Article Sidebar

Download
PDF
Statistic
Read Counter : 655 Download : 473

Main Article Content

Abstract

Background. Osteophyte is a reparative response to cartilage breakdown in osteoarthritis (OA) and osteophyte formation is a knee stabilizing factor. Disability could be found in patients with knee OA. 

Objective. To identify the profile of osteophyte formation (location, size, and direction) based on knee radiograph and functional status examination in knee OA patients who presented to the Rheumatology Clinic, Cipto Mangunkusumo Central National General Hospital.

Methods. Samples were taken by consecutive approach. Knee radiographs (weight bearing anteroposterior and30 degrees flexion skyline views) and functional status examinations were performed on 100 patients with knee OA (90 females and 10 males with ages ranging from 51 to 74 years old). A radiologist assessed films for osteophyte profile such as location, size, and direction according to standard atlas. One knee with the severe radiological assessment based on OA grade was selected from one patient to be the profile. Lequesne
Algofunctional Index was also taken from the patients. 

Results. The site of osteophyte in patients with knee OA was mostly found at lateral femur (85/100 subjects). Based on specific location, grade 2 osteophyte at lateral femur was the most frequent size (49/100 subjects) and osteophyte extending toward the lower middle at
lateral patella (65/100 subjects) was the most frequent direction of osteophyte. The most frequent profile for size and direction of osteophyte at specific location was the grade 2 osteophyte extending toward the lower middle at lateral patella (35/100 subjects). Severe functional status impairment was found in 53% of the patients. The most frequent functional status found according to specific location of osteophyte was severe functional
status impairment in patients with oste ophyte at lateral femur (46/100 subjects). The most frequent functional status of OA patients based on the size and direction of osteophyte at specific location was the severe functional impairment in the patients with grade 2  osteophyte at lateral femur (27/100 subjects) and the patients with osteophyte extending towards the lower middle at lateral patella (37/100 subjects) respectively.

Conclusions. Osteophyte at lateral femur, osteophyte at lateral tibiofemoral compartment, grade 2 osteophyte at lateral femur, and osteophyte extending toward the lower middle at lateral patella were the profiles of osteophyte which mostly showed severe functional status impairment in patients with knee OA.

Article Details

How to Cite
Mesanti, O., SETIYOHADI, B., Kasjmir, Y. I., Budihusodo, U., & Oemardi, M. (2018). Profile of osteophyte location in different grades of functional status in patients with knee osteoarthritis. Indonesian Journal of Rheumatology, 1(2). https://doi.org/10.37275/ijr.v2i1.23

