41.18%, 77.42%, 66.67%, 54.55% and 58.46% respectively.Conclusion: Anti-C1q assay, based on this study, hasa low sensitivity and medium specificity to detect lupusnephritis
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/8
10.37275/ijr.v8i1.8
Indonesian Journal of Rheumatology; Vol. 8 No. 1 (2016): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v8i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/8/6
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/9
2020-05-07T02:47:35Z
ijr:ORI
Effectivity and safety of mahkota dewa fruit extract compared to meloxicam (phaleria macrocarpa fructus) on osteoarthritis
Rahmadi, Andri Reza
Dewi, Sumartini
Nawawi, A
Adnyana, I K
Wachjudi, Rachmat Gunadi
Background: Osteoarthritis (OA) is the most common musculoskeletal disease. World Health Organization (WHO) estimates that 10% of the aged over 60 year population have this disease. The aim of OA treatment is to reduce pain, which is the most OA patients chiefcomplaint. People in Indonesia are very interested in use of herbal therapies from original traditional plant to treat pain now, one of the traditional plants that are known havea benefit is Phaleria macrocarpa or Mahkota Dewa fruit. Phaleria macrocarpa has been shown to decrease the degree of inflammation of OA animal model experiments. In order to know what is the effect of this fruit extract to reduce degrees of pain and change the levels of IL-1, IL-6, TNF-α in the blood as the marker of inflammation of patients with knee OA, and what is the effects to liver, kidney and haematology in the Indonesian population hasnot been investigated Methods: The research method is an experimental study and the research design is PROBE (Prospective Randomized Open End Blinded Evaluation), to evaluate the efficacy of the extract Mahkota Dewa fruit (Phaleria macrocarpa fructus) 330 mg (Super Mahkota POMTR 053 345 491) compared to meloxicam 7.5 mg in patients with knee osteoarthritis. The study population was outpatients with knee OA at Rheumatology Clinic Dr Hasan Sadikin Hospital Bandung. Patients are given Phaleria macrocarpa 330 mg or meloxicam 7.5 mg once a day for 14 days. Observations were made to evaluate the degree of pain as measured by VAS and Lequesne index at day 0, day 14 and measured again at day 28,after they are not taking the extract anymore.Results: Phaleria macrocarpa 330 mg is equal to meloxicam 7.5 mg in reducing the degree of pain as measured by VAS (p=0.78) and the Lequesne index (p=0.51). Our finding, t here is no effect of decreasing the proinflammatory cytokine IL-1 (p=0.72), IL-6(p=0.53) and TNF-α (p=0.07) in the blood of both groups. Safety analysis shown that this extract is safe for consumption.Conclusions: Phaleria macrocarpa 330 mg equal to meloxicam 7.5 mg in reducing the degree of pain however there is no effect on reducing proinflammatory cytokines in the blood of OA patients who had received therapy for 14 days in both groups. There is no adverse effects found on hematological, liver function and kidney function after consumption this plant’s fruit extract.Keywords: osteoarthritis, mahkota dewa, phaleria macrocarpa
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/9
10.37275/ijr.v8i1.9
Indonesian Journal of Rheumatology; Vol. 8 No. 1 (2016): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v8i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/9/7
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/10
2020-05-07T02:47:35Z
ijr:ORI
Correlation of Random Urine Protein Creatinine (P-C) Ratio with 24-Hour Protein Urine in Lupus Nephritis Patients
Aini, Y H
Tjandrawati, A
Suraya, N
Hamijoyo, Laniyati
Background : Systemic lupus erythematosus (SLE) is a systemic autoimmune disease involving multiple organs including kidney and known as lupus nephritis (LN). Lupus nephritis has a poor prognosis after a 10-years onset, more than 25% will be ended by end stage renal disease. There are glomerular and tubulointerstitial tissue damages due to immune complex deposits in LN which is activating inflamation cascade and causing disfunction of glomerular filtration and tubular reabsorption resulting proteinuria. In LN, proteinuria is used to diagnose, to assess the disease activity and to monitor the therapy. The gold standard of proteinuria is 24-hour urine protein examination, but the process ofcollecting in 24 hour urine is difficult, then the result is less accurate and reliable. Another alternative parameter is spot urine protein/creatinine ratio. Several studies have found a positive correlation between spot urine protein/creatinine ratio and 24-hour urine protein levels, but in LN, the results are various.Objective: The aim of this study was analyzing the correlation between spot urine protein/creatinine ratio and 24-hour urine protein in lupus nephritis.Methods: The study was conducted at Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia in October 2014 to December 2014. The subjects were 45 patients with lupus nephritis based on the criteria of the American College of Rheumatology. The study analyzedcorrelation through cross-sectional model. Results: The results of Spearman correlation test analysis showed a significantly strong positive correlation between spot urine protein/creatinine ratio and 24-hour urine protein levels in lupus nephritis (rs =0.96; p <0.001). Based on the degree of proteinuria there was a strong positive correlation between spot urine protein/creatinine ratio and 24-hour urine protein levels in lupus nephritis significantly on the degree of protein <1 g/24-h (rs = 0.91; p <0.001) and at 1–3.5 g/24-h (rs = 0.73; p<0.05).Conclusion : There is a significant strong positive correlation between spot urine protein/creatinine ratio and the 24-hour urine protein levels in lupus nephritis, so it is recommended to use spot urine protein/creatinine ratio, as an alternative quantitative examination in lupus nephritis.Keywords: lupus nephritis, 24-hour urine protein, spot urine protein/creatinine ratio
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/10
10.37275/ijr.v8i1.10
Indonesian Journal of Rheumatology; Vol. 8 No. 1 (2016): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v8i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/10/8
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/11
2020-05-07T02:47:35Z
ijr:CAS
Myelopathy caused by Ossification of Thoracic Ligamentum Flavum
Yudoyono, Farid
Dahlan, Rully Hanafi
Ompusunggu, Sevline Esthetia
Hamijoyo, Laniyati
Arifin, Muhammad Zafrullah
Hypertrophy of the posterior spinal elements leading to compromise of the spinal canal and its neural elements is a well-recognized pathological entity affecting the lumbar or cervical spine. Such stenosis of the thoracic spine in the absence of a generalized rheumatological,metabolic, or orthopedic disorder, or a history of trauma is generally considered to be rare. Spinal ligaments, such as the ligamentum flavum (LF), are prone to degeneration and can lead to back pain and nerve dysfunction. Ossification of ligamentum flavum (OLF) is a pathological condition that cause neurological symptoms and usually occurs in the thoracic spine and less frequently in the cervical spine. However the disease is now being increasingly recognized as acause of thoracic myelopathy. We report a rare case of thoracic myelopathy caused by OLF. A 48-year-old male presented with a chief complaint of weakness of bilateral lower extremities. Neurological examination revealed sensory deficit at Th 11 level below. Magnetic resonance imaging and computed tomography demonstrated OLF at the right T9–11 level. Thoracicmyelopathy caused by OLF was consider and surgical intervention was performed. Posterior decompression and laminoplasty has been performed for this patient. Keywords: ossification of ligamentum flavum, thoracic myelopathy, laminoplasty
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/11
10.37275/ijr.v8i1.11
Indonesian Journal of Rheumatology; Vol. 8 No. 1 (2016): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v8i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/11/9
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/12
2020-05-07T02:56:01Z
ijr:REV
Role of leptin in the pathogenesis of systemic lupus erythematosus
Suarjana, I Nyoman
Leptin is a 16 kDa adipocyte-secreted hormone that regulates weight centrally and links nutritional status to neuroendocrine and immune functions. Several studies indicate that leptin plays an important role in immune responses. Leptin affects both innate and adaptive immunity. It can stimulate dendritic cells (DC), monocytes, macrophages, neutrophils and natural killer cells. Leptin is involved in DC maturation and survival,and can skew the cytokine balance of a T helper (Th)1 profi le. In adaptive immunity, leptin can promote naïve T cell survival and production of interferon-γ and interleukin-2, and activate Th1 cells while inhibiting Th2 cells. Leptin may play an important role in theregulation of the Th1/Th2 balance. As a survival factor, leptin has been shown to suppress B cell apoptosis. The role of leptin in the pathogenesis of systemic lupuserythematosus (SLE) is not fully determined yet. This review tries to link the role of leptin in immunity to the pathogenesis of SLE.
Indonesian Rheumatology Association
2018-02-02
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/12
10.37275/ijr.v1i1.12
Indonesian Journal of Rheumatology; Vol. 1 No. 1 (2009): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v1i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/12/10
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/13
2020-05-07T02:56:01Z
ijr:ORI
Risk factors of osteoarthritis that reduce the Steinbrocker’s functional capacity of patients with osteoarthritis of the knee
Setiyohadi, Bambang
Nasution, A R
Isbagio, H
Objective. This study was implemented to determine the risk factors of osteoarthrosis which potentially could reduce the Steinbrocker’s functional capacity (SFC) of patients with osteoarthrosis of the knee.Method. In this cross sectional study, the cases were taken consecutively from the ambulatory patient with the osteoarthrosis of the knee who visited the rheumatologyclinic, Cipto Mangunkusumo Hospital. Subjects was interviewed to record the existing and severity risk factors using a structured questionnaire regarding their age, gender, duration of the illness pattern of smoking history of diabetes mellitus, menopause, body mass index (BMI), knee joint deformity, 15 meters walking time and KellgrenLawrence radiologic index.Results. One hundred thirteen cases of osteoarthrosis of the knee were assigned to the study between July to December 1992, 24 patients were male and 89 werefemale. Eighteen patients were designated to SFC I, 77 patients to SFC II, 14 patients to SFC III and 4 patients to SFC IV. With the logistic regression analysis, it was found that the signifi cant risk factors of developing SFC II, III and IV from patients of SFC I were being female and smoking. In the second logistic regression analysis we found that the signifi cant risk factors for developing SFC III and IV from patients of SFC I and II were age and BMI.Conclusion. In this study we have found that age, smoking, female genders, and BMI were the risk factors which potentially could reduce the SFC of patients withosteoarthrosis of the knee.
Indonesian Rheumatology Association
2018-02-02
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/13
10.37275/ijr.v1i1.13
Indonesian Journal of Rheumatology; Vol. 1 No. 1 (2009): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v1i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/13/11
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/14
2020-05-07T02:56:01Z
ijr:ORI
Risk factors for the development of knee osteoarthritis
Kasjmir, Yoga I
Nasution, A R
Daud, Rizasyah
Objective. This article presents case control study conducted at the Rheumatology Outpatient Unit, Department of Internal Medicine, Cipto Mangunkusumo Hospital. The aim of this study was to determine several risk factors for the development of knee osteoarthritis (OA) at Rheumatology out-patient unit Department of InternalMedicine, Cipto Mangunkusumo Hospital.Method. This study used a case control design. Subjects were divided into two groups, case group and control group. The case group included all patients who had kneecomplaints that fulfi lled the 1990 American College of Radiology criteria while the control group included patients randomly chosen from visitors of the RheumatologyOutpatient Unit of Cipto Mangunkusumo Hospital who did not complain of knee pain and had been proven of not suffering OA by physical and radiological examinations. A similar questionnaire was designed for both groups. After filling out the questionnaire, both groups were examined physically and radiologically. The risk factors were analyzed using logistic regression.Results. We included 127 patients in the case group and 102 in the control group. In the case group, there were 95 women (74.80 %) and 32 men (25.20%) while the control group consisted of 69 women (67.65%) and 33 men (32.35%). From the analysis of several risk factors, there were signifi cant differences between the case and control groups such as weight (p < 0.0001 df 3), prior history of overweight or obesity (x2 = 21.255, df 1, p < 0.0001), knee trauma (p = 0.0002), and kneel down activity (p < 0.0001). There was also a signifi cant difference of smoking habit between the case group and the control group (p < 0.0001). Duration of smoking cessation was also signifi cantly different between the case group and controlgroup (t = 2.315, df 45, p = 0.0252). From the multivariate analysis, it was found that age, kneel down activity, prior obesity condition, interval between knee trauma and onset of OA, smoking habit, and duration of smoking cessation had a signifi cant correlation with knee OA.Conclusion. Age, prior history of overweight or obesity, kneeling, and interval between knee trauma and onset of OA were risk factors of knee OA. Smoking was a negative risk factor for knee OA. The protective effect of smoking was infl uenced by the duration of smoking habit and the duration of smoking cessation.
Indonesian Rheumatology Association
2018-02-02
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/14
10.37275/ijr.v1i1.14
Indonesian Journal of Rheumatology; Vol. 1 No. 1 (2009): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v1i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/14/12
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/15
2020-05-07T02:56:01Z
ijr:ORI
Correlation between serum leptin concentration and disease activity in normal body mass index premenopausal women with systemic lupus erythematosus
Suarjana, I Nyoman
Kasjmir, Yoga I
Isbagio, Harry
Soegondo, S
Background. Leptin is recognized as a cytokine-like hormone with pleiotropic actions in modulating immune responses. The role of leptin in pathogenesis of systemiclupus erythematosus (SLE) was not fully understood yet. Previous study did not fi nd the correlation between serum leptin concentration and disease activity in patients with SLE, but selection of the subjects wasn’t based on the classifi cation of body mass index (BMI) and menopausal status.Objective. To determine correlation between serum leptin concentration and the disease activity in normal BMI premenopausal women with SLE.Methods. Serum leptin concentration was measured by enzyme-linked immunosorbent assay and disease activity was scored using Mexican SLE disease activity index (Mex-SLEDAI). Spearman’s correlation coeffi cient test was used for evaluating the strength of association between leptin level and Mex-SLEDAI score.Results. Seventy normal BMI premenopausal women with SLE were included in this study. The median of serum leptin concentration was 13.4 (0.6 – 45.9) ng/ml.The median serum leptin concentration in patients with active disease was 12.4 (0.6 – 41.6) ng/dl, whereas in patients with inactive disease was 15.2 (3.9 – 45.9) ng/dl.No signifi cant different was found between serum leptin concentration in active and inactive disease (p = 0.14). A weak negative correlation was observed between leptinconcentration and Mex-SLEDAI score, but not statistically signifi cant (r = -0.22; p = 0.07).Conclusion. No correlation was found between serum leptin concentration and disease activity in normal BMI premenopausal women with SLE. Prednisone doses anddisease duration might interfere.
Indonesian Rheumatology Association
2018-02-02
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/15
10.37275/ijr.v1i1.15
Indonesian Journal of Rheumatology; Vol. 1 No. 1 (2009): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v1i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/15/13
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/16
2020-05-07T02:56:01Z
ijr:CAS
Avascular necrosis of the right femoral head in a systemic lupus erythematosus patient
Manuaba, Ida Ayu Ratih Wulansari
Setiyohadi, Bambang
According to the 1993 Association Research Circulation Osseous, idiopathic avascular necrosis of the femoral head is defined as the presence of disease or other causes that result in ischemic osteonecrosis of the femoral head without the presence of trauma or sepsis. Based on the above defi nition, idiopathic avascular necrosis(AVN) includes those that are the result of steroid administration, systemic lupus erythematosus, alcoholic consumption, etc. The pathogenesis of AVN is still obscure; however, it is basically caused by vascular circulation disorder, cell death and decreased capability of bone repair.1,2 Systemic lupus erythematosus (SLE) is characterized by the presence of systemic immune dysregulation, autoantibody formation, immune complex in the circulation, and activation of the systemic complement. The pathology during recurrence of SLE, among others, is the presenceof vascular lesion in the form of infl ammation, thrombosis, endothelial injury in which the three of them are predispositions for atherosclerosis. The vascular lesion will cause microcirculation damage which is a risk factor for the occurrence of AVN in activation of SLE. Besides being caused by vascular lesion during activation of SLE, AVN is also triggered by fat deposition in SLE patients as a result of long term steroid therapy that causes abnormal blood fat level.1,2 Patients with SLE who have undergone pharmacologic treatment with systemic steroid either in oral or injection form will have 10 to 40 times the risk of having idiopathic AVN. High dose of systemic steroid treatment of more than 4000 mg of prednisone administered for more than three months or low dose of oral steroid administered for seven days can become a risk factor for AVN. The mechanism of AVN caused by steroid treatmentis associated with hypercoagulation, fi brinolysis disorder, and thrombosis of the bone vein.1,2,3 We report a case of AVN of the right femoral head in an SLE patient.
Indonesian Rheumatology Association
2018-02-02
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/16
10.37275/ijr.v1i1.16
Indonesian Journal of Rheumatology; Vol. 1 No. 1 (2009): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v1i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/16/14
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/17
2020-05-07T02:56:01Z
ijr:CAS
Knee arthritis in an HIV positive patient - not associated with antiretroviral therapy
Suarjana, I Nyoman
Kasjmir, Yoga I
Setiyohadi, Bambang
Human immunodefi ciency virus (HIV)-associated arthritis is an oligoarthritis which predominantly affect the knees and ankles. It tends to be selflimited and to last less than six weeks. However, some patients with HIV-associated arthritis have been reported to have a disease course of more than six weeks with joint destruction. Synovial fl uid cultures are typically sterile and radiographs of the affected joints are usually normal except in those rare patients with a prolonged duration of symptoms in whom joint-space narrowing can occur.1,2 The pathophysiology of HIV specific arthritis types is not fully understood but drugs of the highly active antiretroviral therapy, in particular indinavir, are supposed to cause arthritis or rheumatological complaints.3 However,recently both human T-lymphotropic virus (HTLV) type I and HTLV-II have been suggested to induce infl ammatory or autoimmune reactions which can increase signifi cantly the incidence of arthritis.4 We report a patient with HIV infection presenting as knee arthritis which was apparently not associated with antiretroviral therapy.
Indonesian Rheumatology Association
2018-02-02
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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https://journalrheumatology.or.id/index.php/ijr/article/view/17
10.37275/ijr.v1i1.17
Indonesian Journal of Rheumatology; Vol. 1 No. 1 (2009): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v1i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/17/15
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/18
2020-05-07T02:56:01Z
ijr:CAS
Systemic sclerosis in two generations family: a mother and offspring
Nilasari, D
Hamijoyo, Laniyati
Kasjmir, Yoga I
Setiyohadi, Bambang
Systemic sclerosis (SSc) is uncommon connective tissue disease characterized by a pathological thickening and tethering of the skin and involvement of internal organ (i.e gastrointestinal tract, heart, lungs, and kidneys). Systemic sclerosis seems to result from a multifactorial process (alteration of the immune system, genetic, and environmental factors) but its pathogenesis remains unclear. A familial history of SSc represents an important risk factor for developing the disease.1 We describe two generations family who developed SSc.
Indonesian Rheumatology Association
2018-02-02
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/18
10.37275/ijr.v1i1.18
Indonesian Journal of Rheumatology; Vol. 1 No. 1 (2009): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v1i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/18/16
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/19
2020-05-07T02:56:01Z
ijr:CAS
Tophi which develop years before the first attack of acute gouty arthritis
Hidayat, Rudy
Kasjmir, Yoga I
Gout is a clinical disease associated with hyperuricemia and caused by the deposition ofmonosodium urate crystals in and around the tissue of joints. The course of classic gout passes through three distinct stages: asymptomatic hyperuricemia, acute intermittent gout, and advanced gout/chronic tophaceous gout.1,2 Tophi; described as accumulation of articular, osseus, soft tissue, and cartilaginous crystalline deposits; is one of clinical manifestation of chronic tophaceous gout stage, and usually developedafter 10 or more years of acute intermittent gout.1,2 Although patients have been reported with tophias their initial clinical manifestation
Indonesian Rheumatology Association
2018-02-02
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/19
10.37275/ijr.v1i1.19
Indonesian Journal of Rheumatology; Vol. 1 No. 1 (2009): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v1i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/19/17
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/20
2020-05-07T02:55:26Z
ijr:REV
Vitamin D and inflammation
Albar, Zuljasri
The discovery that most body cells and tissues have vitamin D receptors and that some of them have the enzymatic machinery to convert the circulating form of vitamin D (25-hydroxyvitamin D) into the active form (1,25- dihydroxyvitamin D/1,25(OH)2D3 ) gave a new insight about the function of this vitamin. In the course of time, more and more evidences showed that a low vitamin D level leads to the occurrence or recurrenceof cardiovascular diseases, type II diabetes mellitus (DM), cell dedifferentiation (oncogenesis), and immune derangement (autoimmune diseases such as lupus, typeI DM, rheumatoid arthritis, and multiple sclerosis). Most researchers have agreed that a minimum 25(OH)D3 serum level of about 30 ng/ml or more is necessary for favorable calcium absorption and good health. Until proven otherwise, the balance of the research clearly indicates that oral supplementation in the range of 1,000 IU/day for infants, 2,000 IU/day for children, and 4,000 IU/day for adults is safe and reasonable to meetphysiologic requirements, to promote optimal health, and to reduce the risk of several serious diseases.
Indonesian Rheumatology Association
2018-02-06
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/20
10.37275/ijr.v2i1.20
Indonesian Journal of Rheumatology; Vol. 1 No. 2 (2009): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v2i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/20/18
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/21
2020-05-07T02:55:26Z
ijr:ORI
Hyperuricemia and Pro Inflammatory Cytokine (IL-1β, IL-6, and TNF-α)
Hadi, Suyanto
Sudarsono, D
Suntoko, Bantar
Background. Rugerio et al 2006 reported that there were a positive correlation between the level of hyperuricemia and the level of IL-1β, IL-6, and TNF-α pro infl ammatory cytokines value. On the other hand, Choi et al reported a negative correlation between hyperuricemia and the level of pro infl ammatory cytokine in the late phase of hyperuricemia.Methods. Venous blood samples were collected and stored at a temperature of - 80oC from in- and outpatients with hyperuricemia with age of more than 17years old at Dr. Kariadi Hospital, Semarang. The level of uric acids (mg/dl) were examined with enzymatic colorimetric technique (Roche Diagnostics) whereasthe levels of IL-1β, IL-6, and TNF-α pro infl ammatory cytokines (pg/ml) were examined with enzyme linked immunosorbent assay (ELISA) technique using ultrasensitive commercial kit (Human ultra sensitive, Biosource International Inc Europe), and ELX 800, 2002 machine. The normality of the data was tested withOne-Sample Kolmogorov-Smirnov technique and the correlation was tested with Spearman correlation (data with abnormal distribution) or Pearson correlation (datawith normal distribution).Results. There was a weak positive correlation between the level of hyperuricemia and the level of IL-1 β cytokine in Spearman correlation test with r value = 0.246 and p value > 0.05 in Spearman correlation test. On the other hand, there was a weak negative correlation between the level of hyperuricemia and the level of TNF-α cytokine with r value = - 0.096 and p value > 0.05. There was also weak negative correlation between the level of hyperuricemia and the level of IL-6 cytokine with r value = - 0.072 and p value > 0.05 in Pearson correlation test.Conclusion. There was a weak positive correlation but not sifnificant between the level of hyperuricemia and the level of IL-1β.
