Quantitative Evaluation of Proteinuria with Urinalysis Test and Comparing ItsCorrelation with Random Spot Urine PCR and 24-Hour Urine Protein in SLEPatients

Abstrak

Introduction: Lupus nephritis is an important concern among systemic
lupus erythematosus (SLE) patients in Asia, and its mortality rate was
reported to be 6 times higher compared to the general population. 24-hour
urine protein collection has long been used as the gold standard test to
assess proteinuria. This study aimed to assess the correlation of urinalysis
test with random spot urine protein-creatinine ratio (PCR) compared with
24- hour urine protein. Methods: This was a retrospective study. The
electronic medical records of all SLE patients seen in the rheumatology clinic of Hospital Sultan Ismail from 1st January 2017 to 1st January 2021 were reviewed. Patients who had urinalysis, urine protein-creatinine ratio, and24-hour urine protein tests were identified. Data on demography, urinalysis, random spot urine protein-creatinine ratio, and 24-hour urine protein were obtained and analysed. Results: The correlation between urinalysis and 24hour

urine protein was strong (r=0.702), whereas the correlation between
urinalysis and urine PCR was stronger (r=0.797). Our study also showed the
correlation between random urine protein-creatinine ratio and 24-hour urine
protein is strong (r=0.782). Conclusion: Urinalysis correlates well with both
random spot urine protein-creatinine ratio and 24-hour urine protein, and
the correlation is stronger with urine protein-creatinine ratio.