Effect of Vitamin D Supplementation on Regulatory T Cells of Systemic LupusErythematosus: A Systematic Review

Abstract

Background. Systemic lupus erythematosus (SLE) is associated with a
global reduction in regulatory T cells (Tregs). Vitamin D supplementation
that is efficacious, safe, and reasonably priced has the potential to reduce
morbidity in SLE. This study was aimed to systematically assess the efficacy
of vitamin D supplementation in enhancing Tregs concentration or Tregsrelated

marker. Methods. A systematic review of the literature for clinical
studies was performed on Pubmed, Proquest, and Google Scholar. Studies
were assessed for risk of bias using Newcastle Ottawa Scale. All clinical
studies that investigated the effects of vitamin D supplementation on Tregs
in SLE patients were included. Key evidence was analyzed and qualitatively
synthesized. Results. Three relevant studies were included. All studies were
of high-quality. Vitamin D supplementation consistently increased Tregs
concentration across all included studies. Conclusion. The current study
supports the evidence that vitamin D supplementation enhanced Tregs
concentration in SLE patients.