Indonesian Rheumatology Association
2018-02-06
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/21
10.37275/ijr.v2i1.21
Indonesian Journal of Rheumatology; Vol. 1 No. 2 (2009): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v2i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/21/19
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/22
2020-05-07T02:55:26Z
ijr:ORI
Correlation between anti-cyclic citrullinated peptide antibodies and the severity of clinical manifestation, laboratory manifestation, and radiological joint destruction in rheumatoid arthritis patients
Suwito, Mat
Handono, Kusworini
Suryana, Bagus Putu Putra
Kalim, Handono
Wahono, Cesarius Singgih
Background. The second generation anti-cyclic citrullinated peptide test (CCP2) displays sensitivity comparable to that of rheumatoid factor (RF) (approximately 80%) but with superior specificity (98%) . Several observations have indicated that early rheumatoid arthritis (RA) patients with positive anti-CCP may develop a more erosive disease than those without anti-CCP.Objective. The purpose of this cross-sectional study was to investigate the correlation between anti-CCP antibodies and clinical and laboratory parameters and radiological joint destruction in RA patients.Methods. We studied 31 patients with RA fulfilling the 1987 revised criteria of American College of Rheumatology in Rheumatology Clinic of Saiful Anwar General Hospital, Malang, Indonesia. Clinical parameters were collected such as age, sex, visual analog scale,disease duration and diseases activity score (DAS28-3(CRP)). Laboratory parameters were WBC, hemoglobin, platelet count, erythrocyte sedimentation rate, and Creactive protein. Analyzed autoantibody profiles were RF and anti-CCP (ELISA methode). Radiological jointdestruction was evaluated from bilateral postero-anterior manus x ray (Sharp score).Results. Anti-CCP antibodies were detected in 48.4% of RA patients with mean antibody concentration was 291.24±143.67 (range 16-523.8) units. Anti CCP level was significantly correlated with duration of RA (month) (p=0.04, r=0.371), RF level (p=0.002, r=0.542) andSharp score (p=0.048, r=0.358), but was not significantly correlated with other clinical and laboratory parameters.Conclusion. Anti-CCP level was correlated with duration of disease, RF, and Sharp score.
Indonesian Rheumatology Association
2018-02-06
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/22
10.37275/ijr.v2i1.22
Indonesian Journal of Rheumatology; Vol. 1 No. 2 (2009): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v2i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/22/20
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/23
2020-05-07T02:55:26Z
ijr:ORI
Profile of osteophyte location in different grades of functional status in patients with knee osteoarthritis
Mesanti, O
SETIYOHADI, BAMBANG
Kasjmir, Yoga I
Budihusodo, U
Oemardi, M
Background. Osteophyte is a reparative response to cartilage breakdown in osteoarthritis (OA) and osteophyte formation is a knee stabilizing factor. Disability could be found in patients with knee OA. Objective. To identify the profile of osteophyte formation (location, size, and direction) based on knee radiograph and functional status examination in knee OA patients who presented to the Rheumatology Clinic, Cipto Mangunkusumo Central National General Hospital.Methods. Samples were taken by consecutive approach. Knee radiographs (weight bearing anteroposterior and30 degrees flexion skyline views) and functional status examinations were performed on 100 patients with knee OA (90 females and 10 males with ages ranging from 51 to 74 years old). A radiologist assessed films for osteophyte profile such as location, size, and direction according to standard atlas. One knee with the severe radiological assessment based on OA grade was selected from one patient to be the profile. LequesneAlgofunctional Index was also taken from the patients. Results. The site of osteophyte in patients with knee OA was mostly found at lateral femur (85/100 subjects). Based on specific location, grade 2 osteophyte at lateral femur was the most frequent size (49/100 subjects) and osteophyte extending toward the lower middle atlateral patella (65/100 subjects) was the most frequent direction of osteophyte. The most frequent profile for size and direction of osteophyte at specific location was the grade 2 osteophyte extending toward the lower middle at lateral patella (35/100 subjects). Severe functional status impairment was found in 53% of the patients. The most frequent functional status found according to specific location of osteophyte was severe functionalstatus impairment in patients with oste ophyte at lateral femur (46/100 subjects). The most frequent functional status of OA patients based on the size and direction of osteophyte at specific location was the severe functional impairment in the patients with grade 2 osteophyte at lateral femur (27/100 subjects) and the patients with osteophyte extending towards the lower middle at lateral patella (37/100 subjects) respectively.Conclusions. Osteophyte at lateral femur, osteophyte at lateral tibiofemoral compartment, grade 2 osteophyte at lateral femur, and osteophyte extending toward the lower middle at lateral patella were the profiles of osteophyte which mostly showed severe functional status impairment in patients with knee OA.
Indonesian Rheumatology Association
2018-02-06
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/23
10.37275/ijr.v2i1.23
Indonesian Journal of Rheumatology; Vol. 1 No. 2 (2009): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v2i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/23/21
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/24
2020-05-07T02:55:26Z
ijr:CAS
Diabetes insipidus in neuropsychiatric-systemic lupus erythematosus patient
Pangestu, Y
Wardoyo, A
Wijaya, Linda K
SETIYOHADI, BAMBANG
Albar, Zuljasri
Sukmana, N
Budiman, Budiman
Djoerban, Z
Effendy, S
Aziza, L
Sitorus, F
Systemic lupus erythematosus (SLE) is an idiopathic autoimmune chronic inflammatorydisease that is unique in its diversity of clinical manifestations, variability of disease’s progression, and prognosis. The disease is characterized by the remission and multiple flare-ups in between the chronic phase that may affect many organ systems.The prevalence of SLE in the US population is 1:1000 with a woman to man ratio of about 9-14:1. At Cipto Mangunkusumo Hospital, Jakarta in 2002, there was 1.4% cases of SLE of the total number of patients at the Rheumatology Clinic. Neuropsychiatric manifestations of SLE (NP-SLE) have a high mortality and morbidity rates. The incidence of NP-SLE ranges 18-61%. Diagnosis of NP-SLE is difficult because there is no specific laboratory examination. Accordingly, in all SLE patients with central nervous system (CNS) dysfunction, additional tests will be necessary to confirm an NP-SLE diagnosis and exclude other causes. Similar to diabetes insipidus, SLE is a systemic disease which affects many organ systems, one being the endocrine system. No data has specified the occurrence rate of diabetes insipidus in SLE patients. This disease arises from a number of factors able to interfere with the mechanism of neurohypophyseal renal reflex resulting in the body’s failure to convert water.3 There are three general forms of the disease, a polydipsicpolyuric syndrome caused by partial/complete vasopressin deficiency (central-diabetes-insipidus/CDI), vasopressin resistance of the kidney tubules (nephrogenic-diabetes-insipidus/NDI), and primary polydipsia. CDI occurs in about 1 in 25,000 persons
Indonesian Rheumatology Association
2018-02-06
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/24
10.37275/ijr.v2i1.24
Indonesian Journal of Rheumatology; Vol. 1 No. 2 (2009): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v2i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/24/22
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/25
2020-05-07T02:55:26Z
ijr:CAS
Osteoarticular tuberculosis of the right foot: a diagnostic delayed
Akil, Natsir
Setiyohadi, Bambang
Lubis, A MT
Fawziah, A
Extrapulmonary tuberculosis (TB) involving the musculoskeletal system occurs in approximately 1% to 3% of patients with extrapulmonary TB. Concurrent pulmonary or intrathoracic TB is present in less than 50% of cases.1 Spine is the most frequent site of osseous tuberculous involvement. Other affected sites include the hip, knee, foot, elbow, hand, and bursal sheaths.2 Tuberculosis of the foot and ankle remains anuncommon site of the infection, present in 8% to 10% of osteoarticular infection. The diagnosis of osteoarticular tuberculosis is often delayed due to a lack of familiarity with the disease.3 We describe a patient with foot pain and swelling without any respiratory symptom as initial presentation of pulmonary and osteoarticular tuberculosis
Indonesian Rheumatology Association
2018-02-06
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/25
10.37275/ijr.v2i1.25
Indonesian Journal of Rheumatology; Vol. 1 No. 2 (2009): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v2i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/25/23
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/26
2020-05-07T02:55:26Z
ijr:CAS
Septic arthritis caused by Salmonella sp
Hambali, Wirawan
Sumariyono, Sumariyono
Chen, K
Septic arthritis is a rare joint disorder, and can be caused by various pathogenic microorganisms, including bacteria, virus, mycobacterium, and fungus. The incidence of this infection is between 2 to 10 cases per 100,000 populations annually andcan reach as high as 30 to 70 cases per 100,000 in immunodeficient population. This disorder is frequently unidentified in early phase of the disease due to its unspecific symptoms and signs.1 This joint infection can cause numerous problems to the patient ranging from joint damage, bone erosion, osteomyelitis, fibrosis, ankylosis, sepsis,or even death.1-5 The case-fatality rate for this disorder can reach up to 11%, comparable to the case fatality rate for other community infections such as pneumonia.2,6 Salmonella sp. is a Gram-negative bacillus bacterium with main invasion predilection in intestinal villi.7 This microorganism rarely causes septic arthritis although several cases have been reported before. Ortiz-Neu et al. demonstrated that septic arthritis caused by Salmonella sp. has high relapse incidence and a tendency to turnchronic, making the treatment more difficult and challenging
Indonesian Rheumatology Association
2018-02-06
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/26
10.37275/ijr.v2i1.26
Indonesian Journal of Rheumatology; Vol. 1 No. 2 (2009): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v2i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/26/24
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/27
2020-05-07T02:55:26Z
ijr:CAS
Chronic polyarthritis mimicking rheumatoid arthritis in a patient with leprosy
Haribowo, A S
Suryana, Bagus Putu Putra
Handono, Kusworini
Currently leprosy is now still a global threat in the world even after the introduction of multidrug therapy (MDT), including in Indonesia.1 World Health Organization (WHO) data revealed that in 2002 there were 597,000 cases worldwide and the prevalence is only less than 1 every 10,000 populations.2 Nevertheless, the latest data showedthat 83% of leprosy cases concentrated in only 6 countries: Indonesia, India, Brazil, Madagascar, Myanmar, and Nepal.3 The most common manifestations of leprosyare cutaneous and neuritic manifestation. Rheumatologic manifestation is another common manifestation of leprosy.4-7 Prevalence of rheumatologic manifestation of leprosy is range from 1% to 77% of all leprosy patients.4-11 Study conducted by Mandal et al in India revealed that the prevalence of rheumatologic manifestation was 5.9%, in Brazil,6 another study by Pereira revealed the prevalence of 9.1%.5 Hadi, in Indonesia,showed the prevalence of arthritic manifestation was 7.5%.8 Rheumatologic manifestations that can be found in leprosy are polyarthritis or oligoarthritis, soft tissue rheumatism, noninflammatory arthritis, and also enthesitis.4-7 We report a patient presenting with polyarthritis as the primary manifestation of leprosy.
Indonesian Rheumatology Association
2018-02-06
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/27
10.37275/ijr.v2i1.27
Indonesian Journal of Rheumatology; Vol. 1 No. 2 (2009): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v2i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/27/25
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/28
2020-05-07T02:55:26Z
ijr:CAS
Calcinosis and myocarditis in systemic lupus erythematosus patient
Dewi, Sumartini
Wachjudi, Rachmat Gunadi
Systemic lupus erythematosus (SLE) patients have multi-organ involvement related to their chronic inflammatory, autoimmune disease. Calcinosis can be clinical manifestations of SLE. Tissue calcinosis is reported in approximately 17% patients and myocarditis in 20-55% patients. Thus, both manifestations are not unusual in SLE. Tachypnea, tachycardia, pericardial effusion, and wheezing are often present and can be misleading in SLE patient.1,2 Calcinosis is less common in SLE, sometimesit is found as an incidental radiological finding. Calcification in SLE maybe periarticular, within joints or muscles, or in the subcutis (calcinosis universalis).1 Calcinosis is classified into four subsets: dystrophic, metastatic, idiopathic, or calciphylaxis/iatrogenic. When calcinosis cutis is isolated to a small area in extremities and joints, it is called calcinosis circumscripta; whereas its diffuse form, refers to calcinosis universalis, affects subcutaneous and fibrous structures of muscles and tendons. The pathophysiology of this condition is unknown and no effective therapy is currently available.3,4,5 Systemic lupus erythematosus can involve the myocardium, pericardium, cardiac valves,and coronary arteries. Myocarditis in SLE is not likely to produce major regional wall motion abnormalities but may contribute to global left ventricular dysfunction.7,8We report a young woman with SLE who developed calcinosis and myocarditis.
Indonesian Rheumatology Association
2018-02-06
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/28
10.37275/ijr.v2i1.28
Indonesian Journal of Rheumatology; Vol. 1 No. 2 (2009): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v2i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/28/26
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/29
2020-05-07T02:57:19Z
ijr:REV
Role of interleukin-17 in the pathogenesis of rheumatoid arthritis
Ongkowijaya, Jeffrey A
Setiyohadi, Bambang
Sumariyono, Sumariyono
Kasjmir, Yoga I
Rheumatoid arthritis (RA) is a systemic autoimmune disorder with an unknown etiology. It typically affects the peripheral synovial joints symmetrically. The roles of T and B cells, macrophages, plasmocytes, host tissue cells (synoviocytes, chondrocytes), and osteoclastsin RA are more defi ned. In RA, cytokines secreted by cells implicated in adaptive and natural immunity have important roles in causing infl ammation, articular destruction, and other comorbid diseases related to RA. Other than the clear roles of interleukin (IL)-1 and tumor necrosis factor α, there are other cytokines that are suspected of having roles in the pathogenesis of RA, IL-17 for instance. Interleukin-17 is a proinfl ammatory cytokine, produced by Th17 cells, and has pleiotropic effects on various cells contributing to the pathogenic condition of RA. Several studies showed that this cytokine maintains the infl ammation and causes more destruction of joint cartilage. Advances in the understanding of the role of IL-17 elicits the idea to modulate IL-17 and/or Th17 cells as the potential targetsof therapy in RA
Indonesian Rheumatology Association
2018-02-07
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/29
10.37275/ijr.v2i2.29
Indonesian Journal of Rheumatology; Vol. 2 No. 1 (2010): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v2i2
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/29/27
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/30
2020-05-07T02:57:19Z
ijr:ORI
Correlation of autoantibodies with the Disease Activity Score 28 and radiographic hand joint damage in rheumatoid arthritis patients
Manuaba, Ida Ayu Ratih Wulansari
Sumariyono, Sumariyono
Isbagio, Harry
Background: Rheumatoid arthritis (RA) is a systemic chronic infl ammatory disease of the joint that causes deformity or disability leading to a decreased function in RA patients. According to the 1987 American College of Rheumatology, rheumatoid factor (RF) is used as one of the diagnostic criteria because until today it is still considered as the primary autoantibody in RA although it has a lower specifi city than that of anticyclic citrullinated peptide (anti-CCP). Besides RF and anti-CCP, anti-RA33 is another autoantibody found. Thepresence of the three autoantibodies in RA patient serum is important because it is the starting point of the pathogenesis of the autoimmune process in RA.Methods: This is a cross-sectional study using consecutive sampling. Forty six subjects, all suffering from RA, were recruited for this study. All of them were tested for RF, anti-CCP, anti-RA33 titers using enzymelinked immunosorbent assay (ELISA) method and hadtheir hand radiograph taken to obtain the Sharp score to evaluate joint damage. During this study, 28-joint Disease Activity Score (DAS28) (4 parameters) was also evaluated using erythrocyte sedimentation rate as one of the parameters.Results: The study found that the correlation between the three antibodies and DAS28 was not statistically signifi cant: RF (r = 0.200, p = 0.091), anti-CCP (r =0.117, p = 0.220), and anti-RA33 (r = 0.126, p = 0.202). There was a signifi cant correlation between antiCCP and the Sharp score (r = 0.300, p = 0.021). The correlation between the other two autoantibodies and the Sharp score was not statistically significant:RF (r = 0.194, p = 0.098), anti-RA33 (r = 0.156, p = 0.150).Conclusion: There was a signifi cant correlation between anti-CCP autoantibody and radiographic hand joint damage in RA patients so that it could be used as an indicator for occurrence of an erosive or a more severe RA.
Indonesian Rheumatology Association
2018-02-07
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/30
10.37275/ijr.v2i2.30
Indonesian Journal of Rheumatology; Vol. 2 No. 1 (2010): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v2i2
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/30/28
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/31
2020-05-07T02:57:19Z
ijr:ORI
Predictor of joint damage in rheumatoid arthritis
Sumariyono, Sumariyono
Isbagio, H
Objective: This study was implemented to determine the joint damage predictor in rheumatoid arthritis (RA).Methods: A cross-sectional study was conducted on outpatients of the rheumatology clinic at Cipto Mangunkusumo General Hospital who had suffered from RA for more than 2 years during the period from October 1, 1999 to June 30, 2000. During this period, we obtained 23 RA patients who fulfi lled the inclusion and exclusion criteria. We evaluated the patients’ medical data that included gender, education, age of onset, rheumatoid factor (RF), C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR). Then we carriedout examinations and tests including X-ray of hand and wrist joints, RF, CRP, and ESR. The degree of joint damage was evaluated using the Larsen score.Results: Twenty three patients—all women, mean age of onset was 36.7 years, mean duration of disease was 62.8 months, educational level with high school degree or above were found in 19 cases (82.6%), and RF (+) at initial treatment were found in 10 cases (43.5%). The mean ESR at initial treatment was 77.9 mm/hr and CRP at initial treatment was between 0 and 768 mg/dL. The Larsen score ranged between 0 and 68 with a meanof 21.7. In bivariate analysis, the Larsen score was signifi cantly higher in the group with positive RF at initial treatment compared to that in the group with negative RF at initial treatment (p = 0.031). C-reactive protein and ESR at initial treatment and the age of onset did not have any signifi cant correlation with the Larsen score, but there was a signifi cant correlation of CRP and ESR during the study with the the Larsen score.Conclusion: RF level was the most signifi cant predictor in determining the degree of joint damage according to the Larsen score while initial positive RF had lower signifi cance level.
Indonesian Rheumatology Association
2018-02-07
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/31
10.37275/ijr.v2i2.31
Indonesian Journal of Rheumatology; Vol. 2 No. 1 (2010): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v2i2
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/31/29
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/32
2020-05-07T02:57:19Z
ijr:ORI
Correlation of matrix metalloproteinase-9 level, erythrocyte sedimentation rate, rheumatoid factor, and the duration of illness with radiological findings in rheumatoid arthritis patients
Aji, G
Manuaba, Ida Ayu Ratih Wulansari
Ongkowijaya, Jeffrey A
Setiyohadi, Bambang
Sumariyono, Sumariyono
Background: Rheumatoid arthritis (RA) is a common autoimmune disease of the joint indicated by chronic inflammation of synovium, cartilage destruction, and osteopenia. The end results of RA are joint deformity and disability that will decrease the quality of life ofthe patients. Until now there is not a specifi c marker to assess the process of joint and bone damage in RA. Available markers such as C-reactive protein and erythrocyte sedimentation rate (ESR) indicate more about the infl ammatory status of the patient. Thediscovery of matrix metalloproteinases (MMPs) enzyme overexpression in RA has brought a new hope for the discovery of more specifi c markers of joint damage.Objective: To study the correlation of MMP-9 level, ESR, rheumatoid factor (RF), and the duration of illness with joint damage in RA patients.Methods: A cross-sectional study was conducted on RA outpatients in rheumatology clinic at Cipto Mangunkusumo General Hospital, Jakarta from January to October 2009. From the patients who fulfilled the inclusion criteria and did not fulfi ll the exclusion criteria, blood sample was collected for MMP-9 level, RF, and ESR examinations; hand radiography (posterior-anterior view) was also taken. Results: From the study of 46 patients, we found a significant correlation between MMP-9 level and radiographic feature of bone erosion (r = 0.3, p = 0.02) and between the duration of illness and Sharp score (r = 0.36, p = 0.014). There was no correlation between ESR and radiological fi ndings nor between RF and radiological fi ndings. Linear regression analysis showed the duration of illness as the most infl uencing factor toradiological fi ndings in RA patients.Conclusion: We found a signifi cant correlation between MMP-9 level and radiographic feature of bone erosion, and between the duration of illness and radiological fi ndings in RA patients.
Indonesian Rheumatology Association
2018-02-07
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/32
10.37275/ijr.v2i2.32
Indonesian Journal of Rheumatology; Vol. 2 No. 1 (2010): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v2i2
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/32/30
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/33
2020-05-07T02:57:19Z
ijr:ORI
Atherosclerosis prevalence and the correlation between atherosclerosis risk factors and carotid intima-media thickness in below 40-year-old women with systemic lupus erythematosus
Sari, R M
Kasjmir, Yoga I
Antono, D
Setiati, S
Objectives: To determine the prevalence of atherosclerosis in female systemic lupus erythematosus (SLE) patients aged below 40 years old and the factors correlated with carotid intima-media (CIM) thickening.Methods: A cross-sectional study was conducted on 80 female SLE respondents aged below 40 years old who were either in- or outpatient of Cipto Mangunkusumo General Hospital, Jakarta. History of disease and treatment was taken, and laboratory test and ultrasonography of the carotid artery to evaluate CIM thickness were performed.Results: The prevalence of atherosclerosis was 40%, comprising of CIM thickening and/or presence of atherosclerotic plaque in the carotid artery. The median values of CIM thickness in the right common carotid artery, right carotid bulb, left common carotid artery, and left carotid bulb were 0.040 cm, 0.04535 cm, 0.0430 cm, and 0.047 cm, respectively. There was also a positive correlation reported of CIM thickness with increased age, the duration of SLE disease, and the duration of steroid treatment.Conclusions: We found a positive correlation of CIM thickness with age, the duration of SLE disease, and the duration of steroid treatment in female SLE patients aged below 40 years.
Indonesian Rheumatology Association
2018-02-07
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/33
10.37275/ijr.v2i2.33
Indonesian Journal of Rheumatology; Vol. 2 No. 1 (2010): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v2i2
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/33/31
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/34
2020-05-07T02:57:19Z
ijr:CAS
Arthritis in leprosy without specific skin lesion
Dewi, Sumartini
Setiyohadi, Bambang
Leprosy patients could display a great variability of signs and symptoms. An overabundance of rheumatic manifestations, occuring alone or in varying combinations, are associated with leprosy, particularly with lepra reactions A study involving seventy cases of leprosy found that rheumatic manifestations were seen in 61.42% of cases: arthritis in 54.28% and soft tissue rheumatism in 17.14%. Enthesitis was seen in 2.84% of cases. Rheumatic manifestations may be the primary complaint, thus delaying accurate diagnosis. Musculoskeletal involvement in leprosy is the third most frequent manifestation after dermatological and neurological involvements. It can occur at anytime during the infection. Articular inflammation in leprosy, which closely mimics other rheumatic disorders, usually occurs in reactive states, particularly erythema nodosum leprosum (ENL).1 About 1–5% of leprosy patients are reported of developing arthritis (synovial inflammation) at some stage of the disease but this rate increases to over 50% during lepra reactions.2 Here we report a case of arthritis in leprosywithout any typical skin lesion thus causing a delay in diagnosis.
