The The Role of 25-Hydroxy Vitamin D and Cartilage Oligomeric Matrix Protein(COMP) Serum in Knee Osteoarthritis

Abstrak

Background. Osteoarthritis (OA) is a prevalent disease of the
musculoskeletal system that affects over 528 million individuals worldwide,
with 73% of those diagnosed being aged 55 or older. The knee joint is most
commonly affected, along with the hip and hand joints. Vitamin D is
essential for maintaining bone and cartilage metabolism. In chondrocytes,
the presence of the vitamin D receptor (VDR) regulates the expression of
metalloproteinase. The purpose of this investigation is to examine the
correlation between vitamin D (25(OH)D) and cartilage oligomeric matrix
protein (COMP) serum in knee osteoarthritis. Methods. The cross-sectional
study was conducted by the Rheumatology Division at RSMH Palembang.
Patients diagnosed with knee osteoarthritis based on the 1990 ACR criteria
were included.  The chemoluminescent immunoassay and the Human
Cartilage Oligometric Matrix Protein ELISA Reagent were used to measure
the levels of vitamin D (25(OH)D) and COMP serum. Results. Thirty
participants took part in this study from July to December 2022. According
to this study, 33% had insufficiency and 67% had a deficiency of vitamin D.
Spearman's Rho test shows that there is a strong negative correlation
between vitamin D (25(OH)D) and COMP serum. Conclusion. Vitamin D
(25(OH)D) and COMP serum levels were significantly correlated in knee
osteoathritis.