Patients with Sjogren's Syndrome and Depression Who Got MenometrorraghiaAfter Receiving Antidepressant

Abstract

Background: Sjogren's Syndrome (SS) is a systemic autoimmune disease
that attacks the mucous glands and other organs of the body. SS can also
manifest in neuropsychiatric forms such as fatigue, depression, and
anxiety. Case presentation: Whether the menometrorrhagia that occurs in
SS patients who has depression is caused by the disease or caused by the
administration of antidepressant and which antidepressant is appropriate
for patient. The method is by searching for scientific evidence through
trusted databases, such as PubMEd, Cochrane, Scholar, Springer and
Medscape using The Boolean Operator method using keywords with filters
for journal publications in the last 15 years, human research subjects and
English language. There were 6 studies that matched the clinical question.
Conclusion: There is an evidence that meno/metrorrhagia in SS patients
can be caused by the disease itself and the antidepressant that were taking.
It preferable to be substituted the antidepressants with less bleeding
incidence such as Clomipramine, Fluvoxamine, and Mirtazapine.