Indonesian Rheumatology Association
2018-02-07
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/34
10.37275/ijr.v2i2.34
Indonesian Journal of Rheumatology; Vol. 2 No. 1 (2010): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v2i2
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/34/32
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/35
2020-05-07T02:57:19Z
ijr:CAS
Complete manifestations of Behçet’s disease
Umami, V
Setiyohadi, Bambang
Behçet’s disease (BD) is a chronic, relapsing, inflammatory disease characterized by recurrent oral aphthae and any of several systemic manifestations that include genital aphthae, ocular disease, skin lesions, neurologic disease, vascular disease, or arthritis. Hippocrates may had described BD in the fifth century B.C.; however, the first official description of the syndrome was attributed to the Turkish dermatologist Hulusi Behçet in 1924. In 1930, the Greek physician Adamantiades reported a patient with inflammatory arthritis, oral and genital ulcers, phlebitis, and iritis.1 Since then, the syndrome has been referred to as BD.1,2 The manifestations of BD are thought to be caused by an underlying vasculitis. Although this disease is recognized worldwide, the prevalence is highest in the eastern Mediterranean, the Middle Eastern, and East Asian countries, thus the nickname Silk Road disease. The disease tends to be more severe in areas where it is more common. Prevalence rates all over the world are increasing, probably because of improved recognition and reporting. Behçet’s disease occurs primarily in young adults. The mean age at onset is between 25 and 30 years. The incidence of disease in males and females is approximately equal along the Silk Road, but in Japan, Korea, and Western countries the disease occurs more frequently in women. Caseconfirmation can be challenging because many patients labeled as having BD have oral ulcers as the primary or sole manifestation.3
Indonesian Rheumatology Association
2018-02-07
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/35
10.37275/ijr.v2i2.35
Indonesian Journal of Rheumatology; Vol. 2 No. 1 (2010): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v2i2
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/35/33
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/36
2020-05-07T02:57:19Z
ijr:CAS
Erosive osteoarthritis
Ongkowijaya, Jeffrey A
Setiyohadi, Bambang
Sumariyono, Sumariyono
Osteoarthritis (OA) is a degenerative joint disease characterized by the erosion of cartilage joints, hypertrophy of the marginal bone, subchondral sclerosis, and the morphological and biochemical changes of synovial membrane and joint capsule.This clinical syndrome is characterized by joint pain caused by degeneration of the joints. It is the most common joint disease to afflict the elderly and it occurs more often with age.1–3 Erosive osteoarthritis is a subset of OA in which there is a destruction of the joints as a result of inflammation.3,4 Changes mainly occur on the distal interphalangeal (DIP) joints, proximal interphalangeal (PIP) joints, carpometacarpal (CMC) joints, and very rarely occur on other joints of hand or of other body parts.3–5 The diagnosis is in accordance with the criteria of American College of Rheumatology (ACR) for OA and is supported by the existence of bone erosion on the radiological image. The management of this disease is merely for palliative purpose.
Indonesian Rheumatology Association
2018-02-07
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/36
10.37275/ijr.v2i2.36
Indonesian Journal of Rheumatology; Vol. 2 No. 1 (2010): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v2i2
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/36/34
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/37
2020-05-07T02:57:19Z
ijr:CAS
Multiple autoimmune syndrome (Graves’ disease, systemic lupus erythematosus, and systemic sclerosis) in a young woman in Jakarta
Dewi, Sumartini
Setiyohadi, Bambang
Mokoagow, M I
Multiple autoimmune syndrome (MAS) is a condition in which patients have at least threedistinct autoimmune conditions. The definition of MAS is based on 91 reported cases of such associations in the literature. A review of the literature and cluster analysis of MAS disclosed systemic lupus erythematosus (SLE), Sjögren’s syndrome, and autoimmune thyroid disease (AITD) as the “chaperones†of autoimmune diseases. This entity was described by Humbert and Dupond in 1988 as a syndrome consisting of the presenceof three or more autoimmune diseases in a single patient. While describing the syndrome, their observations led them to a rough classification of clusters based on the co-occurrence of autoimmune disease, which they identified as types one through three.1 In MAS-1, the authors grouped myasthenia gravis, thymoma, dermatopolymyositis, and autoimmune myocarditis together. In MAS-2, they grouped Sjögren’s syndrome, rheumatoid arthritis,primary biliary cirrhosis, systemic sclerosis (SSc), and AITD. MAS-3 consists of AITD, myasthenia gravis and/or thymoma, Sjögren’s syndrome, pernicious anemia, idiopathic thrombocytopenic purpura, Addison’s disese, type 1 diabetes, vitiligo, autoimmune hemolytic anemia, and SLE.1,2,3 The importance of this concept is the probability thathaving three autoimmune diseases simultaneously in one patient goes beyond epidemiological inferences or statistical chance. Disorders of autoimmune pathogenesis occur with increased frequency in patients with a history of another autoimmune disease. The tendency to develop another disease occurs in about 25% of these patients.3,4 We report a case in which the presence of Graves’ disease/AITD, SLE, vasculitis, and SSc with pulmonary hypertension and Raynaud’s phenomenon in one patient
Indonesian Rheumatology Association
2018-02-07
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/37
10.37275/ijr.v2i2.37
Indonesian Journal of Rheumatology; Vol. 2 No. 1 (2010): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v2i2
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/37/35
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/38
2020-05-07T02:54:05Z
ijr:REV
Risk of cardiovascular disease in rheumatoid arthritis patients
Utari, A P
Hidayat, Rudy
Setiyohadi, Bambang
Despite rheumatoid arthritis (RA) therapy development has been in advance level today, its mortality remains increasing in general population. The mortality is mainly caused by early-manifested atherosclerosis and other cardiovascular complications. Available evidences showthis condition appears in early stage of the disease. Thus, early detection and management of cardiovascular risk, followed by control of these factors are necessaryto reduce morbidity and mortality of RA patients
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/38
10.37275/ijr.v3i1.38
Indonesian Journal of Rheumatology; Vol. 3 No. 1 (2011): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v3i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/38/36
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/39
2020-05-07T02:54:05Z
ijr:ORI
Knee function measured by timed up-and-go test and stair-climbing test after isometric exercise of quadriceps femoris muscles in female patients with knee osteoarthritis
Widjanantie, S C
Tulaar, A BM
Kasjmir, Yoga I
Prasetyo, S B
Background: Osteoarthritis (OA), the most common form of joint disease, can result in long-term disability. Limitation of activity in OA patients may result in a decline in the strength of quadriceps femoris muscles and thus further reduce mobility. Isometric exercise has been known to increase muscle strength, decrease pain, and improve knee function.Objective: To evaluate knee function measured by timed up-and-go test (TUGT) and stair-climbing test (SCT) as well as muscle strength in the fourth and sixth week after isometric exercise of quadriceps femoris muscles and the correlation between these variables.Methods: Female patients with OA underwent isometric exercise of quadriceps femoris muscles 3 times a week for 6 weeks. Muscle strength (measured by tensiometer cable) and knee function (measured by TUGT and SCT) were evaluated before and at week 4and 6 of the exercise.Results: Thirty fi ve female patients were recruited in this study. The majority of the patients (45.7%) were between 60 to 65 years old. Obesity was found in 62.86% of the patients. At week 6, there was significant decrease in mean TUGT and SCT (by 39.0% and 45.6%, respectively; p<0.001), and signifi cant increase in mean right and left quadriceps muscles strength (by 47.9% and 36.7%, respectively; p<0.001). There was a weaknegative correlation (nonsignifi cant) of the increased strength of quadriceps muscles with the increase of knee function according to TUGT (right leg: r = -0.172, p = 0.323; left leg: -0.303, p = 0.077) and SCT (right leg: r = -0.031, p = 0.860); left leg: r = -0.058, p = 0.742).Conclusion: In female patients in this study, significant improvement was found in the strength of quadriceps muscles, TUGT, and SCT after 6 weeks of isometric exercise. There was no signifi cant correlation between muscle strength and knee function according to TUGT and SCT.
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/39
10.37275/ijr.v3i1.39
Indonesian Journal of Rheumatology; Vol. 3 No. 1 (2011): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v3i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/39/37
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/40
2020-05-07T02:54:05Z
ijr:ORI
Comparison of ultrasound therapy and local steroid injection in rotator cuff tendinitis
Noviar, Noviar
Tulaar, A BM
Kasjmir, Y I
Sudarsono, S
Objective: To evaluate the effectiveness of ultrasound therapy compared with local steroid injection for pain relief and movement limitation in rotator cuff tendinitis.Methods: Patients with rotator cuff tendinitis at the rheumatology and rehabilitation outpatient clinic at Cipto Mangunkusumo General Hospital were enrolled in a parallel randomized trial, in which each eligible patient were randomly assigned to one of two groups: one group received 10 sessions of ultrasound therapy given in 2 weeks, the other received a single dose of local steroid injection. Evaluation of the visual analog scale(VAS) was performed in 10 days (5 days for each week: day 1–5 and 8–12), while evaluation of the abduction as well as external and internal rotation range of motion(ROM) was performed twice a week (day 2, 5, 9, and 12). Change in the variables between the two groups at the end of the second week (day 12) was then compared. Results: Thirty patients, divided into two groups consisting of 15 patients each, were recruited in the study. Significant decrease in VAS during the followups was obtained in both groups, slightly earlier in the steroid injection group (day 2; p = 0.041) comparedwith the ultrasound group (day 3; p = 0.001). Significant increase in abduction ROM was achieved at the same rate (beginning at day 5) in both groups. Significant increase in internal rotation ROM was achieved at day 9 in the ultrasound group (p = 0.043) and day 12 in steroid injection group (p = 0.044). The increase in external rotation ROM in both groups was not found to be statistically signifi cant. At the end of the second week, signifi cant difference between the two groups was only shown in the abduction ROM, with higherincrease in the steroid group.Conclusions: Ultrasound therapy provided a comparable effectiveness to steroid injection inalleviating pain and improving ROM in patients with rotator cuff tendinitis.
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/40
10.37275/ijr.v3i1.40
Indonesian Journal of Rheumatology; Vol. 3 No. 1 (2011): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v3i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/40/38
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/41
2020-05-07T02:54:05Z
ijr:ORI
Comparison of the prevalence of hyperuricemia in families of patients with and without gouty arthritis among Balinese people
Kambayana, Gede
Putra, T R
Background: Gout is a metabolic disorder caused by hyperuricemia, which results from changes in uric acid metabolism. Both internal (e.g., genetics) and external factors (e.g., diet, habits, comorbidities) play role in the occurrence of hyperuricemia and the difference of hyperuricemia prevalence in different populations.Objective: To compare the prevalence of hyperuricemia in families of gout and non-gout patients among Balinese people.Methods: This cross-sectional study was carried out at the rheumatology clinic at Sanglah Hospital, Denpasar. Samples were collected using consecutive method and consisted of gout and non-gout patients. Several characteristics (alcohol and purine consumption,medications, blood pressure, body mass index, serum uric acid level, and serum creatinine) in both groups were collected and compared. Family members (fi rstdegree relatives) of patients in each group were also recruited and had their serum uric acid level measured and compared.Results: A total of 46 patients and 116 family members (23 patients and 58 family members in each group) were enrolled. Among gout patients, there was signifi cantlyhigher prevalence of hyperuricemia, serum uric acid level, blood pressure, and serum creatinine; and lower creatinine clearance compared with the non-gout patients. There was signifi cantly higher prevalence of hyperuricemia among families of gout patients comparedwith families of non-gout patients (60.3 vs. 29.3%, respectively; p = 0.001), with a prevalence ratio of 2.06. Mean serum uric acid level of the family members of gout patients were also signifi cantly higher than the family members of non-gout patients (7.24 (SD 1.74) vs. 5.92 (SD 1.63) mg/dL, respectively; p = 0.000).Conclusion: Among Balinese people in this study, significantly higher prevalence of hyperuricemia and mean serum uric acid level was observed in families of gout patients compared with families of non-gout patients.
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/41
10.37275/ijr.v3i1.41
Indonesian Journal of Rheumatology; Vol. 3 No. 1 (2011): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v3i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/41/39
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/42
2020-05-07T02:54:05Z
ijr:ORI
Diagnostic criteria of knee osteoarthritis in rheumatology outpatient clinic, Dr. Sardjito Hospital, Yogyakarta
Kertia, Nyoman
Wachid, Deddy Nur
Krishnan, P N
Background: Osteoarthritis (OA) is a chronic condition characterized by the breakdown of joints cartilage. Approximately 25% of persons 55 years of age or older have knee pain on most days and about half of them have radiographic OA in the knee. Prevalence of knee OA increases with age and it is more common in women than men. It is not easy to establish the diagnosis of knee OA since other knee disorders have similar clinicalsigns and symptoms.Objective: The purpose of this study was to observe the diagnosis pattern of knee OA in rheumatology outpatient clinic at Dr. Sardjito Hospital based on clinical and radiographic criteria of American College of Rheumatology (ACR). Method: The design of this study was cross-sectional. Data of the patients with knee OA were investigated from their medical records. Results: There were 212 subjects diagnosed with knee OA during the year 2000–2010. Most of the subjects (90.56%) were more than 50 years old. Women were more frequent affected by OA than men. All of the subjects (100%) had knee pain. Crepitus was found in98.11% subjects. Morning stiffness less than 30 minutes was found in 86.79% subjects. Osteophyte appearances were found in 79.72% subjects.Conclusion: Knee pain, crepitus, and age more than 50 years old were the most frequent criteria used to diagnose knee OA. Morning stiffness less than 30 minutes and osteophyte appearances were also frequent in knee OA.
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/42
10.37275/ijr.v3i1.42
Indonesian Journal of Rheumatology; Vol. 3 No. 1 (2011): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v3i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/42/40
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/43
2020-05-07T02:54:05Z
ijr:CAS
Experience with cyclophosphamide in the treatment of a young woman with refractory dermatomyositis
Setiyohadi, Bambang
Sinto, R
Dermatomyositis is an idiopathic inflammatory myopathy characterized by the presence of rash and moderate-to-severe muscle weakness secondary to inflammation of the muscle. It can be a difficult condition to treat. Systemic corticosteroids are the first choice of treatment. However, about a quarter of patients either fail to respond to steroids or develop steroid-related toxicity. Second-line agents such as azathioprine and methotrexate are then added either alone, or in combination with corticosteroids. Failure of the disease to respond tosecond-line agents can then be a problem and this is often referred to as “refractory dermatomyositisâ€. Unfortunately, there is neither agreement nor wellestablished guidelines on the best regimen or combination of immunosuppressive agents in the case of refractory dermatomyositis.
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/43
10.37275/ijr.v3i1.43
Indonesian Journal of Rheumatology; Vol. 3 No. 1 (2011): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v3i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/43/41
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/44
2020-05-07T02:54:05Z
ijr:CAS
Sclerodermatomyositis
Febyani, M
D, H Purbo
Hamijoyo, Laniyati
Sutedja, E
Suwarsa, O
The classification of rheumatic diseases is still challenging due to several reasons. First, those diseases have several differential clinical features, which giving overlap symptoms. Second, the etiopathogenesis of those diseases remains elusive.Diagnosis of overlap syndrome is made when there are more than one well-defined connective tissue diseases in one patient, which may develop simultaneously or sequentially.1,2 The prevalence of overlap syndrome among autoimmune diseases is25%.2 The term sclerodermatomyositis or scleromyositisis is used to describe an overlap syndrome in patients with scleroderma and dermatomyositis/polymyositis (DM/PM).2,3,4 Sclerodermatomyositis usually affects adults, and it is rarely found in children.4 The clinical features of this syndrome are myalgia or myositis, arthralgia, scleroderma-like skin changes, Raynaud’s phenomenon (RP),2,3 interstitial lung disease, calcinosis,3 mask-like facies, dysphagia or esophageal dysmotility,4 as well as the presence of specific antibody Pm/Scl.2 Skin manifestations as the part of dermatomyositis include periorbital erythema and Gottron’s papules.3 We report this case due to its very rare occurrence. According to medical records in the Department of Dermatology as well as Rheumatology at Hasan Sadikin Hospital, Bandung, this is the first case recorded in the last 10 years.
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/44
10.37275/ijr.v3i1.44
Indonesian Journal of Rheumatology; Vol. 3 No. 1 (2011): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v3i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/44/42
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/45
2020-05-07T02:54:05Z
ijr:CAS
Septic arthritis in malignancy
Setiyohadi, Bambang
Santosa, D
Titis, Titis
Abdullah, A A
Septic arthritis is an infection of a joint, which canbe caused by bacteria, viruses, fungi, or parasites. The infection may happen in distant sites of the body, which then spread hematogenously, or it could also result from open wounds, surgery, or unsterile injections.1 Septic arthritis is a serious condition that, if left undiagnosed and untreated, can cause joint destruction and an irreversible loss of joint function.2,3 Based on epidemiological data, the incidence of septic arthritis in general population is 2–10 cases in 100,000 people annually and is increased in those who have risk factors for septic arthritis, such as rheumatoid arthritis (RA) and joint prosthesis. In those with RA, the incidence of septic arthritis rises up to 30–70 cases in 100,000 people annually, and in those with prosthesis the figure is around 40–68 cases in 100,000 people annually.4,5 Septic arthritis can affect all age groups, but it is more prevalence in the elderly and in children under 5 years old, in which the prevalence is 8.4 and 5 cases, respectively, in 100,000 people annually.5 Septic arthritis is usually monoarticular, whereas polyarticular involvement occurs in only 10–15% of cases. The knee is involved in around 50% of cases.Septic arthritis is still a challenge for cliniciansince there has not been a significant decline in both morbidity and mortality in the last two decades.2 Late recognition and therapy can cause permanent joint dysfunction and even death; thus, early diagnosis and prompt therapy is expected to decrease the morbidity and mortality rate in septic arthritis.6 In this case report we would like to present a case of a woman suffering from septic arthritis with an underlying immunocompromised condition of malignancy
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/45
10.37275/ijr.v3i1.45
Indonesian Journal of Rheumatology; Vol. 3 No. 1 (2011): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v3i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/45/43
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/46
2020-05-07T02:50:40Z
ijr:REV
Pathogenesis of atherosclerosis in rheumatoid arthritis
Pambudi, Joko Rilo
Isbagio, Harry
Increased morbidity and mortality in patients with rheumatoid arthritis (RA) is largely associated with cardiovascular disease. In this case, the factors that play a role is chronic inflammation. A chronic inflammatory associated with condition which accelerate atherosclerosis and increased cardiovascular morbidity and mortality. Inflammatory and atherogenic mediators have a role in pathogenesis of RA and atherosclerosis. Atherogenesis in RA start when cytokines from the inflamed synovial tissue are released into the systemic circulation. Circulating cytokines affects the function of other tissues such as adipose tissue, skeletal muscle, liver and vascular endothelium that would lead to proatherogenic transformation process such as insulin resistance, prothrombotic effects, pro-oxidative stress and endothelial dysfunction. Size, weight and durationof systemic inflammatory response in RA are the most important factor causing damage. IMT (Intima Media Thickness) measurement on common carotid arteries byB-mode ultrasound is a rapid non-invasive examination of the structural anatomy, reproducible and relatively low risks that are advantageous for assessing therisk of cardiovascular disease and monitoring disease progression.
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/46
10.37275/ijr.v5i1.46
Indonesian Journal of Rheumatology; Vol. 5 No. 1 (2014): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v5i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/46/44
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/47
2020-05-07T02:50:40Z
ijr:ORI
Association Between Adiponectin Levels with Markers of Atherosclerosis In Patients with Rheumatoid Arthritis
Meriza, Tanggo
Isbagio, Harry
Mulyadi, Rahmad
Abdullah, Murdani
Background: Several studies have shown that atherosclerosis underlying processes of Cardiovascular disease (CVD), increased in rheumatoid arthritis (RA) and occurred early (premature). The cause of accelerated atherosclerosis in RA are still unknown.Adipokines have known that the adipokines play a role in the pathophysiology of RA and CVD. Accumulation of visceral fat associated with dysregulation of adipokinesthat influence the development of the atherosclerotic and disruption plaque. Obesity and pathological changes in fat mass and fat dysfunction as well as a change inthe pattern of secretion of proinflammatory adipokines, may have a correlation between heart disease and rheumatic diseases. Adiponectin is one of the mostwidely-studied adipokines. In RA, adiponectin is involved in the pathophysiology of RA that produces of various proinflammatory and prodestructive molecules. So far, adiponectin has been known to provide antiatherosclerotic effects in patients with non-RA. But, several recent studies in RA patients get opposite results in which increased levels of adiponectin are associated with increased prevalence of atherosclerosis. The effect of adiponectin on atherosclerosis in patient with RA is still unknown.Objective: to determine the relationship of adiponectin with atherosclerosis in patients with rheumatoid arthritis. Methods: This is a cross-sectional study conducted on outpatients of the rheumatology clinic at Cipto Mangunkusumo General Hospital from January untilApril, 2013. Subjects consisted of 50 patients were diagnosed based on ACR 1987/EULAR 2010 criteria. The collection of data obtained by consecutive sampling and evaluated the patients’ medical data that included age, long-suffering of RA, body mass index (BMI), lipid profile, rheumatoid factor levels, levels of anti-cyclic citrullinated peptide (anti-CCP), C-reactive protein (CRP), erythrocyte sedimentation rates (ESR), blood pressure, fasting blood glucose, 2 hour post prandial blood glucose, ECG, examination of serum adiponectin levels and bilateral carotid ultrasound to measure the carotid artery intima media thickness.Results: From the results of the 50 patients studied, obtained 28 (56%) of patients had increased levels of adiponectin. Atherosclerosis was found in 13 (26%) subjects. The median value was 9.46 μg / ml with the lowest levels of 4 μg/ml and the highestlevels of 24μg/ml. The Spearman’s test showed no significant correlation between adiponectin serum and atherosclerosis in patients with RA (p = 0706 and r = 0.055). The analysis results of the correlation of adiponectin with atherosclerosis based on age, disease duration, ESR, rheumatoid factor, DAS 28, CRP, BMI, dyslipidemia showed no significant correlation.Conclusion : From this study, researchers found no statistically significant correlation between adiponectin levels with marker of atherosclerosis (CIMT) in patients with rheumatoid arthritisKeywords : Adiponectin, Atherosclerosis
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/47
10.37275/ijr.v5i1.47
Indonesian Journal of Rheumatology; Vol. 5 No. 1 (2014): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v5i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/47/45
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/48
2020-05-07T02:50:40Z
ijr:ORI
The Effect of Vitamin D Supplementation on Disease Activity and Neutrophyl-Lymphocyte Count Ratio in Systemic Lupus Erythematosus Patients with Hypovitaminosis D : A Preliminary Study
Maslim, Y
Dewi, Sumartini
Oehadian, A
Wachjudi, Rachmat Gunadi
Background : Previous studies showed a significant role of Vitamin D in modulating inflammation and immune abnormality in SLE. The correlation between vitamin D supplementation and SLE disease activity remains controversy. Neutrophyl-Lymphocyte count Ratio (NLCR) as an inflammation marker was significantly increased in SLE patients.Objective : To evaluate the effect of vitamin D supplementation on disease activity and neutrophyllypmhocyte count ratio (NLCR) in SLE patients with hypovitaminosis D.Methods : This is a pre-post test study without control group using a consecutive sampling method. SLE patients were enrolled from Rheumatology Clinic of HasanSadikin General Hospital from November 2013-March 2014. Subjects received vitamin D3 2000 IU/day for 3 months. Data was analyzed using Wilcoxon test.Results : We analyzed 28 subjects with 89,3% of vitamin D deficiency and 10,7% of vitamin D insufficiency, which converted to 25% of vitamin D deficiency, 32,1% vitamin D insufficiency and 42,9% normal vitamin D plasma level at the end of the study.After supplementation, Mexican Systemic Lupus Erythematosus Disease Activity Index (MEX-SLEDAI) and NLCR was significantly decreased (median 4(3-8) to 2(0-6) and median 2,95(1,17-7,27) to 2,28 (1,07-4,87), p<0,001, respectively). SLE organ involvement such as mucocutan, hematology and renal also high BMI (>23 kg/m2) were risks of hypovitaminosis D. Vitamin D supplementation increased mean 25(OH)D serum level by 164,7%, 46,7% decreased of MEX-SLEDAI, and 24,2% decreased of NLCR (p<0,001). Nine subjects (32,1%) achieved remission, 19 subjects (67,9%) atdisease persistence and no subjects experienced flare up after supplementation.Conclusion : The effects of vitamin D3 2000 IU/day supplementation for 3 months are reduced disease activity and NLCR in SLE patients with hypovitaminosisD. The role of NLCR as a simple inflammation marker in this pilot study needs further investigation.