References

  1. Kasjmir YI. The pathogenesis of osteoarthritis: a degenerative or
  2. inflammatory process? Presented at the Lunch Clinic of Rheumatology,
  3. Department of Internal Medicine. Jakarta, 2003.
  4. Boegard T, Rudling O, Petersson IF, Jonsson K. Correlation between
  5. radiographically diagnosed osteophytes and magnetic resonance
  6. detected cartilage defects in the patellofemoral joint. Ann Rheum Dis
  7. ;57:395-400.
  8. Lanyon P, O’Reilly S, Jones A, Doherty M. Radiographic assessment
  9. of symptomatic knee osteoarthritis in the community: definitions and
  10. normal joint space. Ann Rheum Dis 1998;57(10):595-601.
  11. Nagaosa Y, Langon P, Doherty M. Characterisation of size and
  12. direction of osteophyte in knee osteoarthritis: a radiographic study.
  13. Ann Rheum Dis 2002;61:319-24.
  14. Neame RL, Carr AJ, Muir K, Doherty M. UK community prevalence
  15. of knee chondrocalcinosis evidence that correlation with osteoarthritis
  16. is through a shared association with osteophyte. Ann Rheum Dis
  17. ;62(6):513-8.
  18. Wollheim FA. Early stages of osteoarthritis: the search for sensitive
  19. predictors. Ann Rheum Dis 2003;62(11):1031-2.
  20. Brandt KD. Chondrocalcinosis, osteophytes and osteoarthritis. Ann
  21. Rheum Dis 2003;62:499-500.
  22. Warashina H, Hasegawa Y, Tsuchiya H, Kitamura S, Yamauchi KI,
  23. Torii Y et al. Clinical, radiographic, and thermographic assessment of
  24. osteoarthritis in the knee joints. Ann Rheum Dis 2002;61:852-4.
  25. Tulaar ABM. The rehabilitation aspect of knee pain. [Aspek rehabilitasi
  26. nyeri lutut] In: Setiyohadi B, Kasjmir YI, Mahfudzoh S, editors.
  27. Complete papers of the 2000 rheumatology scientific meeting. [Naskah
  28. lengkap temu ilmiah reumatologi 2000] Proceedings of the 2000
  29. Rheumatology Scientific Meeting; 2000 Oct 6-8, Jakarta, Indonesia.
  30. Jakarta: Indonesian Rheumatism Association; 2000. p. 98-104.
  31. Chandnani V, Resnick D. Roentgenologic diagnosis. In: Moskowitz
  32. RW, Howel DS, Altman RD, Buckwalter JA, Goldberg VM, editors.
  33. Osteoarthritis diagnosis and medical/surgical management. 3rd ed.
  34. Philadelphia: WB Saunders; 2001. p. 239-67.
  35. Dieppe P, Cooper C, Campion G, Watt I, Kuettner KE, Bullough PG et
  36. al. Osteoarthritis. In: Klippel JH, Dieppe PA, editors. Rheumatology.
  37. London: Mosby; 1994. p. 7/2.1-3.8.
  38. Graff RD, Lazarowski ER, Banes AJ, Lee GM. ATP release by
  39. mechanically loaded porcine chondrons in pellet culture. Arthritis
  40. Rheum 2000;43(7):1571-9.
  41. Rosen F, McCabe G, Quach J, Solan J, Terkeltaub R, Seegmiller JE,
  42. et al. Differential effects of aging on human chondrocytes responses to
  43. transforming growth factor beta: increased pyrophosphate production
  44. and decreased cell proliferation. Arthritis Rheum 1997;40(7):1275-81.
  45. Broto HR. Joint cartilage in osteoarthritis. [Rawan sendi pada
  46. osteoarthritis] In: Setiyohadi B, Kasjmir YI, Mahfudzoh S, editors.
  47. Complete papers of the 2000 rheumatology scientific meeting. [Naskah
  48. lengkap temu ilmiah reumatologi 2000] Proceedings of the 2000
  49. Rheumatology Scientific Meeting; 2000 Oct 6-8, Jakarta, Indonesia.
  50. Jakarta: Indonesian Rheumatism Association; 2000. p. 22-6.
  51. Boegard T, Rudling O, Petersson IF, Jonsson K. Correlation between
  52. radiographically diagnosed osteophytes and magnetic resonance
  53. detected cartilage defects in the tibiofemoral joint. Ann Rheum Dis
  54. ;57(7):401-7.
  55. Cicuttini FM, Wluka AE, Stuckey SL. Tibial and femoral cartilage
  56. changes in knee osteoarthritis. Ann Rheum Dis 2001;60:977-80.
  57. van Osch GJVM, van der Kraan PM, van Valburg AA, van den
  58. Berg WB. The relation between cartilage damage and osteophyte
  59. size in a murine model for osteoarthritis in the knee. Rheumatol Int
  60. ;16(3):115-9.
  61. McCauley TR, Kornaat PR, Jee WH. Central osteophytes in the knee:
  62. prevalence and association with cartilage defects on MR imaging. AJR
  63. ;176:359-64.
  64. Kobayashi T. Osteophyte formation in the knee joint: a radiological
  65. study. Nippon Seikeigeka Gakkai Zasshi 1994;68(4):139-50.
  66. Miyazaki T, Wada M, Kawahara H, Sato M, Baba H, Shimada
  67. S. Dynamic load at baseline can predict radiographic disease
  68. progression in medial compartment knee osteoarthritis. Ann Rheum
  69. Dis 2001;61:617-22.
  70. Slemenda C, Brandt KD, Heilman DK, Mazzuca S, Braunstein EM,
  71. Katz BP, et al. Quadriceps weakness and osteoarthritis of the knee.
  72. Ann Intern Med 1997;127(2):97-104.
  73. Hurley MV, Scott DL, Rees J, Newham DJ. Sensorimotor changes
  74. and functional performance in patients with knee osteoarthritis. Ann
  75. Rheum Dis 1997;56:641-8.
  76. O’Reilly SC, Jones A, Muir KR, Doherty M. Quadriceps weakness in
  77. knee osteoarthritis: the effect on pain and disability. Ann Rheum Dis
  78. ;57:588-94.
  79. Sharma L, Dunlop DD, Cahue S, Song J, Hayes KW. Quadriceps
  80. strength and osteoarthritis progression in malaligned and lax knees.
  81. Ann Intern Med 2003;138:613-9.
  82. Messier SP, Loeser RF, Miller GD, Morgan TM, Rejeski WJ, Sevick
  83. MA, et al. Exercise and dietary weight loss in overweight and obese
  84. older adults with knee osteoarthritis: the arthritis, diet, and activity
  85. promotion trial. Arthritis Rheum 2004;50(5):1501-10.
  86. Kertia N, Savitri KE, Rahardjo P, Asdie AH. The association between
  87. inflammation and clinical degree of osteoarthritis. [Hubungan inflamasi
  88. dengan gradasi klinik osteoarthritis] In: Setiyohadi B, Kasjmir YI, editors. Complete papers of the 2003 rheumatology scientific meeting.
  89. [Naskah lengkap temu ilmiah reumatologi 2003] Proceedings of the
  90. Rheumatology Scientific Meeting; 2003 Sept 19-21, Jakarta, Indonesia. Jakarta: Indonesian Rheumatism Association; 2003. p. 32-9.
  91. McAlindon TE, Snow S, Cooper C, Dieppe PA. Radiographic patterns
  92. of osteoarthritis of the knee joint in the community: the importance of
  93. the patellofemoral joint. Ann Rheum Dis 1992;51:844-9.
  94. Pottenger LA, Phillips FM, Draganich FL. The effect of marginal
  95. osteophytes on reduction of varus-valgus instability in osteoarthritis
  96. knees. Arthritis Rheum 1990;33(6):853-8.