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/48
10.37275/ijr.v5i1.48
Indonesian Journal of Rheumatology; Vol. 5 No. 1 (2014): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v5i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/48/46
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/49
2020-05-07T02:50:40Z
ijr:ORI
Correlation between Severity of Knee Osteoarthritis and Serum Levels of Cartilage Oligomeric Matrix Protein
Kambayana, Gede
Kurniari, Pande
Andriyasa, Andriyasa
Putra, T R
Background: The sensitivity of radiographic examination in the diagnosis and severity assessment of knee osteoarthritis (OA) is still low. Various attempts have been made to find more reliable indicators of cartilage damage. One potential marker is cartilage oligomeric matrix protein (COMP), a substance that in previous animal studies had been shown to be released in proportion to the extent of joint cartilage damage.Objective: To evaluate the correlation between the severity of knee OA and serum level of COMP in human with normal renal function. Methods: This was a cross-sectional study performed at the outpatient clinic in Department of Internal Medicine, Sanglah Hospital, Denpasar. The diagnosis of knee OA was based on the American College of Rheumatology (ACR) criteria. The degreeof knee OA severity was determined by using the Kellgren-Lawrence criteria, while COMP values were checked by enzyme-linked immunosorbent assay (ELISA) method.Results: Forty five patients who were recruited were examined: 19 (42.2%) were female and 26 (57.8%) were male. The mean age of patients was 64.1±7.1 years. There were 4.4%, 26.7%, 46.7%, and 22.2% patients who had grade 1st, 2nd, 3rd, and 4th degree joint damage based on the Kellgren-Lawrence score, respectively. Mean serum level of COMP was 1081.4 ng/mL. We found a significant correlation ofthe severity of knee OA with serum level of COMP (r = 0.41, p = 0.005).Conclusion: Among the patients in this study, there was a significant correlation between the severity of joint damage in knee OA and serum level of COMP.
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/49
10.37275/ijr.v5i1.49
Indonesian Journal of Rheumatology; Vol. 5 No. 1 (2014): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v5i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/49/47
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/50
2020-05-07T02:50:40Z
ijr:CAS
Osteoarticular Tuberculosis: A Secondary Manifestations to Tuberculous Pleural Effusion
Singh, Gurmeet
Rumende, Cleopas M
Setyohadi, Bambang
Tuberculosis appears to be increasing throughout the world after years of continuous decline, despite the introduction of effective chemotherapy. This resurgence is related to the increasing number of patients immunocompromised by chemotherapeutic agents used to treat other diseases or Acquired Immunodeficiency Syndrome (AIDS); the appearance of multiple drug-resistant strains of tuberculosis, and aging population. Musculoskeletal tuberculosis arises from haematogenous seeding of the bacilli soon after the initial pulmonary infection.1 Osteoarticular TB can occur in the knee - one study found of 1074 cases, 8.3 percent - or 90 cases - affected the knee.2 The clinical symptoms are insidious onset, pain, swelling of the joint and limited range of movements. Investigations for suspected cases include: Mantoux test, radiological imaging, fine needle aspiration biopsy, surgical biopsy, bacteriological examination, histopathological examination, and polymerase chain reaction (PCR) of a suitable specimen. The mainstay of treatment is multidrug antitubercular chemotherapy. The main reason for poor outcome is delayed diagnosis.1 We report a case of osteoarticular manifestation of tuberculosis infection affecting the left knee presenting in a man with a history of tuberculosis pleural effusion. This case highlights, firstly, osteoarticular disease is always secondary to a primary lesion in the lung and, secondly, the diagnosis of tubercular arthritis can be challenging, particularly in the presence of confounding factors such as preexisting arthritis. Ethical approval was not required for this case study.
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/50
10.37275/ijr.v5i1.50
Indonesian Journal of Rheumatology; Vol. 5 No. 1 (2014): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v5i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/50/48
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/51
2020-05-07T02:50:40Z
ijr:CAS
Chronic Osteomyelitis of Wrist Joint in An Immunocompromised Host
Utari, Amanda P
Oktavia, Dina
Sumaryono, Sumaryono
Setyohadi, Bambang
Osteomyelitis is heterogenous in its pathophysiology, clinical presentation, and management. Osteomyelitis is generally categorized as acute or chronic based on histopathologic findings, rather than duration of the infection. Necrotic bone ispresent in chronic osteo-myelitis, and symptoms may not occur until six weeks after the onset of infection.1 Epidemiology of chronic osteomyelitis is less well characterized compared with acute osteomyelitis. Adult osteomyelitis most commonly arisesfrom open fractures, diabetic foot infections, or the surgical treatment of closed injuries. Hematogenous osteomyelitis accounts for approximately 20% of cases of osteomyelitis in adults. It is more common in males regardless of age. Although rare in adults,it most frequently involves the vertebral bodies.2 S.aureus is the most common isolate in all types of bone infection and is implicated in 50-70% of cases of chronic osteomyelitis.3
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/51
10.37275/ijr.v5i1.51
Indonesian Journal of Rheumatology; Vol. 5 No. 1 (2014): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v5i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/51/49
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/52
2020-05-07T02:50:40Z
ijr:CAS
Avascular necrosis of the right femoral head in female patient with Systemic Lupus Erythematosus
Sinaga, A
Nufus, H
Setiyohadi, Bambang
Avascular necrosis (also known as osteonecrosis, aseptic necrosis, or ischemic necrosis) represents collection of pathologic conditions from various etiologies causing impairment of blood supply to particular bone resulting in bone cellular death.Avascular necrosis remains a significant cause of morbidity in patients with systemic lupus erythematosus (SLE).1 It often involves multiple joints in SLE, in which the femoral head is involvedin most of these patients. Corticosteroids use is known as a major risk factor in the development of this complication.2-3 We report this case due to its quite common occurrence in SLE patients. The early recognition of avascular necrosis is essentialto prevent morbidity
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/52
10.37275/ijr.v5i1.52
Indonesian Journal of Rheumatology; Vol. 5 No. 1 (2014): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v5i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/52/50
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/53
2020-05-07T02:47:00Z
ijr:ORI
Do we need to perform bilateral hip bone mineral density examination?
Widjanarko, Annisa Layalia
Background: Bone mineral density (BMD) measurement is one of the method for making osteoporosis diagnosis. World Health Organization (WHO) recommends the measurement of BMD conducted at antero-posterior lumbar vertebrae, unilateral hip (femur), and radius. However, there was a concern about osteoporosis under diagnosis if the measurement is only conducted at unilateral hip. Some studies found significant differences of BMD between both femur and evidence of the importance to examine both femur in making the diagnosis of osteoporosis. This study aims to determine anydifference between right and left femur BMD measurement and to investigate the bone status result with measurement of BMD of bilateral femur in Hasan Sadikin General Hospital. Methods: A retrospective study was conducted from June to November 2015. Patients who received dual-femur BMD testing using General Electrics (GE) Lunar Prodigy dual-energy x-ray absorptiometry at the DXA Facility in Hasan Sadikin General Hospital,Bandung between January 1, 2006 to December 31, 2014 were included. Statistical analysis performed to assess the difference and the correlation between theBMD of two femurs (g/cm2). T-scores of the subject were implemented into bone status according to WHO Diagnostic Criteria for Osteoporosis.Results: From sixty-one patients included in this study, there were difference bone status resulted from BMD of the femoral neck, Ward’s triangle, trochanter, andtotal hip area between right and left femur, although no statistically significance were found. There was a positive correlation between BMD of right and left femurat all areas of femur. There were 16 subjects (26.1%) showed combination level of bone status (normal, osteopenia, or osteoporosis in one femur).Conclusion: BMD results in each area of the right and left femurs are different.Therefore, performing bilateral hip BMD examination as a routine measurement for makingdiagnosis of osteoporosis is important.Keywords: Bone Mineral Density, Dual-energy X-ray Absorptiometry, Femur, Osteoporosis
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/53
10.37275/ijr.v8i2.53
Indonesian Journal of Rheumatology; Vol. 8 No. 2 (2016): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v8i2
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/53/51
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/54
2020-05-07T02:47:00Z
ijr:ORI
Diagnostic values of DAS28 and DAS28-squeeze in evaluating Rheumatoid Arthritis disease
Santosa, David
Hidayat, Rudy
Prasetyo, Marcel
Nugroho, Pringgodigdo
Background : In recent years, rheumatoid arthritis (RA) uses a “treat to targetâ€Â treatment strategy. This strategy requires a valid and accurate tool for assessing disease activity. The most widely used tool is DAS28, which was developed from DAS with the omission of ankle and foot joints. There has been many critization aboutthe accuracy of DAS28 in classifying the state of RA disease. Most importantly, when an active disease state was misclassified as an inactive state (false negative)which lead to under treat and subsequently to disability. The difference between DAS28 and DAS lies mainly in the exclusion of ankle and foot joints, thus DAS28-squeeze, a new and simple tool has been proposed. It comprises the same 28 joints in DAS28 added with a sqeeze test on both metatarsophalangeal joints. However, this new tool has never been validated with any imaging techniques.Objective : To assess the diagnostic values of DAS28 and DAS28-squeeze.Methods : This study comprised a cross-sectional diagnostic study, using Power Doppler sonography as a standard reference in evaluating the diagnostic value ofDAS28 and DAS28-squeeze. This study uses the most sringent sonography criteria of active disease which is an active Doppler signal with a moderate synovial hypertrophy on B-mode. Results : Over the study period, 56 subjects underwent diagnostic tests using DAS28, DAS28-squeeze and Power Doppler sonography. There were 4 false negativecases in DAS28 and 1 case in DAS28-squeeze. The sensitivities of DAS28 and DAS28-squeeze to identify active disease using Power Doppler sonography as reference standard were 73.3% (95%CI ± 11.59) and 93.3% (95%CI ± 6.55), respectively. While the specificities of DAS28 and DAS28-squeeze were 36.6% (95%CI ± 12.62) and 34.1% (95%CI ± 12.42), respectively. Furthermore the negative likelihood ratioof DAS28 and DAS28-squeeze were 0.73 and 0.19, respectively.Conclusion : This study is the first to validate DAS28- squeeze using imaging techniques. From this study the false negative rate of DAS28-squeeze is lower thanDAS28. DAS28-squeeze has a better sensitivity and negative likelihood ratio than DAS28 in identifying RA disease state.Keywords : Rheumatoid Arthritis, DAS28, DAS28-squeeze, treat to target, Power Doppler, squeeze test
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/54
10.37275/ijr.v8i2.54
Indonesian Journal of Rheumatology; Vol. 8 No. 2 (2016): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v8i2
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/54/52
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/56
2020-05-07T02:47:00Z
ijr:ORI
Predictor Factors of Atherosclerosis and Atherosclerosis Plaque in Rheumatoid Arthritis Patients
Pambudi, Joko Rilo
Isbagio, Harry
Mulyadi, Rahmad
Abdullah, Murdani
Background: Atherosclerosis and cardiovascular diseases have been known as the cause of increasing mortality among rheumatoid arthritis (RA) patients. Carotid intima media thickness (CIMT) measurement by ultrasound has been used as surrogate marker of atherosclerosis and cardiovascular disease.Methods: A cross sectional study of 86 RA patients fulfills EULAR/ACR 2010 critera for RA was conducted to study proportion and predictor factors of atherosclerosis and atherosclerosis plaque in rheumatoid arthritis patients.Results: Atherosclerosis and plaque was found in 47,7% and 29 % of patients. Age ≥ 40 yo, hypertension and duration of illness ≥ 24 mo were associated with atherosclerosis in multivariate logistic regression analysis with OR 10.70 (95% CI: 2.93-39.10), 4.99 (95% CI: 1.15-21.61) and 3.66 (95% CI: 1.11-11.99) respectively. Whereas hypertension, presence of antiCCP antibody and age ≥ 40 yo, were associated with plaque formation with OR 3.96 (95% CI: 1.15-13.57), 3.20 (95% CI: 1.11-9.24) and 3.61 (95% CI: 1.03-12.63) respectively.Conclusions: Age ≥ 40 yo, hypertension and duration of illness ≥ 24 mo was the predictors ofatherosclerosis, while hypertension, presence of antiCCP antibody and age ≥ 40 yo was the predictors of atherosclerosis plaque.Key words: atherosclerosis, intima media thickness, predictor, rheumatoid arthritis, ultrasonography.
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/56
10.37275/ijr.v8i2.56
Indonesian Journal of Rheumatology; Vol. 8 No. 2 (2016): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v8i2
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/56/54
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/57
2020-05-07T02:47:00Z
ijr:ORI
Correlations between osteoartritis grading in femorotibial joint (kellgren lawrence) with cartilage defects grading
Permatasari, Yuliati
Zulqarnain, Nasirun
Sukmaningtyas, Hermina
Suntoko, Bantar
Background : Osteoarthritis (OA) is the most common chronic rheumatic diseases that causing pain and disability. The imaging of knee OA were found in 15,5%Â men and 12,7% women of Indonesia population. Radiography is still used as a standard modalities in assesing OA progression, and Kellgren-Lawrence scale (KL) is the most common measurement used byclinicians. Superficial cartilage degradation is the first sign of OA, the early detection of the superficial cartilage degradation is very important for diagnosis. Our study was established to assess the correlation between OA grading in femorotibial joint examined by standard Kellgren-Lawrence scale (KL) measurement with cartilage defects examined by ultrasound.Methods : Observational analytic study with cross sectional and consecutive sampling was performed. Rank Spearman test for correlation of OA grading, cartilage defect, BMI and joint malalignment. McNemar test for correspondence between the location of the narrowing of the femorotibial joint and location of cartilage defects.Result : Correlation of OA grading of femorotibial joints (KL) with cartilage defects grading on ultrasound resulted r =0.459, p<0.05; correlation of OA grading of femorotibial joints (KL) with BMI or joint malalignment resulted p>0,05; correlation of cartilage defect grading with BMI or joint malalignment also resulted p>0.05. McNemar test for location of the narrowing of thefemorotibial joint with location of cartilage defects on ultrasound resulted p = 1.00, k = 0.714. There was a significant positive correlation of OA grading of femorotibial joints (KL) with cartilage defects grading on ultrasound. There was no significant correlation between OA grading of femorotibial joints (KL) with BMI and joint malignment, and no significant correlationbetween cartilage defects grading with BMI and joint malalignment. There is a correspondence between the location of the narrowing of the femorotibial joint with location of cartilage defects on ultrasound.Conclusion: For assesing the grade of osteoartritis, cartilage defect grading and assesment by ultrasound can be used as an alternative to X-Ray KellgrenLawrence scale (KL) measurement.Keywords : femorotibial joint, cartilage defects grading, osteoartritis grading examination, BMI, joint malalignment.
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/57
10.37275/ijr.v8i2.57
Indonesian Journal of Rheumatology; Vol. 8 No. 2 (2016): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v8i2
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/57/55
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/58
2020-05-07T02:47:00Z
ijr:ORI
24-Hour Proteinuria Weakly Correlated with Estimated Glomerular Filtration Rate in Lupus Nephritis Patients
Praptama, Suhendra
Aini, Yulia Hayatul
Ghozali, Mohammad
Hamijoyo, Laniyati
Background: Lupus Nephritis (LN) is still the most frequent complication in Systemic Lupus Erythematous (SLE) patients which causing the major and significance morbidity and mortality. Proteinuria and Glomerular Filtration Rate (GFR) serves as objective and routine examinations to assessrenal function. 24-hour proteinuria still regarded as gold standard to quantify amount protein in urine. Estimated GFR (eGFR) is preferably used due its convenient. On the hand, estimated GFR (eGFR) is preferably used due its convenient. However, both of them should be measured in order to determine renal progression and prognosis. Only few studies have been conducted to find out the correlation between 24-hour proteinuria and eGFR in lupus nephritis patients as both of them serve as potential marker in progression of renal involvement. Thisstudy addressed to find out correlation between 24-hour proteinuria and eGFR in lupus nephritis patients.Method: Analytic-correlation study with cross-sectional approach at Dr. Hasan Sadikin Hospital, Bandung was done. Secondary data was used and paralleled with previous study entitled “Correlation of Random Urine Protein Creatinine (P-C) Ratio with 24-Hour Protein Urinein Lupus Nephritis Patients†carried out from October to December 2014.Correlation coefficient was analyzed by Spearmans’ correlation test.Results: Forty five samples were obtained based on inclusion criteria. Spearmans’ correlation test revealed non significant and very weak correlation between 24-hour proteinuria and eGFR (r=-0.095) with p>0.05.Conclusion: The 24-hour proteinuria and eGFR are weakly correlated. Despite the weak correlation, these examinationsshould be considered as important markers to monitor prognosis of renal involvement in lupus nephritis patients Keywords: Estimated glomerular filtration rate (eGFR),Lupus Nephritis (LN), Proteinuria, Systemic Lupus Erythematosus (SLE).
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/58
10.37275/ijr.v8i2.58
Indonesian Journal of Rheumatology; Vol. 8 No. 2 (2016): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v8i2
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/58/56
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/59
2020-05-07T02:47:00Z
ijr:ORI
Effect of vitamin D supplementation on disease activity (SLEDAI) and fatigue in Systemic Lupus Erythematosus patients with hipovitamin D: An Open Clinical Trial
Rifa’i, Achmad
Kalim, Handono
Kusworini, Kusworini
Wahono, Cesarius Singgih
Background : Low level of vitamin D impact the disease activity and the degree of fatigue in SLE patients. This study aims to determine the effect of vitamin D supplementation on disease activity and fatigue condition in Systemic Lupus Erythematosus (SLE) patients with hipovitamin D.Methods: We performed an open clinical trial. Subjects were randomized into two different groups (supplementation or placebo) using simple random sampling. The treatment group got vitamin D3 softgel/ cholecalciferol 1200 IU/day or 30 mg/day, while the control group gotplacebo for 3 months. SLEDAI scores and FSS scores were calculated at pre and posttreatment.Results: There were 20 subjectsfor supplementation group and 19 subjects in the placebo group. From this study, before and after treatment, we found a significant difference of mean level of vitamin D in supplementation group (p=0.000), and no significant difference inpatients with placebo (p=0.427). Moreover, from the SLEDAI score analysis, observed a significant difference bothin the supplemented group (p=0.000) and the placebo group (p=0.006). FSS scores significantly different in the supplemented group (p=0.000). Incorrelation test,there was a negative correlation (r=-0763) between vitamin D level and disease activity (SLEDAI), and both showing stastistical significance between thepre supplementation (p=0.000) and post supplementation (r=-0846; p=0.000). Similarly to theFSS scores, there was a meaningfulnegative correlation (r=-0.931, p=0.000) between the level of vitamin D with FSS scores pre and post supplementation (r=-0.911; p= 0.000). Furthermore, there was a significant correlation between disease activity (SLEDAI) pre supplementation with fatigue condition pre supplementation (r=0.846; p = 0.000) and postsupplementation (r=0.913; p= 0.000).Conclusion: The supplementation of vitamin D 1200 IU per day in patients with SLE improve disease activity and degree of fatigue. Keywords: vitamin D, disease activity, fatigue, SLE
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/59
10.37275/ijr.v8i2.59
Indonesian Journal of Rheumatology; Vol. 8 No. 2 (2016): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v8i2
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/59/57
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/60
2020-05-07T02:47:00Z
ijr:ORI
Validity And Reliability Of Lupus Quality Of Life Questionnaire In Patients With Systemic Lupus Erythematosus In Indonesia
Anindito, Bagus
Hidayat, Rudy
Koesnoe, Sukamto
Dewiasty, Esthika
Background: The development of Systemic Lupus Erythematosus (SLE) treatment has led the increased of patients survival. Quality of life has became a value based medicine component that should be evaluated in treating SLE. One standardized questionnaire to asses the quality of life in SLE patients is Lupus Quality of Life (Lupus QoL). Currently, in Indonesia, there has not been any spesific questionnaire to asses the quality of life in SLE patients. This study aims to prove that Lupus QoL is valid and reliable to asses the quality of life in SLEpatients in Indonesia.Methods: This study used cross sectional study method. Firstly, we translated the Lupus QoL into Indonesian language, then we tested to 10 respondents. Then, we continued the study with larger sample size. We analyzed the reliability of the test and the re-test result using the interclass coefficient correlation and the internal consistency of the tests using cronbach alpha. Construct validity was evaluated using multi trait scaling analysis and the extrenal validity was evaluated using correlation between domains in short form 36 (SF 36)with Lupus QoL and with disease activity.Results: Data collection was done to 65 SLE patients between October – November 2015 in RSCM. The test has good external validity SF 36 (r=0.38-0.66, p<0.05) and good construct validity (r >0.4; range: 0.44-0.93). The ICC value in one week >0.7 and Cronbach α was>0.7 in each domain. The correlation between lupus QoL and the disease activity was weak and consistentwith other studies.Conclusion: Lupus QoL questionnaire is valid and reliable to asses the quality of life in SLE patients inIndonesia.Key words: Quality of Life, Systemic Lupus Erythematosus, Lupus QoL, Validity, Reliability
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/60
10.37275/ijr.v8i2.60
Indonesian Journal of Rheumatology; Vol. 8 No. 2 (2016): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v8i2
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/60/58
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/61
2020-05-07T02:47:00Z
ijr:CAS
A Successful Management of 29 year old Female with Left Central Retinal Artery Occlusion due to Manifestation of Primary Antiphospholipid Syndrome
Trianto, Herman Bagus
Wahono, Cesarius Singgih
Dewi, Nadia Artha
Ocular involvement in Anti Phospolipid Syndrome (APS) includes a broad spectrum of manifestations from the anterior and posterior segment or the presence of neuro-ophthalmologic features. A female, 29 years old, came to ER handled by ophthalmology department, with chief complaint left visual loss suddenly since 4 hours before admission. Investigations revealed stable vital signs, VOD 20/20, VOS 1/300, funduscopy showedpale and cherry red spot on left retina, OCT revealed hyperreflective of left inner retinal layer, IgG aCL 51.7 U/mL (50.8 U/mL in OPD 3 months later), and the other examinations were within normal limit. Patient was diagnosed with Central Retinal Artery Occlusion due toPrimary Antiphospolipid syndrome. She was performed occular massage and anterior chamber paracintesis procedure, and given O2 6-8 lpm NRBM, Timolol 0.5% eye drop left eye bid, acetazolamide 250 mg bid, Kalium Slow Release 1 tab qd, Levofloxacine eye drop 1 drop/hour post surgery. After the result of IgM aCL available, we added warfarin 2 mg qd and aspirin 320 mg qd. Patient was discharged 2 days later as visual acuity improved with VOD 20/20 and VOS 0.5/60. Key words: Central retina artery occlusion, primary anti phospolipid syndrome, anti cardiolipin antibody
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/61
10.37275/ijr.v8i2.61
Indonesian Journal of Rheumatology; Vol. 8 No. 2 (2016): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v8i2
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/61/59
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/62
2020-05-07T03:07:08Z
ijr:ORI
Correlation Of Clinical Disease Activity Index And Disease Activity Score-28 in Indonesian Rheumatoid Arthritis Patients
Pasha, Mochamad
Isbagio, Harry
Albar, Zuljasri
Rumende, Cleopas Martin
Background:Clinical Disease Activity Index (CDAI) stands out amongst other methods in measuring disease activity of rheumatoid arthritis (RA) patient. CDAI is considered to be more practical and cost-effective in daily practice because it requires no laboratoryexamination. Previous studies conducted overseas revealed that CDAI has good correlation compared to other scoring index in measuring RA disease activity. However, those studies only included pure RA patients without any comorbidity diseases. Indonesian RA patients have distinct clinical profile, in terms of comorbidity conditions, and genetic predisposition which affect the fenotype of the disease.Objectives: Analyze correlation between CDAI compared to Disease Activity Score 28 CRP (DAS28- CRP) in measuring RA disease activity of RA patients in Indonesia.Methods: We conducted a cross sectional study to RA patients who visited rheumatology clinic at Cipto Mangunkusumo general hospital from April to May 2016. Data collected included history of illness, physical examination, and recent laboratory results. All data were documented in reseach’s form. Both CDAI and DAS28- CRP were measured in each patient by two observers. Correlation analysis between two numeric datas fromCDAI and DAS28-CRP were measured with Spearman’s Rho. Overall performance was analyzed as additional results using R2 index.Result: A total of 119 subjects were included in this study. All subjects were RA patients with comorbidities and were representing quite numbers of Indonesian races characteristic profile. Spearman’s Rho = 0,918 and R2 index =0,831 (83,1%).Conclusion: There is positive correlation result between outcome of CDAI and outcome of DAS28-CRP in assesing disease activity of Indonesian RA patients.Key Word: rheumatoid arthritis, Indonesia, correlation,Clinical Disease Activity Index.
Indonesian Rheumatology Association
2017-06-17
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/62
10.37275/ijr.v9i1.62
Indonesian Journal of Rheumatology; Vol. 9 No. 1 (2017): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v9i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/62/60
Copyright (c) 2018 Indonesian Journal of Rheumatology
https://creativecommons.org/licenses/by/4.0
oai:ojs.data.journalrheumatology.or.id:article/63
2020-05-07T02:46:00Z
ijr:ORI
The Correlation between Body Fat Distribution and Medial Tibiofemoral Joint Space Width in Obese Knee Osteoarthritis Patients
Herikurniawan, Herikurniawan
Isbagio, Harry
Soewondo, Pradana
Diana, Nyimas
Setiati, Siti
Background: Obesity is a major risk factor for knee osteoarthritis. The relationship between obesity and OA may not be simply due to a mechanical factor. Evidences suggest that metabolic factors related to body fat play important roles, but the specific type of fat that contributes to OA is unclear. The objective of this study was to examine the possible correlation between body fat distribution with knee OA.Methods: This study was a cross sectional study of OA patients with obesity visiting the Rheumatology and Geriatric-Internal Medicine clinics at Cipto Mangunkusumo Hospital between January-March 2016. Data was collected by consecutive sampling. Knee OA was diagnosed from clinical and radiologic evaluation based on American College of Rheumatology 1986 criteria. Body fat distribution was measured by bioelectrical impedance analysis (BIA). Conventional radiography of the knee was used to evaluate jointspace narrowing (JSN). The correlation between body fat distribution and joint space width was analyzed by bivariate analysisResult: A total of 56 subjects were recruited, majority were women (73.2%). Median visceral fat was 12% (7.5-16.5), median subcutaneous fat was 30.2% (16.5-37.9), and median visceral to subcutaneous fat ratio was 0,40 (0,26-0,80). The mean medial tibiofemoral joint space width was 2.34 mm (SD 0.78). Bivariate analysis revealed a correlation between visceral fat and medial tibiofemoral joint space width (r: -0,474 p: < 0,001). There is no correlation between subcutaneous fat and medial tibiofemoral joint space width (r: -0,187 p:0,169); and visceral to subcutaneous fat ratio and medialtibiofemoral joint space width (r: -0,225 p: 0,09).Conclusion: Visceral fat is correlated with medial tibiofemoral joint space width (r: -0.474 p: < 0.001). There is no correlation between subcutaneous fat, and visceral to subcutaneous fat ratio, with medial tibiofemoral joint space width.Keywords: Osteoarthritis, obesity, visceral fat, subcutaneous fat, visceral to subcutaneous fat ratio, medial tibiofemoral joint space width
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/63
10.37275/ijr.v9i1.63
Indonesian Journal of Rheumatology; Vol. 9 No. 1 (2017): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v9i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/63/61
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/64
2020-05-07T03:07:43Z
ijr:ORI
Correlation Betweeen Skin Fibrosis Based On Modified Rodnan Skin Score And B-Cell Activating Factor Serum In Systemic Sclerosis
Alfarish, M Arzan
Dewi, Sumartini
Hamijoyo, Laniyati
Wachjudi, Rachmat Gunadi
Background: Progression and expansion of skin fibrosis are the most important characteristics in determining clinical responses and prognosis of Systemic Sclerosis(SSc). Using modified Rodnan skin score (mRSS) can not rapidly detect a slight changes of skin fibrosis in SSc patients. Biomarker assessment is needed to make a more objective, quantitative and rapid evaluation of the changes. Suggested potential useful biomarker isB-cell Activating Factor (BAFF), a positive regulator of B cell survival and maturation process. This study aimed to evaluate correlation between skin fibrosis based on mRSS and BAFF serum in SSc patients.Methods: We used cross sectional methods. Enrolled all patients who met ACR EULAR 2013 criteria for SSc in Rheumatology Clinic Hasan Sadikin Hospital, Bandung, from November 2015 to March 2016. Subjects underwent medical record review, physical examination,mRSS measurement by rheumathologist, and blood tests. Data were analized using Rank-Spearman Correlation.Results: Thirty seven subjects, with mean age 40+10 years old. Subjects consisted of 23(62.2%) limited SSc and 14(37.8%) diffuse SSc. Mean BAFF serum was 1160.2+424.7 pg/mL, no statistical difference were found between limited and diffuse type (p=0.662).Median mRSS results was 16 ranged from 2 to 36.Correlation between mRSS and BAFF serum was not significant (r=0.077; p=0.326).Conclusion: There is no correlation between mRSS and BAFF serum in systemic sclerosis at Hasan Sadikin Hospital.Keywords: mRSS, BAFF, Systemic Sclerosis
Indonesian Rheumatology Association
2017-06-17
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/64
10.37275/ijr.v9i1.64
Indonesian Journal of Rheumatology; Vol. 9 No. 1 (2017): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v9i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/64/62
Copyright (c) 2018 Indonesian Journal of Rheumatology
https://creativecommons.org/licenses/by/4.0
oai:ojs.data.journalrheumatology.or.id:article/65
2020-05-07T02:46:00Z
ijr:ORI
Mucocutaneous Manifestation of Systemic Lupus Erythematosus Patients At Rheumatology Outpatient Clinic In Dr. Hasan Sadikin General Hospital
Veimern, Chin Annsha
Sungkar, Ellyana
Dharmadji, Hartati Purbo
Hamijoyo, Laniyati
Background: Systemic Lupus Erythematosus (SLE) is an autoimmune systemic disease which symptoms induced by Ultraviolet rays exposure. It commonly affects women and causes wide range of symptoms. One of the organs affected is mucocutaneous. Our study aims to determine mucocutaneous manifestations of SLE patients in Rheumatology Outpatient Clinic in Dr.Hasan Sadikin General Hospital, Bandung.Methods: A descriptive study with prospective crosssectional design conducted. Data were obtained by interviewing SLE patients as primary data and accessing medical record as secondary data. Ninety-six SLE patients met the inclusion and exclusion criteria wereincluded.Results: From ninety-six subjects, 94.8% subjects are working indoors. Mucocutaneous manifestation were found in most patients. Based on American College of Rheumatology (ACR) criteria, we found mucocutaneous manifestations, such as: oral ulcers in 67 patients(69.8%); malar rash in 63 patients (65.6%); photosensitivity rash in 51 patients (53.1%), and discoid rash erythematous in 21 patients (21.9%). Specific SLE cutanoeus manifestation based on Gilliam classification were found in our study subjects, such as papulosquamous/ psoriasisform (19.5%) , morbilliform (17.7%), vesicobullous annular SCLE (13.5%), annular SCLE (6.3%), and TEN-like LE (1%). Non-specific LE cutaneousmanifestations based on Gilliam classification were also found in our study subjects, such as oral ulcers (69.8%), photosensitivity rash (53.1%), alopecia (86.5%), Raynaud’s Phenomenon (39.6%), nail abnormalities (24.0%), periungual telangiectasia patients (13.5%), vasculitic lesions (12.5%), thrombophlebitis (44.8%), bullous lesion (5.2%) and erythema multiforme (5.2%).Conclusion: Mucocutaneous manifestations in SLE patients based on ACR criteria found most in this study is oral ulcers. Based on Gilliam classification specific LE cutanoeus manifestation was not found in all SLE patients, while non-specific LE mucocutaneous manifestations mostly found is alopecia. Keywords: American College of Rheumatology (ACR) criteria, Gilliam classification, Mucocutaneous manifestations, Systemic Lupus Erythematosus
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/65
10.37275/ijr.v9i1.65
Indonesian Journal of Rheumatology; Vol. 9 No. 1 (2017): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v9i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/65/63
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/66
2020-05-07T03:08:19Z
ijr:ORI
The Characteristic of Anti dsDNA and Organ System Involved in Systemic Lupus Erythematosus Patient at Hasan Sadikin General Hospital, Bandung
Nadifa, Safira
Achadiyani, Achadiyani
Dharmadji, Hartati Purbo
Hamijoyo, Laniyati
Background : Clinical manifestation of Systemic Lupus Erythematosus (SLE) may be varies in attacking various body tissue and organ system. Anti-dsDNA is the important antibody indetermining diagnosis and prognosis of SLE. This study was conducted to explain the characteristics of antidsDNA and organ system involved in SLE patients.Method:Â We used quantitative descriptive analysis methods. Data were collected from medical records of SLE patients who came to Dr. Hasan Sadikin Bandung General Hospital Rheumatology Clinic from September to November 2016. Using categorical descriptive research equation, we found that total minimum samples were 67 subjects. Data observed included the level of anti-dsDNA antibody and clinical manifestation of organ systeminvolved.Result: From 67 samples, there were 65 females which accounted for 97% of the research subjects. Distribution of organ system involved in our subjects was musculoskeletal (29%), mucocutaneous (27%), hematologic (21%), kidney (15%), neuropsychiatry (4%),lung involvement (4%) and cardiovascular (0%). Organ system involved related with strong positive anti-dsDNA were mucocutaneous (21,6%), hematologic (25%), musculoskeletal (12,5%), kidney (14,3%) and lungs (20%).Conclusion:Â The most frequent organ system involved in SLE patients at our setting was musculoskeletal. The common organ involvement related with strong positive antidsDNA were mucocutaneous, musculoskeletal, and hematologic. Keywords: anti-dsDNA, involvement of organ system, clinical manifestation, systemic lupus erythematosus
Indonesian Rheumatology Association
2017-06-17
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/66
10.37275/ijr.v9i1.66
Indonesian Journal of Rheumatology; Vol. 9 No. 1 (2017): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v9i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/66/64
Copyright (c) 2018 Indonesian Journal of Rheumatology
https://creativecommons.org/licenses/by/4.0
oai:ojs.data.journalrheumatology.or.id:article/67
2020-05-07T02:46:00Z
ijr:ORI
Memory Performance in Patient with Systemic Lupus Erythematosus Using MoCA-Ina in Hasan Sadikin Genneral Hospital Bandung
Anjalia, Safira
Ong, Paulus Anam
Atik, Nur
Hamijoyo, Laniyati
Background: The involvement of neuropsychiatry is reported in 6% to 91% of Systemic Lupus Erythematosus (SLE) patients. It can cause fatal morbidity and mortality. Memory impairment is one of the most common symptoms of neuropsychiatry involvement. This study aims to find out the performance of memory test in SLE patients using Indonesian version of Montreal Cognitive Assessment (MoCA-Ina).Method: This cross sectional study recruited 30 SLE patients. Cognitive abilities and patient’s memory were examined using Indonesian version of Montreal Cognitive Assessment (MoCA-Ina). Cognitive impairment was determined when total MoCA-Ina score was below 26. For memory evaluation, immediate recall or delayed recall impairment was determined when the patient failed in each memory subtests.Results: The mean of total MoCA-Ina score was 24.97 (SD±3.14). Fifty percent of the SLE patients had cognitive impairment, with the domain involved being delayed recall (86.67%), attention (60%), language (56.67%), abstraction (53.33%), and visuo-spatial/ executive function (36.67%). Most patients (86.67%) could completely repeat immediate recall. Whileonly 4 (13.33%) subjects could repeat delayed recall completely without any clue. Of the 26 SLE patients who failed to recall completely, 24 (92.3%) of them succeeded to recall completely after getting clue(s).Conclusion: Memory impairment is the most frequent cognitive impairment in SLE patients, especially in delayed recall. By using the memory subtests of MoCAIna, more than four fifth of patients with SLE was detected having delayed recall memory impairment and almost all of them could recalled completely after getting clue(s). This findings indicated that the finalstep of memory process retrieval in SLE was interrupted while being encoded, but retention pathway were stillintact.Keywords: Systemic Lupus Erythematous, Memory, MoCA-Ina
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/67
10.37275/ijr.v9i1.67
Indonesian Journal of Rheumatology; Vol. 9 No. 1 (2017): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v9i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/67/65
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/68
2020-05-07T03:08:52Z
ijr:CAS
Interstitial lung disease in mixed connective tissue disease
Tendean, Marshell
Nuriawan, Sazkia Aziza
Nugroho, Pringgodigdo
Interstitial lung diseases (ILD) are known as a debilitating pulmonary complications that may be occured in almost all systemic connective tissue diseases (CTD), including mixed connective tissue disease (MCTD). ILD is usually found in more than half of MCTD patients after 2-4years after the diagnosis made. A-47-years-old female initially diagnosed as systemic lupus erythematosus (SLE) developed a severe progressive dyspnea. She has recently diagnosed as MCTD with ILD after 9 months of initial symptoms. She was giving with Cyclophosphamide 500 mg IV pulse dose. However, after 1 months she developed severe pneumonia andpronounced demise due to intractable septic shock. The debilitating course of ILD is commonly seen in most systemic CTD. Therefore, it is important to perform initial screening and prevention. Systemic corticosteroid with or without immunosupressor agent(s) are indicated inILD-MCTD. Patients with progressive diseases will have poor prognosis.Keywords : ILD, MCTD, Corticosteroid
Indonesian Rheumatology Association
2017-06-17
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/68
10.37275/ijr.v9i1.68
Indonesian Journal of Rheumatology; Vol. 9 No. 1 (2017): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v9i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/68/66
Copyright (c) 2018 Indonesian Journal of Rheumatology
https://creativecommons.org/licenses/by/4.0
oai:ojs.data.journalrheumatology.or.id:article/69
2020-05-07T03:02:37Z
ijr:ORI
The Pattern of Joints Involvement in Patients with Rheumatoid Arthritis in Rheumatology Clinic Dr. Hasan Sadikin General Hospital Bandung
Pratama, Muhammad Kevin
Atik, Nur
Hamijoyo, Laniyati
Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease with primary manifestation in the joints. Early management of RA will prevent further joint damage. The joint damages, result of uncontrolled disease activity, will decrease patient’s quality of life.RA should be diagnosed earlier and followed by early treatment initiation, in order to prevent further damages. This study aimed to determine the pattern of joint involvement in RA in order to made earlier diagnosis and treatment initiation.Method: This research was conducted using descriptive study design. Data were obtained using interview of RA patients who coming to Rheumatology Clinic of Dr. Hasan Sadikin General Hospital from August 2016 to October 2016. Collected data included number of joints involvement, duration of therapy, and duration of illness after diagnosed according to the criteria of ACR / EULAR 2010.Result: Ninety-seven RA patients were involved in this study. Subjects were dominantly women (87%), the highest age group was 45-49 years old (17.53%), duration of the disease <5 years (90.72%), and duration of therapy > 3 months (86%). Joint that frequently involved at the time when the diagnosis made was first proximal interphalangeal (49.50%), overall findings during the course of RA was the wrist joint (90.72%).There were different tendency of joint involvement between the gender, knee joints occured in 53,84% male subjects, while PIP joints were accounted for 52,38% infemale subjects.Conclusion: The first PIP was the most common joint involved in RA patients when the diagnosis made. The wrist joint involvement was dominantly found in overall course of RA. Knee joint involvement was majorly found in male RA patients, whereas female RA patients would suffer mostly from PIP joint involvement.Keywords: involvement pattern, joints, rheumatoid arthritis
Indonesian Rheumatology Association
2017-12-17
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/69
10.37275/ijr.v9i2.69
Indonesian Journal of Rheumatology; Vol. 9 No. 2 (2017): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v9i2
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/69/67
Copyright (c) 2018 Indonesian Journal of Rheumatology
https://creativecommons.org/licenses/by/4.0
oai:ojs.data.journalrheumatology.or.id:article/70
2020-05-07T03:03:14Z
ijr:ORI
Correlation Between Serum Procollagen Type 1 N-Terminal Propeptide Level With Modified Rodnan Skin Score In Systemic Sclerosis Patients.
Vincent, Vincent
Dewi, Sumartini
Wachjudi, Rachmat Gunadi
Introduction: Systemic Sclerosis (SSc) is a chronic autoimmune disease, characterized by vasculopathy, specific autoimmune, and fibrosis. Assesment of skin fibrosis by modified Rodnan Skin Score (mRSS) can not detect the minimal changes of skin fibrosis within lessthan 3 months. A biomarker is needed to assess the minimal changes of skin fibrosis progressivity with a more objective, quantitative, and rapid way. Procollagen type-1 N-Terminal Propeptide (P1NP), a degradation product of collagen type-1, may become a potential biomarker for skin fibrosis. This study aims to evaluate the correlation between skin fibrosis by mRSS with P1NP serum in systemic sclerosis.Methods: This was a cross-sectional study performed among systemic sclerosis patients at Rheumatology outpatient clinic, Dr.Hasan Sadikin Hospital Bandung, from May 2016 to July 2016. Skin fibrosis was measured by mRSS. P1NP level was determined by ELISA. Data were analyzed using Rank-Spearman Correlation.Result: There were thirty-seven subjects, with mean age 37 (SD ±7) years old. Most of subjects were female (91.9%). Subjects consisted of 23 (62.2%) limited SSc and 14 (37.8%) diffuse SSc. Six subjects (16.2%) were DMARD naïve. We found median (range) P1NP serum was 43.85 (9.81-127.90) ng/dL, while the median of MRSS was 14 (3-36). There is a moderate correlation between MRSS and P1NP serum (r=0.443, p=0.003)Conclusion: There was a significant correlation between mRSS and P1NP serum in systemic sclerosis patient at Dr. Hasan Sadikin Hospital Bandung.Keywords: systemic sclerosis, P1NP, modified rodnan skin score
Indonesian Rheumatology Association
2017-12-17
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/70
10.37275/ijr.v9i2.70
Indonesian Journal of Rheumatology; Vol. 9 No. 2 (2017): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v9i2
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/70/68
Copyright (c) 2018 Indonesian Journal of Rheumatology
https://creativecommons.org/licenses/by/4.0
oai:ojs.data.journalrheumatology.or.id:article/71
2020-05-07T03:03:46Z
ijr:ORI
Most Frequent Musculoskeletal Manifestation of Systemic Lupus Erythematosus Patients in Dr. Hasan Sadikin General Hospital Bandung
Sutrisno, Rahadian Nugi
Rahmadi, Andri Reza
Novita, Nita
Hamijoyo, Laniyati
Background: Systemic Lupus Erythematosus (SLE) is an autoimmune disease with wide range of clinical symptoms. The patients frequently complain musculoskeletal involvement during the active state of the disease. Musculoskeletal manifestation in SLE patients is an important sign in making early diagnosis and monitoring treatment response. This study aims to determine the presentation of musculoskeletal involvement of SLE patients in Dr. Hasan Sadikin General Hospital Bandung.Methods: a descriptive cross-sectional quantitative study done by interviewing SLE patients concerning musculoskeletal manifestation as the primary data and tracking their medical record as the secondary data. Study was conducted between September to November 2016 in Rheumatology Clinic Dr. Hasan Sadikin General Hospital Bandung.Result: Ninety-seven SLE patients, 91 females (93,81%) and 6 males (6,19%), were enrolled in this study with mean age 35.12 (±10.91) years. The three highest proportions of muskuloskeltal manifestations were arthritis of the knee (84,5%), myalgia of upper back(40,2%), and muscle weakness (15,5%). We did not find any Jaccoud’s Arthropathy (JA) and tendinitis manifestation. Osteoporosis were occured in 4 patients (4,12%), whereas gout arthritis, spondytlitis, osteoarthritis, rotator cuff syndrome, and rhupus wereonly occured in one patient (1,03%), respectively.Conclusion: The common musculoskeletal manifestation in SLE patients were arthritis of knee, myalgia of upper back, and muscle weakness. Only small portion of patients suffered from osteoporosis, gout arthritis, spondytlitis, osteoarthritis, rotator cuff syndrome, and rhupus.Keyword: musculoskeletal manifestation, musculoskletal involment, SLE
Indonesian Rheumatology Association
2017-12-17
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/71
10.37275/ijr.v9i2.71
Indonesian Journal of Rheumatology; Vol. 9 No. 2 (2017): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v9i2
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/71/69
Copyright (c) 2018 Indonesian Journal of Rheumatology
https://creativecommons.org/licenses/by/4.0
oai:ojs.data.journalrheumatology.or.id:article/72
2020-05-07T02:45:10Z
ijr:ORI
Neuropsychiatric Manifestation Screening among Systemic Lupus Erythematosus Patients in Hasan Sadikin General Hospital Bandung
Putra, Septian Dwi
Ardisasmita, Mulya Nurmansyah
Hamijoyo, Laniyati
Background: Systemic Lupus Erythematosus (SLE) is an autoimmune diseases caused by deposition of immune complex with the involvement of various organ system and certain autoantibodies production. One of the most significant manifestation is neuropsychiatricsymptoms, known as NPSLE (Neuropsychiatric Systemic Lupus Erythematosus). This study aims to portray the distribution of neuropsychiatric manifestation of SLE patients using a screening method in Hasan Sadikin General Hospital.Method: An observative, descriptive categoric study, with consecutive sampling were done. Data were collected by spreading the questionnaire to subjects diagnosed as SLE who visiting Hasan Sadikin General Hospital during August-October 2016 and by tracingtheir medical records. Data analyzed included age, sex, education background, duration of lupus, diagnosis criteria, ongoing therapy, and neuropsychiatric manifestation.Result: Samples volunteered in this study were 97 patients. Of them 94 patients (96.9%) were women and 47 patients (48.5%) were senior high school graduated. Most common diagnosis criteria found was positive ANA test (91.8%). Most necessary ongoing therapygiven was methylprednisolone (96.9%). Common neuropsychiatric manifestations were mood disorders (73,2%), headache (57,7%), and mononeuropathy (51,5%).Conclusion: The common psychiatric, central nervous, and peripheral nervous manifestations were mood disorder, headache, and mononeuropathy, respectively.Keywords: Neuropsychiatry, NPSLE Screening,Systhemic Lupus Erythematosus
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/72
10.37275/ijr.v9i2.72
Indonesian Journal of Rheumatology; Vol. 9 No. 2 (2017): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v9i2
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/72/70
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/73
2020-05-07T02:45:10Z
ijr:ORI
Overview of Anemia among Systemic Lupus Erythematosus Patients in Reproductive Age Women based on Reticulocyte Hemoglobin Equivalent (RET-He) Level and Reticulocyte Count
Modjaningrat, Ismiana Fatimah
Oehadian, Amaylia
Ghozali, Mohammad
Hamijoyo, Laniyati
Background: Anemia is a common manifestation found among patients with Systemic Lupus Erythematosus (SLE). It may be caused by iron-deficiency, autoimmune hemolytic, and chronic inflammation. Each anemia has different therapy approachments. Without adequatemanagement, anemia may lead to poor prognosis. By identifying the etiology of anemia, appropriate management could be conducted. Reticulocyte Hemoglobin Equivalent (RET-He) and reticulocyte count test may distinguish anemia based on its etiology. This study aimed to give scientific portrayed of the proportion of anemia based on its etiology among patients with SLE using RET-He and reticulocyte count.Method: This study involved women diagnosed with SLE underwent outpatient treatment in Rheumatology Clinic, Dr. Hasan Sadikin General Hospital during SeptemberOctober 2016. Data were collected from blood exam using 35-parameters hematology Sysmex by calculating levels of hemoglobin, RET-He, and reticulocyte count.Results: Seventy four female patients were volunteered as subject in this study with median of age was 29.5 (16-70) years old. Thirty four (46%) of 74 subjects weresuffering from anemia and 12 (35%) of them were between 25-34 years old. Proportion of iron-deficiency anemia, autoimmune hemolytic anemia, and chronic inflammatory anemia were 14 ( 41%), 13 (38%), and 7 (21%), respectively.Conclusion: Based on hemoglobin, RET-He, and reticulocyte count, iron-deficiency anemia is the most common anemia among patients with SLE in repoductive age.Keyword: Age, Anemia, Reticulocyte, RET-He, Systemic Lupus Erythematosus (SLE)
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/73
10.37275/ijr.v9i2.73
Indonesian Journal of Rheumatology; Vol. 9 No. 2 (2017): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v9i2
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/73/71
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/74
2020-05-07T03:05:14Z
ijr:ORI
Outcome of Pregnancy in Patients with Systemic Lupus Erythematosus
Yue, Erica Kwan
Rita, Coriejati
Hamijoyo, Laniyati
Background: Systemic lupus erythematosus (SLE) is an autoimmune disease which involves many different organ systems and immunological abnormalities. SLE mainly affects females in their reproductive age. This study aimed to describe the fetal outcome, neonatalcomplications, maternal outcome, and obstetrics complication in patients diagnosed with SLE, in order to help the physicians to reduce the fetal loss, improve maternal morbidity, and reduce neonatal or maternal deaths.Method: This research was conducted using descriptive quantitative design. Data were obtained from direct interview noted in a report form and medical records. Subjects were SLE patients who came to Rheumatology Outpatient clinic, Dr. Hasan Sadikin General Hospital, Bandung from September 2016 to November 2016; and fulfilled the inclusion and exclusion criteria. The minimal required sample was 96 subjects.Results: Due to time limitation, only 53 pregnancies from 40 females were managed to be recorded. The median age when being diagnosis of the subjects was 24 (14 - 41) years old. The fetal outcomes showed 64.2% live births, 18.9% spontaneous abortions, 9.4% intrauterine death, 1.8% intrauterine growth retardation, and 9.1% neonatal deaths. Neonatal complications included premature delivery, low birth weight, and growth retardation. Maternal complications during pregnancy included rash, pregnancy-inducedhypertension, arthritis, anemia, and thrombocytopenia. Furthermore, obstetric complications included 13.2% pre-eclampsia, 13.2% placenta previa, and 1.8% stroke.There were 2 cases (3.8%) of maternal death happened during the delivery.Conclusion: The most frequent maternal complications during pregnancy were arthritis and rash. Pre-eclampsia and placenta previa were the most frequent obstetric complications which experienced by the pregnant SLE patients. Exclude the live births, the most frequent fetal outcome was spontaneous abortion. The most frequent neonatal complications were preterm delivery and low birth weight.Keywords: pregnancy, systemic lupus erythematosus, fetal outcomes, maternal outcomes
Indonesian Rheumatology Association
2017-12-17
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/74
10.37275/ijr.v9i2.74
Indonesian Journal of Rheumatology; Vol. 9 No. 2 (2017): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v9i2
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/74/72
Copyright (c) 2018 Indonesian Journal of Rheumatology
https://creativecommons.org/licenses/by/4.0
oai:ojs.data.journalrheumatology.or.id:article/75
2020-05-07T03:04:28Z
ijr:CAS
Osteomalacia Induced by Renal Tubular Acidosis Type 1
Sihombing, Steven Sutanto
Ariane, Anna
Wibowo, RM Suryo Anggoro Kusumo
Setyohadi, Bambang
Renal Tubular Acidosis, a group of disorders characterized by defective renal acid-base regulation, can impair mineralization of bone matrix in adults known as osteomalacia. RTA is classified into 3 major forms, such as proximal RTA or type 2; distal RTA or type 1; and hyperkalemic RTA or type 4. Among all type of RTA, proximal RTA or type 2 is known have association with Fanconi syndrome and bone involvement. However, distal RTA or type 1 can also cause osteomalacia. Hereby we report a case of 22 years old Asian woman who wasfirstly diagnosed with distal type RTA several years ago then started developing bone involvement recently. She was complaining with low back pain due to fracture on left medial side of inferior pubic ramus and endplate fracture on right side superior L4 and BMD examination showed low mineral density. She was diagnosed with osteomalacia induced by distal type RTA due to the loss of calcium salts from bone and hypophosphatemia.Keywords: Osteomalacia; Renal Tubular Acidosis; Hypokalemia; Hypophosphatemia
Indonesian Rheumatology Association
2017-12-17
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/75
10.37275/ijr.v9i2.75
Indonesian Journal of Rheumatology; Vol. 9 No. 2 (2017): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v9i2
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/75/73
Copyright (c) 2018 Indonesian Journal of Rheumatology
https://creativecommons.org/licenses/by/4.0
oai:ojs.data.journalrheumatology.or.id:article/76
2020-05-07T02:58:11Z
ijr:REV
Diagnosis and management of osteomyelitis
Gunawan, Gunawan
Setiyohadi, Bambang
Osteomyelitis is an infection of the bone that causes bone destruction and formation of new bone as the result of the infl ammatory process. Proper diagnosis in osteomyelitis is important since it determines the decision-making in the management of the disease: whether to perform aggressive treatments or administration of long-term antibiotic treatment. Imaging techniques play an important role in the diagnosis of osteomyelitis, but their results should be interpreted with care as they have a wide range of sensitivity and specifi city. A combination of imagingtechniques could improve their sensitivity and specifi city. Conventional radiography is an affordable and widely available technique, and has been proven to be useful in diagnosing and excluding the differential diagnosesof osteomyelitis. Surgical intervention to remove necrotic tissues and administration of antibiotics to eradicate pathogens are necessary in the anagementof osteomyelitis. Several antibiotics such as quinolones,rifampin, and clindamycin have been proven to havegood penetration into bone.
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/76
10.37275/ijr.v2i3.76
Indonesian Journal of Rheumatology; Vol. 2 No. 2 (2010): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v2i3
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/76/74
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/77
2020-05-07T02:58:11Z
ijr:REV
Tuberculous arthritis: an overview
Hamijoyo, Laniyati
Tuberculous arthritis is a part of tuberculosis infection. Although the number of this disease is very small compared to the other causes of muskuloskeletal infection, it can cause joint damage and eventually disability to the patient. Tuberculous arthritis should always be considered as one of the differential diagnosis in cases with insidiously developed monoarticulararthritis of the large weight-bearing joints, especially in developing countries where there is a high prevalence of tuberculosis. Early recognition and treatment with antituberculosis drugs provide better outcome for the patient; however, surgery due to unresponsiveness to medical treatment or presence of large abscess,arthroplasty, and arthrodesis may be necessary.
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/77
10.37275/ijr.v2i3.77
Indonesian Journal of Rheumatology; Vol. 2 No. 2 (2010): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v2i3
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/77/75
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/78
2020-05-07T02:58:11Z
ijr:ORI
Role of diacerein in pain intensity and functional status in patients with knee osteoarthritis
Kasjmir, Yoga I
Imelda, F
Erawati, L
Background: Infl ammation is an important mechanism in the pathogenesis of osteoarthritis (OA). Proinfl ammatory mediators, especially interleukin-1β (IL-1β), play a signifi cant role in the occurrence of joint infl ammation, which lead to pain and limitation of daily activities. As an anti–IL-1β, diacerein is therefore have potency to reduce pain and improve functional status of OA patients.Objective: To evaluate the role of diacerein in pain intensity and functional status of knee OA patients. Methods: This is a pre-post study without control group using consecutive sampling conducted at rheumatology outpatient clinic at the Cipto Mangunkusumo General Hospital, Jakarta from January until May 2006. At the fi rst visit, all patients underwentassessment of pain intensity (using visual analog scale (VAS)) and functional status (Lequesne algofunctional index) to obtain baseline data. We also performed kneeradiograph examination to evaluate joint damage basedon the Kellgren-Lawrence classifi cation. Measurement of IL-1β level in synovial fl uid was performed using enzyme-linked immunosorbent assay, with a minimum detectable value of 3.9 pg/mL. Diacerein wasadministered with a dose of 50 mg, given orally twice a day for 2 months. Follow-ups were done in the fi rst, second, and eighth week after the administration of diacerein. In the eighth week we repeated the measurement of IL-1β level.Results: Thirty three patients were enrolled in this study, most (78.8%) of them were female. The majority (81.8%) belong to the 50- to 70-year-old age group. More than half of the patients (54.5%) had detectable IL-1β level. The median baseline VAS score was 65.00 (range 25–100) while the median baseline Lequesne score was 11.00 (range 1.5–21.0). The statistical analysis showed a signifi cant decrease in VAS at the fi rst (p = 0.000), second(p = 0.000), and eighth week (p = 0.000). Lequesne index score was also decrease signifi cantly at the fi rst (p =0.000), second (p = 0.000), and eighth week (p = 0.000)of treatment. We found no signifi cant correlation of IL-1β level with VAS and Lequesne algofunctional index scores.Conclusions: Among the patients in this study, there were signifi cant decrease in pain intensity and disabilityafter the administration of diacerein.
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/78
10.37275/ijr.v2i3.78
Indonesian Journal of Rheumatology; Vol. 2 No. 2 (2010): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v2i3
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/78/76
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/79
2020-05-07T02:58:11Z
ijr:ORI
Reliability and validity of European Quality of Life 5 Dimension (EQ-5D) for measuring health-related quality of life in knee osteoarthritis patients at Cipto Mangunkusumo General Hospital
Pramono, A
Sumariyono, Sumariyono
Isbagio, Harry
Background: Quality of life is very important to knee osteoarthritis (OA) patients. The term quality of life denotes one that is health-related. One of the questionnaires most frequently used to measure the quality of life is the European Quality of Life 5-Dimension (EQ-5D) questionnaire. At Cipto Mangunkusumo General Hospital, until today there has not been any instrument for measuring the health-related quality of life in knee OA patients that has been tested for its reliability and validity.Objective: To prove the reliability and validity of EQ-5D as a measurement tool in determining the healthrelated quality of life in knee OA patients at Cipto Mangunkusumo General Hospital.Methods: This is a validity study in which all patients were asked to complete both the EQ-5D form and 36- item short form (SF-36) on their fi rst visit. They were subsequently asked again to complete only the EQ-5Dform one week after their fi rst visit.Results: Data were obtained from 86 respondents.The value of the intraclass correlation coeffi cient of each EQ-5D dimension, EQ-5D index, and visual analogue scale (VAS) was excellent (>0.75). Cronbach’s α value for internal consistency reliability in this study was0.6772 (<0.7). The external validity of EQ-5D compared to SF-36 was analyzed with the Pearson’s correlation test and revealed a signifi cant correlation (p<0.01) of all EQ-5D dimensions, EQ-5D index, and EQ-5D VAS with total score of SF-36 except for the dimensions of self-care, pain, and anxiety/depression. The construct validity of EQ-5D showed that all of the dimensions were signifi cantly correlated with the EQ-5D index (p<0.01) except for self-care dimension.Conclusion: EQ-5D is a valid and reliable measurement tool. It is thus recommended for measuring the healthrelated quality of life in knee OA patients at CiptoMangunkusumo General Hospital.
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/79
10.37275/ijr.v2i3.79
Indonesian Journal of Rheumatology; Vol. 2 No. 2 (2010): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v2i3
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/79/77
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/80
2020-05-07T02:58:11Z
ijr:ORI
Correlation of interleukin-17 with disease activity and hand joint damage in patients with rheumatoid arthritis
Ongkowijaya, Jeffrey Arthur
Setiyohadi, Bambang
Manuaba, Ida Ayu Ratih Wulansari
Kasjmir, Yoga I
Background: Rheumatoid arthritis (RA) is a disease involving various types of cytokines. One of them is interleukin-17 (IL-17), which is known to have a pleiotropic effect on various of cells and is thought to be a cytokine effector contributing to the pathogeniccondition in RA.Methods: The study was conducted on 46 RA patients at rheumatology clinic at the Cipto Mangunkusumo General Hospital who were diagnosed based on the 1987 American College of Rheumatology criteria. Sample selection was done using consecutive sampling. Tests on patients were conducted to collect data needed to obtain the scores for 28-joint Disease Activity Score (DAS28), global health visual analogue scale, swollen joint count, tender joint count, sedimentation rate, Sharp score (radiograph of both hands), and the IL-17 level.The correlation between IL-17 level and DAS28 was calculated using the Pearson’s correlation test while the correlation between IL-17 level and Sharp score was calculated using the Spearman’s test.Results: The majority of patients (87%) were women. The largest percentage was in the 51- to 60-year-old group (39.1%). Most patients (43.1%) had moderate disease activity. There were 27 patients (58.69%) with positive rheumatoid factor. The mean IL-17 level was17.28 pg/mL with a standard deviation of 11.43 pg/mL. There was no correlation of IL-17 level with disease activity (p = 0.446, r = 0.021) and Sharp score (p = 0.304, r = 0.077) in subjects of this study.Conclusion: There was no signifi cant correlation of IL-17 with disease activity and joint damage.
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/80
10.37275/ijr.v2i3.80
Indonesian Journal of Rheumatology; Vol. 2 No. 2 (2010): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v2i3
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/80/78
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/81
2020-05-07T02:58:11Z
ijr:ORI
Prevalence of anti–C-reactive protein autoantibody and its correlation with disease activity in systemic lupus erythematosus patients at Cipto Mangunkusumo General Hospital
Lusiani, Lusiani
Setiyohadi, Bambang
Sukmana, N
Abdullah, M
Background: Systemic lupus erythematosus (SLE) is a complex autoimmune disease with various underlying mechanisms characterized by autoantibody overproduction. It has been known that mortality and morbidity of SLE was higher in Asian patients compared with white patients. Several studies had showed that C-reactive protein (CRP) has the ability to suspend the progression of SLE through regulatory and clearance pathway, and low level of CRP and high level of anti-CRP antibody has been detected in SLE patients. A question raise whether mortality and morbidity in Asian SLE patients are associated with anti-CRP antibody.Objective: To study the prevalence of anti-CRP antibody and its relationship with disease activity in SLE patients at Cipto Mangunkusumo General Hospital,Jakarta.Methods: This is a cross-sectional study conducted at Cipto Mangunkusumo General Hospital from December 2009 until May 2010. Subjects were SLE patients whowere diagnosed based on the 1982 American College of Rheumatology criteria. Disease activity was measured using the Mexican SLE Disease Activity Index scoringsystem. Anti-CRP antibody assay was performed using the Western blot analysis. Correlation between the presence of anti-CRP antibody and disease activitywas evaluated using the T-test and multivariate logistic regression analysis.Result: Forty SLE patients with a mean age of 31.65 (SD 8.84) were enrolled in the study, 33 of which (82.5%) had positive autoantibody to CRP pentamer. The anti-CRP antibody was signifi cantly correlated (p = 0.024) with disease activity. Conclusions: There was a relatively large proportion of patients with positive anti-CRP antibody among SLE patients in Cipto Mangunkusumo General Hospital. Therewas also a signifi cant correlation between anti-CRP antibody and the disease activity.
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/81
10.37275/ijr.v2i3.81
Indonesian Journal of Rheumatology; Vol. 2 No. 2 (2010): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v2i3
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/81/79
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/82
2020-05-07T02:58:11Z
ijr:CAS
Invasive aspergillosis in a systemic lupus erythematosus patient
Setiyohadi, Bambang
Azizi, M S
Yuliani, Ika Wulan
Sukmana, N
Suhendro, Suhendro
Simadibrata, M
Rumende, C Matin
Sulaiman, A S
Wahyuningsih, R
Lisnawati, Lisnawati
Yudharto, M A
Anggraini, N
Oktaviana, F
Sandra, R
Systemic lupus erythematosus (SLE) is an autoimmune disease with a broad clinicalmanifestation characterized by production of antibodies against cellular nuclear components. The prevalence of SLE among many countries is variable, ranging from 2.9 to 400 per 100,000. In Cipto Mangunkusumo General Hospital, the incidence of SLE between 1990 and 1998 is 37.3 per 10,000 hospitalization.1 Patients with autoimmune disease have at least twofold risk of acquiring infections compared with healthy individuals. This may be due to the immunosuppresant therapy but could also caused by the primary immune dysregulation that was the basis for the pathogenesis of their disease, or other autoimmune disease manifestations such as lymphopenia.2 Infection is the main factor increasing the mortality and morbidity of SLE patients. A study in New York conducted between 1966 and 1976 involving 223 SLE patients reported 150 cases of infection, of which 23 were opportunistic infection: 12 were candidiasis while 11 others were deep fungal infection. The use of corticosteroids in SLE is the main factor that predispose patients to infection, particularly fungal infection.3 Aspergillosis is the term used to denote all disease caused by any one of the pathogenic and allergenic species of Aspergillus. The annual incidence of aspergillosis in the United States is reported to be 1–2 per 100,000.4 Aspergillus fumigatus is the cause of most cases of invasive aspergillosis, almost all cases of chronic aspergillosis, and most allergic syndromes. The mortality rate of invasive aspergillosis is 50% when properly diagnosed and treated; otherwise it could be as high as 100%
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/82
10.37275/ijr.v2i3.82
Indonesian Journal of Rheumatology; Vol. 2 No. 2 (2010): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v2i3
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/82/80
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/83
2020-05-07T02:58:11Z
ijr:CAS
Tuberculous osteomyelitis in an immunocompetent patient with miliary tuberculosis
Gunawan, Gunawan
Harahap, A
Setiyohadi, Bambang
Rumende, Cleopas Martin
Osteomyelitis is an infection of the bone, which may be caused by direct pathogen inoculation following trauma of surgery, contiguous spread from adjacent soft tissue or joint, or hematogenous spread from a focus of infection. Hematogenous osteomyelitis accounts for 20% of all cases of osteomyelitis.1 This type of osteomyelitis most often affect the long bones and vertebrae, although it could also affect other sites such as pelvic bones or clavicle.1 Mycobacterium tuberculosis is one of the causes of hematogenous osteomyelitis,comprising of 10 to 35 percent of extrapulmonary tuberculosis, or 2% of all tuberculosis cases.2,3 Joint involvement, when occur, is usually monoarticular, and mainly affect the weight-bearing joints such as hip or knee. Polyarticular cases occur in 10– 15% of extrapulmonary tuberculosis cases in developing countries.4 Tuberculous osteomyelitiscases are reported to be decreasing in number, probably because of earlier diagnosis and promptmanagement. In this article we report a case oftuberculous osteomyelitis in a patient with miliary tuberculosis
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/83
10.37275/ijr.v2i3.83
Indonesian Journal of Rheumatology; Vol. 2 No. 2 (2010): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v2i3
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/83/81
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/84
2020-05-07T02:53:11Z
ijr:ORI
Prevalence and factors associated with vitamin D deficiency in systemic lupus erythematosus patients
Pangestu, Y
Setiati, S
Setiyohadi, Bambang
Sukmana, N
Background: In addition to the calcium-phosphorus metabolism, vitamin D might also play a role in the immune system. Studies have showed lower levels of vitamin D among SLE patients compared with controls. Researches regarding vitamin D in SLE patients have only been conducted in four seasons’ countries (Caucasians subjects in a large part) , but no data has been available in tropical countries, particularly Indonesia. The presence of VDR gene polymorphism in different populations will affect the role of vitamin D in the immune system. Objectives: To determine the prevalence of vitamin D deficiency and identify its risk factors such as lack of sunlight exposure, sunscreen usage, long-term corticosteroid therapy, disease activity, insufficient vitamin D supplementation, and obesity in SLE patientswith vitamin D deficiency.Methods: A cross-sectional study was conducted on SLE patients who were under treatment at Cipto Mangunkusumo General Hospital or members of Indonesian Lupus Foundation. Then those patients completed questionnaires and their 25(OH)D serum levels were measured. The cut-off value of 25(OH) D levels for vitamin D inadequacy is 75 nmol/L, which then grouped into vitamin D insufficiency (25(OH)D 25 - <75 nmol/L) and vitamin D deficiency (25(OH)D <25 nmol/L). SLE activity was assessed with MEX-SLEDAI.Results: During May-June 2008, 80 SLE patients were enrolled with 96.3% female subjects, median age of 26 years (range 17-56 years), 66.3% non-obese, 93.8% using steroid, 62.5% with active disease, and 63.8%have adequate sun exposure. In addition, 81.5% didnot use sunscreen and 83.8% did not take vitamin D supplementation. All patients had vitamin D inadequacy with 41.2% in insufficiency level and the other 58.8% in deficiency level. The median of 25 (OH)D levels were 21.85 nmol/L (range 11.5-57.7 nmol/L). It also has been found that vitamin D deficiency occurred more in subjects who were obese, used sunscreens, had lower exposure to sunlight, in a long-term high-dose steroid therapy, had active SLE disease, and had no vitamin D supplements.Conclusions: All SLE patients had vitamin D inadequacy. Vitamin D deficiency occurred more in subjects who were obese, used sunscreens, had lower exposure to sunlight, in a long-term high-dose steroid therapy, had active SLE disease, and had no vitamin Dsupplements.
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/84
10.37275/ijr.v4i1.84
Indonesian Journal of Rheumatology; Vol. 4 No. 1 (2013): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v4i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/84/82
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/85
2020-05-07T02:53:11Z
ijr:ORI
The effect of disease duration on the incidence of peripheral arterial disease in young adults with systemic lupus erythematosus
Merlyn, M
Setyohadi, Bambang
Soebardi, S
Harimurti, K
Background: Peripheral arterial disease is a chronic complication that affects morbidity and mortality in SLE patient. However, there were only a few of researches studying the relationship of disease duration and peripheral arterial disease event overseas and it hasnever been studied in Indonesia.Objectives: To obtain information about the increased event of peripheral arterial disease in women of 40 years old or younger with SLE’s duration of five years or longer compared with less than five years.Methods: This was a case control study conducted between June - August 2012 at Cipto Mangunkusumo hospital, Jakarta. Subjects were women of 40 years old or younger with SLE who visited Rheumatolgy and Allergy-Immunlogy outpatient clinic. They were assignedto case and control groups and traced retrospectively using interview and medical record. The relationship between disease duration and peripheral arterial disease was estimated using OR and the role of confounding factors was analysed using logistic regression one byone, resulted in fully adjusted OR.Results: A total of 90 subjects were recruited, 18 subjects in case group and 72 subjects in control group.Traditional risk factors were similiar in both groups. In multivariat analysis, there was a relationship between disease duration 5 years or longer and peripheral arterialdisease with fully adjusted OR 1,9 (95%CI 0,575-6,543). Older age and steroid therapy were the confounding factors.Conclusion: There was an increased event of peripheral arterial disease in women of 40 years old or younger with SLE’s duration five years or longer compared withsubjects having the disease duration less than five years, but this increase was not statistically significant.Keywords: Peripheral arterial disease, lupus erythematosus systemic, disease duration
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/85
10.37275/ijr.v4i1.85
Indonesian Journal of Rheumatology; Vol. 4 No. 1 (2013): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v4i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/85/83
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/86
2020-05-07T02:53:11Z
ijr:ORI
A survey on the clinical diagnosis and management of gout among general practitioners in Bandung
Hidayat, II
Hamijoyo, L
Moeliono, M A
Backgrounds: The global prevalence of gout and hyperuricemia is increasing in recent years. As the most visited health care service, it is thus become more important that general practitioners have proper approach in the diagnosis and treatment of patients withgout, in order to prevent complications of the disease as well as adverse effects of inappropriate and improper use of medications.Objective: To determine whether the practice of general practitioners on the clinical diagnosis and management of gout in Bandung have been appropriate, with the implementation of evidence-based medicine.Methods: This was a descriptive cross-sectional qualitative study, done by survey using a questionnaire, conducted among general practitioners who attended medical symposia in Bandung from January to March 2011.Result: There were 173 respondents participating in this survey. Median age of respondents was 33 years (range 23–73 years), with median duration of practice of 7 years (range 0–45 years). The largest proportion of the respondents often suggested measurement of serum uric acid to patients with any joint pain (45.7%), did not recommend synovial fluid examination to patients suspected of having gout (80.8%), usually prescribedallopurinol to patients with asymptomatic hyperuricemia (52.6%), initiated allopurinol therapy during acute gout attack (35.8%), discontinued allopurinol therapy when serum uric acid normalizes (61.8%), and only very rarely gave prophylactic treatment to patients who started allopurinol therapy (43.4%).Conclusion: The majority of general practitioners had not applied or aware about evidence-based medicine in the diagnosis and management of gouty arthritis.
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/86
10.37275/ijr.v4i1.86
Indonesian Journal of Rheumatology; Vol. 4 No. 1 (2013): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v4i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/86/84
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/87
2020-05-07T02:53:11Z
ijr:ORI
Correlation of serum level of interleukin-6 and disease activity with bone-resorption activity in premenopausal rheumatoid arthritis patients
Akil, Natsir
Isbagio, H
Sumariyono, Sumariyono
Background: Rheumatoid arthritis (RA) is a chronic, systemic disease characterized by inflammation and cellular proliferation in the synovial lining of joints that can ultimately result in cartilage and bone destruction.Patients with RA are at increased risk of osteoporotic fractures in both axial and appendicular bones. Several cytokines are involved in the pathogenesis of osteoporotic RA patients, including tumor necrosis factor α, interleukin (IL)-1, IL-6, and IL-17. Among these cytokines, IL-6 has a pivotal role in the pathogenesis of increased bone resorption in postmenopausal RA patients. There are currently scarce data concerning this process in premenopausal RA patients.Objective: To determine the correlation of serum level IL-6 and disease activity with bone-resorption activity in premenopausal RA patients. Methods: This is a cross-sectional study with consecutive sampling method conducted at the Division of Rheumatology, Cipto Mangunkusumo General Hospital from June until August 2010. Bone-resorption activity was quantified using serum C-terminal crosslinking telopeptide of type I collagen (CTx-I) level, while disease activity was assessed using the 28-joint disease activity (DAS28) score. Statistical analysis was performed to investigate the correlation of serum IL-6 level and disease activity with serum CTx-I level.Results: There were 38 patients enrolled in this study. Mean serum level of IL-6 was 10.99 pg/mL (SD 16.06). Mean serum level of CTx-I was 405.37 pg/mL (SD 199.32). There was no significant correlation (p = 0.252) between serum IL-6 level with serum CTx-I level;however, a significant correlation existed (r = 0.389, p = 0.033) among seropositive patients. There was no significant correlation (p = 0.257) between the DAS28score with serum CTx-I level.Conclusion: There were no significant correlation either of serum IL-6 level or disease activity with serum CTx-I level among patients in this study
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/87
10.37275/ijr.v4i1.87
Indonesian Journal of Rheumatology; Vol. 4 No. 1 (2013): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v4i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/87/85
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/88
2020-05-07T02:53:11Z
ijr:ORI
The characteristics of hemophilic patients with decreased bone density in Cipto Mangunkusumo Hospital Jakarta
Anggoro, S
Setyohadi, B
Sukrisman, L
Setiati, S
Background: Hemophilia can cause musculoskeletal complications and decreased bone density is one of those complications. The profile of hemophilic patients with decreased bone density in Indonesia is still unknown.Objective: To estimate the proportion of decreased bone density hemophilia and to learn the characteristics of hemophilic patients with decreased bone density.Methods: This is a cross-sectional study done in June - November 2012. Subjects were adult hemophilic patients from 19-50 years old in Hematology- Oncology outpatient clinic Cipto Mangunkusumo Hospital. Estimated variables were bone density mass, age, bodymass index, physical activity, arthropathy, substitution therapy, HIV, and HCV infection.Result: 63 subjects were included in the study with median age of 26 years old. The proportion of decreased bone density in hemophilia was 6.3%. Subjects with decreased bone density were younger (19 years old vs 26 years old), have lower BMI (18,6 + 2,8 kg/m2 vs 21,5 + 3,8 kg/m2), used more substitution therapy (4047 IU/month vs 2000 IU/month), and have better clinical arthropathy score. HCV infection happened on 25% subjects with decreased bone density while HIV was on 1.6% of subjects.Conclusion: Decreased bone density was found in 6.3% of subjects with hemophilia. They were younger, have lower BMI, better joint score, lower infection caused by transfusion, and more bleeding compared with subjects with normal bone density.
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/88
10.37275/ijr.v4i1.88
Indonesian Journal of Rheumatology; Vol. 4 No. 1 (2013): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v4i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/88/86
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/89
2020-05-07T02:53:11Z
ijr:CAS
Systemic sclerosis and hyperthyroidism in pregnancy
Awalia, Awalia
Yuliasih, Yuliasih
Soeroso, Joewono
Systemic sclerosis (SSc) is a connective tissue disease affecting women of childbearing age at least five times more than men. For a long time, pregnant women with SSc have high morbidity and mortality based on case reports and case series. Therefore, the disease was a contraindication for pregnancy. However, current retrospective studiesshow that despite of an increased frequency of prematurity and small for gestational age infants, overall maternal and neonatal survival is good. With close monitoring and appropriate therapy, most scleroderma patients can sustain a successful pregnancy.
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/89
10.37275/ijr.v4i1.89
Indonesian Journal of Rheumatology; Vol. 4 No. 1 (2013): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v4i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/89/87
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/90
2020-05-07T02:53:11Z
ijr:CAS
Erosive polyarthritis in multicentric reticulohistiocytosis mimics rheumatoid arthritis
Suryana, Bagus Putu Putra
Puspitasari, L
Wahono, Cesarius Singgih
Kalim, H
Multicentric reticulohistiocytosis (MRH) is a very rare multisystemic syndrome.1,2 The first case of MRH was described by Goltz and Layman in 1954 and so far only less than 200 cases have been reported.3-5 It is characterized by the insidious onset of polyarthritis that often evolves into a severe erosive deforming arthritis and characteristic skin lesions composed of nodules and plaques containing lipid-laden (periodic acidSchiff-positive) histiocytes and multinucleated giant cells.6 It most commonly affects the handsand cervical spine.7 MRH is also known as lipoid dermatoarthritis, lipoid rheumatism, and giant cell reticulohistiocytosis.4 MRH is occured due to infiltration of multinucleated giant cells and histiocytes into various tissues. The typical pictures include skin nodules and destructive polyarthritis.3 This entity is frequently mistaken for rheumatoid arthritis (RA).3 MRH is often associated with systemic complication and various types ofmalignancy. Therefore, sometimes it is considered a paraneoplastic syndrome
Indonesian Rheumatology Association
2018-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/90
10.37275/ijr.v4i1.90
Indonesian Journal of Rheumatology; Vol. 4 No. 1 (2013): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v4i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/90/88
Copyright (c) 2018 Indonesian Journal of Rheumatology
oai:ojs.data.journalrheumatology.or.id:article/91
2020-11-05T13:44:27Z
ijr:ORI
The Use of Tocilizumab in Combination with Methotrexate in Indonesian Rheumatoid Arthritis Patients (PICTURE INA Study)
Setyohadi, Bambang
Isbagio, Harry
Wachjudi, Rachmat Gunadi
Soeroso, Joewono
Kalim, Handono
Achadiono, Deddy Nur Wachid
Rheumatoid Arthritis
Tocilizumab
DMARD
DAS28
Background Aim of this research is to assess the efficacy and safety of tocilizumab (TCZ) in combination with methotrexate (MTX) in Indonesian patients with moderate to severe active rheumatoid arthritis (RA) who have an inadequate response to non-biologic DMARDs.Methods This was a interventional, prospective, single arm, multicenter, study in  Indonesian male or female patients aged ≥ 18 years old, with a diagnosis of RA for > 6 months based on ACR 1987 revised criteria with moderate to severe disease activity (DAS28 score > 3.2) after ≥ 12 weeks of non-biologic DMARDs treatment. The treatment consisted of tocilizumab, 8 mg/kg, intravenous (IV), every 4 weeks for a total of 6 infusion in combination with oral MTX (10−25 mg) every week. Efficacy was assessed based on the percentage of patients achieving low disease activity state (DAS28 < 3.2), percentage of patients achieving reduction > 1.2 point of DAS28, percentage of patients achieving remission (DAS28 < 2.6), and percentage of patients with ACR20, ACR50, and ACR70 responses. Descriptive statistics will be used for presentation of results.Results 100% patients reached low disease activity (DAS28 ≤ 3.2) at last study visit (week 24) and clinically significant improvement (reduction at least 1.2 units) at every visit in DAS28, both for ITT or PP patients. Remission (DAS28 < 2.6) was observed in 82.1% (ITT patients) and 93.1 % (PP patients) on last study visit. ACR20, ACR50, and ACR70 were achieved in 20%, 34%, and 34% (ITT patients), and 7%, 24%, and 62% (PP patients) on week 24. There were 3 out of 39 patients (7.69%) with adverse events (AE) and serious adverse events (SAE) that resulted in discontinuation of TCZ treatment, consisting of 1 patient with SAE of sepsis ec acquired community pneumonia, 1 patient with SAE of pneumonia tuberculosis, and 1 patient with AE of candidiasis. Most common adverse events were hepatic dysfunction (30.7%), hypercholesterolemia (23.1%), followed by arthralgia (20.5%) Twelve percent of patients needed dose modification due to elevated liver enzyme (elevated ALT/SGPT level).Conclusion Tocilizumab seems to be efficacious and likely to have good safety profile in non- biologic DMARD nonresponsive RA patients of PICTURE INA study.   Keywords: Rheumatoid Arthritis, Tocilizumab, DMARD, DAS28
Indonesian Rheumatology Association
2018-06-18
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/91
10.37275/ijr.v10i1.91
Indonesian Journal of Rheumatology; Vol. 10 No. 1 (2018): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v10i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/91/96
Copyright (c) 2018 Indonesian Journal of Rheumatology
https://creativecommons.org/licenses/by/4.0
oai:ojs.data.journalrheumatology.or.id:article/92
2020-11-05T13:46:02Z
ijr:ORI
Proportion and Factors that Associate with Incidence of Hepatotoxicity in Rheumatoid Arthritis Patients Treated with Methotrexate in RSCM Year 2013-2015
Prathitasari, Rahma Anindya
Isbagio, Harry
Background Rheumatoid arhtirtis (RA) is a chronic autoimmune disease that mainly attacks joints. It may causes joint deformities which leads to lower quality of life of RA patients. RA is treated with metothrexate (MTX) which inhibiting disease progression. MTX is known for its hepatotoxicity side effect, which is described by an elevation of aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) beyond the upper normal limit. Factors that may enhance hepatotoxicity are gender, age, cummulative dose of MTX, and duration therapy of MTX. Prevalence of hepatotoxicity caused by MTX therapy in RA patients in Indonesia is still unknown. The objective of this research is to know the proportion of hepatotoxicity and its associations with the factors that may enhance hepatotoxicity caused by MTX therapy in RA patients in RSCM.
Method Data about gender, age, cummulative dose and duration therapy of MTX are obtained from 115 RA patients' medical records.
Result Proportion of hepatotoxicity in RA patients treated with MTX in RSCM is 42.60%. Gender, age, cummulative dose and duration therapy of MTX do not significantly enhance hepatotoxicity (p>0.05).
Conclusion In conclusion gender, age, cummulative dose and duration therapy of MTX do not have association with hepatotoxicity in RA patients treated with MTX.
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Keywords: Rheumatoid Arthritis, Methotrexate, Hepatotoxicity
Indonesian Rheumatology Association
2018-06-18
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/92
10.37275/ijr.v10i1.92
Indonesian Journal of Rheumatology; Vol. 10 No. 1 (2018): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v10i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/92/90
Copyright (c) 2018 Indonesian Journal of Rheumatology
https://creativecommons.org/licenses/by/4.0
oai:ojs.data.journalrheumatology.or.id:article/93
2020-11-05T13:47:25Z
ijr:ORI
Clinical Manifestation and Laboratory Finding of Sclerosis Systemic Patient in Dr. Hasan Sadikin General Hospital Bandung : A Descriptive Quantitative Study
Budiman, Annisa Meivira
Dewi, Sumartini
Prananta, Marietta Shanti
Systemic sclerosis
clinical manifestation
laboratory finding
Background Systemic sclerosis is a chronic progressive multisystem autoimmune disease in connective tissue, characterized by its heterogeneous clinical manifestation. The purpose of this study is to give information regarding clinical manifestations and laboratory findings of systemic sclerosis patients to establish diagnosis of disease. Methods This study was conducted using descriptive quantitative design in September−October 2016. Data was collected from medical records of patients visiting Rheumatology Clinic Dr. Hasan Sadikin General Hospital from 1 July 2015−30 June 2016 using total sampling method. The collected data were expected to comprise patient’s clinical manifestation and laboratory finding. Results Most of patients had cutaneous 57 (100.0%) and musculoskeletal 40 (70.2%) involvement. Some of the disease manifestations were Raynaud’s phenomenon 38 (66.7%), fingertip lesion 33 (57.9%), stiffness in skin 34 (59.6%), and arthalgia 29 (50.9%). Gastrointestinal involvements were present in 29 (50.9%) patients. Renal involvement were determined from urinalysis result showed proteinuria 10 (17.5%) and hematuria 8 (14.0%), found in 24 (42.1%) patients, while pulmonary and cardiac involvements were found in 30 (52.6%) patients, acknowledged from clinical symptoms such as dyspnea 12 (21.1%). Identification of autoantibodies was found in 12 (21.1%) patients, with 10 (17.5%) patients had reactive ANA and 3 (3.5%) had positive anti-Scl70. Conclusion Most of systemic sclerosis patients had cutaneous involvement. Renal, pulmonary, and cardiac involvement were concluded based on laboratory findings. Keywords: Systemic sclerosis, clinical manifestation, laboratory finding
Indonesian Rheumatology Association
2018-06-18
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/93
10.37275/ijr.v10i1.93
Indonesian Journal of Rheumatology; Vol. 10 No. 1 (2018): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v10i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/93/91
Copyright (c) 2018 Indonesian Journal of Rheumatology
https://creativecommons.org/licenses/by/4.0
oai:ojs.data.journalrheumatology.or.id:article/94
2020-11-05T13:48:14Z
ijr:ORI
Correlation of sCD40L Level with Force Vital Capacity Value in Restrictive Lung Disease of Systemic Sclerosis Patients
Salim, Susanto
Wachjudi, Rachmat Gunadi
Dewi, Sumartini
sCD40L
Forced Vital Capacity
Restrictive Lung Disease
Systemic Sclerosis
Background: Interstitial Lung Disease (ILD) is one of the major cause of morbidity and mortality in Systemic Sclerosis (SSc). The gold standard to diagnose ILD is using High Resolution Computed Tomography (HRCT) scan. HRCT scan need a lot of cost and not always available, so another diagnosing test is needed as an alternative modality to diagnose ILD. ILD is a restrictive lung disease caused by lung fibrosis which is proved by the decrease of Forced Vital Capacity (FVC) in spirometry, and followed by the increase of soluble CD40L (sCD40L) level in plasma. This sCD40L may become a potential biomarker to evaluate lung fibrosis in SSc patients. The aim of this study is to analyze the correlation of sCD40L levels with FVC score in SSc patients with restrictive lung disease.Method:This cross sectional study was enrolled by the SSc patient who has restrictive lung disease based on spirometry test, at Rheumatology outpatient clinic dr. Hasan Sadikin Hospital from May 2015 to May 2016. All subject took underwent history, physical examination, spirometry and blood test for sCD40L. Data were analyzed using Pearson correlation.Result:There were 38 subjects involved in this study, dominated bywoman (92.1%) with mean age 41(±11) years. Subjects consist of 22(57,9%) with limited SSc, 16(42,1%) with diffuse SSc patients and 33 subjects treated with DMARD. Mean sCD40L serum in this study was 6.690,3(±2.377,3) pg/mL, with no statistical difference between limited and diffuse type (p=0.154). Mean FVC score in this study was 58.2(±10,8). There was no significant correlation between sCD40L serum with FVC (r=0.058; p=0.366). There was weak correlation on DMARD naïve subject between sCD40L serum and FVC (r=0.058; p=0.366) but statistically insignificant. There was no significant correlation between sCD40L serum with mRSS (r=0,066; p=0,346).Conclusion: This study founds no correlation between sCD40L with FVC in SSc at dr. Hasan Sadikin Hospital. Keyword : sCD40L, Forced Vital Capacity, Restrictive Lung Disease, Systemic Sclerosis
Indonesian Rheumatology Association
2018-06-18
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/94
10.37275/ijr.v10i1.94
Indonesian Journal of Rheumatology; Vol. 10 No. 1 (2018): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v10i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/94/92
Copyright (c) 2018 Indonesian Journal of Rheumatology
https://creativecommons.org/licenses/by/4.0
oai:ojs.data.journalrheumatology.or.id:article/95
2020-11-05T13:49:01Z
ijr:ORI
Validation of Modified COPCORD Questionnaire Indonesian Version as Screening Tool for Joint Pain and Musculoskeletal Diseases
Anshory, Muhammad
Wahono, Cesarius Singgih
Kalim, Handono
Al Rasyid, Harun
Validation
Questionnaire
COPCORD
Background: WHO-ILAR COPCORD Program is a program that aimed to obtain data on joints pain and musculoskeletal diseases in developing countries, one aspect which has not been studied is the ability of COPCORD questionnaire as a screening tool which standardized for  screening  joint pain and musculoskeletal diseases. Objective of this study is to assess the validity of modified COPCORD questionnaire Indonesian version in screening joint pain and musculoskeletal disease compared to examination by rheumatologists.Methods: The initial phase of the research is determining essential points, translation to Indonesian, and back translation. The second stage is testing questionnaires in communities which 100 respondents involved. Dependent variable is the diagnosis of rheumatic diseases and independent variables are pain in less and more than 7 days, high degree pain in less and more than 7 days, history of NSAIDs/Steroids/DMARDs use, and disabilities. Validation test was assessed by calculating the sensitivity, specificity, PPV, NPV, LR+, and ROC curve. Bivariate analysis using Chi Square analysis, and multivariate analysis using logistic regression.Results: The sensitivity test results is best obtained on the question history of NSAIDs/steroids/DMARDs use (100%) and specificity is best obtained on the question about disability (98%). ROC curve analysis which the results >85% obtained on the question of pain >7 days (90%), high degree pain >7 days (93%), and history of NSAIDs/steroids/DMARDs use (92%).  LR+ to diagnose rheumatic diseases found in all questions. Chi square analysis showed that all questions were significant with p <0.05 and odds ratio (OR) obtained most on high degree pain more than 7 days (OR: 180.167; 95% CI: 38.196-849.834).Conclusion: The modified COPCORD questionnaire Indonesian version has been adapted and can be a good tool in the screening of joint pain and musculoskeletal diseases compared to examination by rheumatologists. Keyword: Validation, Questionnaire, COPCORD
Indonesian Rheumatology Association
2018-06-18
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/95
10.37275/ijr.v10i1.95
Indonesian Journal of Rheumatology; Vol. 10 No. 1 (2018): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v10i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/95/93
Copyright (c) 2018 Indonesian Journal of Rheumatology
https://creativecommons.org/licenses/by/4.0
oai:ojs.data.journalrheumatology.or.id:article/96
2020-11-05T13:49:51Z
ijr:ORI
Prevalence of Albuminuria and Associated Factors among Gout Arthritis Patients in Cipto Mangunkusumo Hospital
Mahardhika, Jeffrey Christian
Anggoro, R.M. Suryo
Prevalence
Albuminuria
Gout Arthritis
Risk Factors
Background Gout arthritis associates with many comorbodities such as hyperuricemia, hypertension, hyperglycemia, obesity, and dyslipidemia, which are also factors for the development of/or predisposition factors of chronic kidney diseases (CKD). Albuminuria is a predictor factors for CKD. Screening for albuminuria is needed to be done in patients with high risk of CKD. This research was conducted to examine the prevalence of albuminuria and the associated factors in gout arthritis patients.Methods This research was a cross-sectional study from gout arthritis patients’ medical records in Cipto Mangunkusumo Hospital. We included all gout patients who treated within 2011−2015. Subjects with chronic kidney disease, in kidney replacement therapy, hypertension ≥ 10 years, and diabetes ≥ 5 years were excluded. Albuminuria was determined by urine dipstick result of protein ≥ 1+. Factors associated were age, sex, hyperuricemia, hypertension, stage of hypertension, hyperglycemia, obesity, dyslipidemia, uric acid level, and body mass index (BMI). Data associated with the factors were recorded and the associations were tested with chi square, fisher’s exact, or independent t-test.Results from 54 subjects included in this research, the prevalence of albuminuria was 20.4%. There were no significant associations between all factors and albuminuria tested by chi square and fisher’s exact test. Independent t-test’s results also showed no significant associations between all the factors and albuminuriaConclusion The prevalence of albuminuria in gout arthritis patient was 20.4%. There were no significant associatons between age, sex, hyperuricemia, hypertension, hyperglycemia, obesity, dyslipidemia, uric acid level, and body mass index (BMI) tested with albuminuria in gout arthritis patients in Cipto Mangunkusumo Hospital from 2011−2015.Keywords: Prevalence, Albuminuria, Gout Arthritis, Risk Factors
Indonesian Rheumatology Association
2018-06-18
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/96
10.37275/ijr.v10i1.96
Indonesian Journal of Rheumatology; Vol. 10 No. 1 (2018): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v10i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/96/94
Copyright (c) 2018 Indonesian Journal of Rheumatology
https://creativecommons.org/licenses/by/4.0
oai:ojs.data.journalrheumatology.or.id:article/97
2020-11-05T13:50:34Z
ijr:CAS
Management of Salmonella Septic Bursitis in Renal Transplant Recipient
Prasetya, Albert
Ariane, Anna
Setyohadi, Bambang
Immunocompromised state
septic bursitis
deep bursae
Salmonella
duration of therapy
Salmonella as a causative agent in septic bursitis is considered rare. We report a case of 56 years old male with history of renal transplantation and using mycophenolate mofetil, cyclosporine and methylprednisolone as maintenance, admitted due to 3-week-fever associated with tenderness and swelling on left shoulder. Upon investigation, a diagnosis of septic bursitis was established. Salmonella enteritidis as the definitive causative agent was revealed. He was treated with meropenem 1g IV three times daily and levofloxacin 500 mg IV once a day for 3 weeks, followed by oral ciprofloxacin 500 mg twice a day for 2 weeks and oral metronidazole 500 mg three times a day for 1 week with a total duration of 5 weeks of antibiotics. On the subsequent follow up there was no recurrence episode of fever and the swelling of the left shoulder subsided, no tenderness noted and the patient has no limitation of range of movement. Since immunocompromised state complicates the management, the duration of therapy may twice longer than the typical management of septic bursitis. Salmonella as etiologic agent should be considered as differential in immunocompromised patient with septic bursitis.Keywords: Immunocompromised state, septic bursitis, deep bursae, Salmonella, duration of therapy.
Indonesian Rheumatology Association
2018-06-18
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/97
10.37275/ijr.v10i1.97
Indonesian Journal of Rheumatology; Vol. 10 No. 1 (2018): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v10i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/97/95
Copyright (c) 2018 Indonesian Journal of Rheumatology
https://creativecommons.org/licenses/by/4.0
oai:ojs.data.journalrheumatology.or.id:article/98
2022-06-27T09:36:51Z
ijr:ORI
Correlation between Interleukin-6 and E-Selectin as a Marker of Endothelial Dysfunction in Rheumatoid Arthritis Patient without Traditional Cardiovascular Risk Factor
Boer, Jerry Eddya Putra
Hidayat, Rudy
Wijaya, Ika Prasetya
Rinaldi, Ikhwan
Rheumatoid arthritis (RA) is an autoimmune disease which has recently been recognized to manifest as not only intraarticular but also extraarticular symptoms. Cardiovascular events, presented either subclinically or clinically, were discovered more in AR patients. Atherogenic inflammatory mediator in AR including interleukin-6 (IL-6) was thought to be one of nontraditional cardiovascular risk factor contributing to increase the endothelial dysfunction biomarker such as E-Selectin. This study was purposed to determine the correlation between inflammatory mediator and endothelial dysfunction event, especially between IL-6 and E-Selectin, in RA patient without traditional cardiovascular risk factor. A cross-sectional study was performed to 40 RA patients of Rheumatology Clinic of Cipto Mangunkusumo National General Hospital, Indonesia from September to November 2017. Measurement of the level of IL-6 and E-Selectin were performed using enzyme-linked immunosorbent assay (ELISA). Bivariate correlation analysis was performed to determine the correlation between those two biomarkers. The mean age of this study subjects was 44.9 (13.1) years and median of disease duration was 36 months. This study showed weak correlation between IL-6 and E-Selectin level, but not statistically significant.232, p=0.149). There is weak correlation between IL-6 and sE-Selectin in rheumatoid arthritis patient without traditional risk factor cardiovascular
Keywords: traditional risk factor cardiovascular, E-Selectin, interleukin-6, pro inflammatory mediator, rheumatoid arthritis
Indonesian Rheumatology Association
2018-12-12
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/98
10.37275/ijr.v10i2.98
Indonesian Journal of Rheumatology; Vol. 10 No. 2 (2018): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v10i2
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/98/100
Copyright (c) 2018 Indonesian Journal of Rheumatology
https://creativecommons.org/licenses/by/4.0
oai:ojs.data.journalrheumatology.or.id:article/100
2022-06-27T09:28:04Z
ijr:ORI
Correlation Between Serum C-Reactive Protein (CRP) and Soluble Cd40 Ligand (sCD40L) with Disease Activity by Modified Rodnan Skin Score (mRSS) in Systemic Sclerosis Patients in Indonesia
Padmandani, Widi Palupi Ayu
Dewi, Sumartini
Hamijoyo, Laniyati
systemic sclerosis
fibrosis
CRP
sCD40L
and mRSS
Introduction: Systemic Sclerosis (SSc) is a chronic autoimmune disease which presents immunological, endothelial dysfunction, skin and organs fibrosis. The inflammatory process is an important pathophysiology of systemic sclerosis. Disease activity assessment using clinical parameters of Modified Rodnan Skin Score (mRSS) changes and inflammatory laboratory parameters of C-Reactive Protein (CRP), Erytrocyte Sedimentation Rate (ESR) and soluble CD40 ligand. The European Scleroderma Study Group (EscSG) Activity Index uses CRP. CRP is higher sensitivity and specificity than ESR (80% and 91.2%). The study aims to evaluate the correlation between CRP and sCD40L with disease activity by mRSS.Methods: This research was a cross-sectional study, and data of mRSS and sCD40L were obtained from the study, "Blind Clinical Trials Extract Ciplukan Herbs on Clinical Improvement of Skin Disorders, Inflammatory Process, Immunology and Fibrosis in Scleroderma Patientsâ€. CRP examination was done by using the rest samples of the study, conducted in December 2017. Data analysis with Rank-Spearman and Pearson Correlation..Result: There were fifty-eight subjects with mean age 38 ± 11 years old. Most of subjects were female (94.8%) and with a late disease duration > 2 years (74.1 %). Subjects consisted of 35 (60.3%) diffuse SSc and 23 (39.7 %) limited SSc. CRP was measured by Turbidimetric Immunoassay. Median (range) CRP serum was 2.89 (0.16–17.29) mg/L, while the median of sCD40L was 6457 (1018–17976) pg/mL, and the median of mRSS was 17 (4–36). There was no correlation between CRP and sCD40L with mRSS (r = -0.134, p = 0.167; and r = 0.023, p = 0.433).Conclusion: There was no correlation between CRP and sCD40L serum with mRSS in systemic sclerosis patients.
Indonesian Rheumatology Association
2018-12-12
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/100
10.37275/ijr.v10i2.100
Indonesian Journal of Rheumatology; Vol. 10 No. 2 (2018): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v10i2
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/100/99
Copyright (c) 2018 Indonesian Journal of Rheumatology
https://creativecommons.org/licenses/by/4.0
oai:ojs.data.journalrheumatology.or.id:article/101
2022-06-27T09:35:10Z
ijr:ORI
The Correlation Between Disease Activity Assessed by DAS28-ESR and Quality of Life Assessed by SF-36 in Rheumatoid Arthritis Patients
Vidyaniati, Putri
Wachjudi, Rachmat Gunadi
Tjandrawati, Anna
Hamijoyo, Laniyati
Background Rheumatoid arthritis is the most prevalent form of inflammatory arthritis. One of the key components for its multidimensional outcome is the disease activity, measured by DAS28-ESR. The physical, emotional, and social aspects of RA contribute to the quality of life, and SF-36 questionnaire can be used to measure it. This study aims to ascertain the correlation between the disease activity (DAS28-ESR) and the quality of life (SF-36) in RA patients.
Method This study was an analytical, descriptive study with a cross sectional design that took primary data from RA patients undergoing treatment in Rheumatology Clinic of Hasan Sadikin Hospital from February to April 2015. The patient’s data included sex, age, marital status, employment status, educational level, serostatus (RF and Anti-MCV), duration of diagnosis, total number of medications, total number of DMARD, DAS28-ESR scores, and SF-36 scores. The data was analysed with the Shapiro-Wilk normality test, followed by the Rank-Spearman correlation analysis.
Result There were 42 subjects, with an average age of 41 ± 12. The ratio between females and males was 20:1, and the majority of subjects (73,8%) had a positive serostatus (RF and/or anti-MCV). The score median of DAS28-ESR was 4,3, with the score median for SF-36 PCS being 39,8 and the score median for SF-36 MCS being 48,2. Based on the the Rank-Spearman analysis (CI of 95%), there was a correlation between DAS28-ESR score and SF-36 PCS score, with the correlation coefficient (r) of -0,577 (p < 0,001), and there was also a correlation between DAS28-ESR score and SF-36 MCS score with r of -0,368 (p = 0,008).
Conclusion There was a strong negative correlation between disease activity and physical component of quality of life, and a moderate negative correlation between disease activity and mental component of quality of life, and the two correlations were statistically significant.
Indonesian Rheumatology Association
2018-12-12
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/101
10.37275/ijr.v10i2.101
Indonesian Journal of Rheumatology; Vol. 10 No. 2 (2018): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v10i2
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/101/98
Copyright (c) 2018 Indonesian Journal of Rheumatology
https://creativecommons.org/licenses/by/4.0
oai:ojs.data.journalrheumatology.or.id:article/102
2022-06-27T09:39:51Z
ijr:CAS
Takayasu Arteritis : Diagnostic Approach
Chair, Malikul
Setyohadi, Bambang
Anggoro, RM Suryo
Ariane, Anna
Takayasu arteritis (TA) is a systemic, inflammatory large-vessel vasculitis of unknown etiology that most commonly affects women of childbearing age. It involves the aorta and its major branches. The main abnormalities found in this disease are vascular ischemic signs/symptoms including claudication, carotid bruit, weak distal pulsation. Hereby we report a case a 25-year-old unmarried female complained a recurrent left arm pain, worsening when she did her work as a doctor. Formerly, she had experienced intermittent bilateral leg pain for four years with strange sound coming from inside her neck. She was hospitalized half a year ago due to acute limb ischemic and she was diagnosed with TA after the imaging showed multiple stenosis in large arteries including bilateral neck area, shoulder area, abdominal aorta, and right renal artery. The inferior right extremity biopsy showed the histologist result of erythema nodosum appearance. Cuantitative C reactive protein (CRP): 19,8, erythrocyte sedimen rate (ESR): 53. The others laboratory data to exclude differential diagnosis are unremarkable. This report demonstrates the importance of diagnostic approach in rare case of Takayasu’s arteritis patients.
Keyword: Diagnostic; Vasculitis, Takayasu Arteritis
Indonesian Rheumatology Association
2018-12-12
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/102
10.37275/ijr.v10i2.102
Indonesian Journal of Rheumatology; Vol. 10 No. 2 (2018): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v10i2
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/102/103
Copyright (c) 2018 Indonesian Journal of Rheumatology
https://creativecommons.org/licenses/by/4.0
oai:ojs.data.journalrheumatology.or.id:article/103
2020-11-07T14:19:31Z
ijr:CAS
Recurrent Rheumatic Fever
Ismail, Patriotika
Sobur, Cecep Suryani
Olivia, Cyntia
Rheumatic fever (RF) may often be encountered in developing country including in Indonesia. RF is autoimmune disease resulted from Group-A Streptococcus upper respiratory tract infection. RF diagnostic criteria underwent some changes since it was first arranged. Patients with RF episode history have a higher risk to experience recurrence following Group-A Streptococcus pharyngeal infection and need long-term antibiotic prophylaxis to prevent severe disease and RHD. Here we present a case of patient who has RF and RHD history since the age of 10 years old. This case is reported to show recurrent RF management and prophylaxis treatment that can be done next to prevent recurrence of RF in the future.
Indonesian Rheumatology Association
2019-12-19
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/103
10.37275/ijr.v11i2.103
Indonesian Journal of Rheumatology; Vol. 11 No. 2 (2019): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v11i2
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/103/118
Copyright (c) 2019 Indonesian Journal of Rheumatology
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oai:ojs.data.journalrheumatology.or.id:article/110
2020-11-07T02:56:35Z
ijr:ORI
Mean Platelet Volume on Systemic Lupus Erythematosus Patients with and without Thrombocytopenia in Dr Hasan Sadikin Hospital Bandung: A Descriptive Study
Philo, Patrick
Hamijoyo, Laniyati
Turbawaty, Dewi Kartika
Abstract
Background : The aim of the study is to provide an insight about mean platelet volume (MPV) value in systemic lupus erythematosus (SLE) with and without thrombocytopenia patient. MPV wa expected to be used to determine the cause thrombocytopenia in lupus, so the patient could be treated appropriately.
Method : The study design was descriptive categoric, and the data were obtained by using cross-sectional method from patient’s medical record and lab examination result in the period from January 1st 2016 – January 31st 2018. The sampling method are done using total sampling. The inclusion criteria of this study were SLE patients which MPV and platelet count had been examined at the same time, the data used is data that was first discovered in the period of the study. The exclusion criteria were incomplete medical record data, patient with thrombocytosis, and SLE with comorbidity such as thrombotic disease (ischemic stroke and deep vein thrombosis), other high inflammatory overlap diseases (such as rheumatoid arthritis and inflammatory bowel disease), and infection.
Result : From 75 patients that match with the inclusion criteria, all patients were female and based on the age of diagnosis, most patients were in age group of 25-34 years old (41,33%). Based on the lab results, group with normal platelet count have 53 data of normal MPV and 12 data of high MPV, while group with thrombocytopenia have 6 data of normal MPV and 4 data of high MPV.
Conclusion : Group with normal MPV value and normal platelet count has the largest proportion, while the group with thrombocytopenia in lupus and high MPV value has the lowest proportion.
Indonesian Rheumatology Association
2019-06-12
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/110
10.37275/ijr.v11i1.110
Indonesian Journal of Rheumatology; Vol. 11 No. 1 (2019): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v11i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/110/109
Copyright (c) 2019 Indonesian Journal of Rheumatology
https://creativecommons.org/licenses/by/4.0
oai:ojs.data.journalrheumatology.or.id:article/111
2020-11-07T02:53:10Z
ijr:ORI
Correlation of Anxiety Disorder and Quality of Life in Systemic Lupus Erythematosus Patients
Emrizal, Kemala
Hamijoyo, Laniyati
Lidyana, Lynna
Background: Systemic Lupus Erythematosus (SLE), an autoimmune disease, can cause damage and impairment in the nervous system. Patients who had any manifestation of neurology can be classified as patients with Neuropsychiatric Systemic Lupus Erythematosus (NPSLE). One of the most frequent NPSLE manifestation is anxiety disorder. The presence of anxiety disorder is believed to be correlated with their ability to carry out daily activities. This study aims to see the correlation between anxiety disorder and quality of life (QOL) in patients with SLE.
Method: an analitic cross-sectional study was done. The data were collected by distributing validated questionnaires to patients diagnosed with SLE in the outpatient clinic of dr. Hasan Sadikin General Hospital. Quality of life and anxiety disorder was measured using Short From-36 (SF-36) and Zung Self-Rating Anxiety Scale (Zung-SAS), respectively. Normality test was done before correlating the variables using Pearson method.
Result: Forty-six SLE patients fitted with the inclusion criteria were participated in the study. The assessment using Zung-SAS showed that 9 (19.56%) correspondents had mild–moderate anxiety, and 1 (2.17%) had severe anxiety. The analysis of SF-36 showed the means of Physical Component Summary (PCS) and Mental Component Summary (MCS) which were 45.18 ± 8.23 and 47.11± 9.78, in order. The correlation test of Zung-SAS with PCS and MCS showed the result of r= -0.651 (p < 0,01) and -0.654 (p < 0,01), respectively.
Conclusion: There is a significant negative correlation between anxiety disorder and QOL in patients with SLE. The result of this study showed that the high degree of ones anxiety was in a parallel line with their low level of QOL, so it is important to do an early detection and prevention of anxiety disorder in SLE patients.
Keywords: Anxiety disorder, quality of life, Systemic Lupus Erythematosus, Zung Self Rating Anxiety Scale.
Indonesian Rheumatology Association
2019-06-12
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/111
10.37275/ijr.v11i1.111
Indonesian Journal of Rheumatology; Vol. 11 No. 1 (2019): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v11i1
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/111/106
Copyright (c) 2019 Indonesian Journal of Rheumatology
https://creativecommons.org/licenses/by/4.0
oai:ojs.data.journalrheumatology.or.id:article/112
2020-11-07T14:13:42Z
ijr:REV
Randomized Controlled Trial of Herbal Extracts (Eugenia polyantha, Apium graveolens, Nigella sativa) and Allopurinol Effect on Serum Uric Acid, Urinary Uric Acid and High Sensitivity C-Reactive Protein Levels in Subject with Hyperuricemia
Sutoko, Bantar
Hellmi, Rakhma Yanti
W, Ika Vemillia
L, Stepanus Agung
Background: Eugenia polyantha, Apium graveolens, and Nigella sativa are extracts which in preclinical trial can reduce uric acid serum, increase urinary uric acid excretion. Allopurinol is an inhibitor of the xanthine oxidase enzyme which can also reduce the increase of hsCRP in subjetcs with hyperuricemia.
Objective: To determine the safety and effect of herbal extracts in reducing serum uric acid, increasing uric acid excretion and reducing hsCRP levels in patients with hyperuricemia compared with allopurinol.
Method: This study was a double blind randomized controlled trial (RCT). The subjects were hyperuricemic patients aged ³18 years. The subject was divided into groups that received 3000 mg/day of herbal extracts and allopurinol 100 mg/day for 4 weeks. Evaluation of serum uric acid and urinary uric acid urine were every week, and hsCRP levels was baseline and end of intervention. Other parameters related to the safety of use were examined every 2 weeks.
Results: A number of 44 hyperucemia subjects, 23 subjects received herbal extracts and 21 subjects received allopurinol. The decrease of uric acid serum levels in the herbal extract group was 0,467±1,123;0,600;-2,70-3,00 (p=0.027), while in the allopurinol group 1,11
4±0,813;1,30;-1,30-2,30 (p=0,000). Uric acid excretion in the herbal extract group decrease 71,00±1,970;5,50;-92,00-702,00 (p=0,269) and in the allopurinol group decrease 64,54±1,298;22,00;-29,00-440,0 (p=0.003). The reduction of hsCRP in the herbal extract group was 0.08±0.639; 0.01; -1.55-2.05 (p=0.658), and the allopurinol group was -0.33 ± 0.806; -0.01; -2.73- 0.31 (p=0.256).
Conclusion: Herbal extracts (Eugenia poliantha, Apium graveolens and Nigella sativa) and allopurinol can reduce serum uric acid levels in patients with hyperuricemia. Allopurinol also can reduce urinary uric acid excretion.
Indonesian Rheumatology Association
2019-12-19
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://journalrheumatology.or.id/index.php/ijr/article/view/112
10.37275/ijr.v11i2.112
Indonesian Journal of Rheumatology; Vol. 11 No. 2 (2019): Indonesian Journal of Rheumatology
2581-1142
2086-1435
10.37275/ijr.v11i2
eng
https://journalrheumatology.or.id/index.php/ijr/article/view/112/112
Copyright (c) 2019 Indonesian Journal of Rheumatology
https://creativecommons.org/licenses/by/4.0
b04cbb083dcd5b5ea6c60e727902da54